benzphetamine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
329 156-08-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzphetamine
  • (+)-Benzphetamine
  • (S)-Benzphetamine
  • benzphetamine hydrochloride
  • benzphetamine HCl
A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
  • Molecular weight: 239.36
  • Formula: C17H21N
  • CLOGP: 4.38
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -4.01
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 10.44 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 0 Hosey CM, Chan R, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Oct. 26, 1960 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA PE N0000175372 Appetite Suppression
FDA EPC N0000175423 Sympathomimetic Amine Anorectic
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:35640 adrenergic uptake inhibitors
CHEBI has role CHEBI:51039 dopamine reuptake inhibitor
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D002491 Central Nervous System Agents
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D015259 Dopamine Agents
MeSH PA D018765 Dopamine Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics
FDA PE N0000175651 Increased Sympathetic Activity

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Obesity indication 414916001 DOID:9970
Heart valve disorder contraindication 368009 DOID:4079
Bipolar disorder contraindication 13746004 DOID:3312
Glaucoma contraindication 23986001 DOID:1686
Feeling agitated contraindication 24199005
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Substance abuse contraindication 66214007
Psychotic disorder contraindication 69322001
Pulmonary hypertension contraindication 70995007 DOID:6432
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Angina pectoris contraindication 194828000
Mania contraindication 231494001
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.71 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter RELEASING AGENT CHEMBL CHEMBL
Synaptic vesicular amine transporter Transporter INHIBITOR CHEMBL CHEMBL
Alpha-2A adrenergic receptor GPCR WOMBAT-PK
Alpha-1A adrenergic receptor GPCR WOMBAT-PK

External reference:

IDSource
4019628 VUID
N0000147721 NUI
5411-22-3 SECONDARY_CAS_RN
1422 RXNORM
C0005096 UMLSCUI
CHEBI:3044 CHEBI
CHEMBL3545985 ChEMBL_ID
DB00865 DRUGBANK_ID
CHEMBL3544906 ChEMBL_ID
D001589 MESH_DESCRIPTOR_UI
5311017 PUBCHEM_CID
978 INN_ID
0M3S43XK27 UNII
109114 MMSL
4262 MMSL
d00807 MMSL
386111003 SNOMEDCT_US
6088007 SNOMEDCT_US
67428007 SNOMEDCT_US
4018067 VANDF
4019628 VANDF
001800 NDDF
004725 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 10702-040 TABLET 50 mg ORAL ANDA 20 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 10702-040 TABLET 50 mg ORAL ANDA 20 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 12634-118 TABLET 50 mg ORAL ANDA 21 sections
benzphetamine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17224-672 TABLET 50 mg ORAL ANDA 20 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 33261-458 TABLET 50 mg ORAL ANDA 20 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42806-081 TABLET, FILM COATED 50 mg ORAL ANDA 21 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 43063-541 TABLET 50 mg ORAL ANDA 20 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 43063-541 TABLET 50 mg ORAL ANDA 20 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 43063-541 TABLET 50 mg ORAL ANDA 20 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 43063-541 TABLET 50 mg ORAL ANDA 20 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 50090-1024 TABLET 50 mg ORAL ANDA 20 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 50090-1024 TABLET 50 mg ORAL ANDA 20 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-5837 TABLET, FILM COATED 50 mg ORAL ANDA 21 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-5837 TABLET, FILM COATED 50 mg ORAL ANDA 21 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 53217-175 TABLET 50 mg ORAL ANDA 21 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 71335-0451 TABLET 50 mg ORAL ANDA 20 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 71335-0451 TABLET 50 mg ORAL ANDA 20 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 75834-100 TABLET 25 mg ORAL ANDA 22 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 75834-102 TABLET 50 mg ORAL ANDA 22 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 76519-1154 TABLET 50 mg ORAL ANDA 11 sections