benzphetamine indications/contra

Stem definitionDrug idCAS RN
329 156-08-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzphetamine
  • (+)-Benzphetamine
  • (S)-Benzphetamine
  • benzphetamine hydrochloride
  • benzphetamine HCl
A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
  • Molecular weight: 239.36
  • Formula: C17H21N
  • CLOGP: 4.38
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -4.01
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 26, 1960 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
CHEBI has role CHEBI:35524 sympathomimetic agent
CHEBI has role CHEBI:51039 dopamine uptake inhibitor
CHEBI has role CHEBI:50507 appetite depressant
CHEBI has role CHEBI:35640 adrenergic uptake inhibitor
MeSH PA D001337 Autonomic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D015259 Dopamine Agents
MeSH PA D018765 Dopamine Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics
FDA PE N0000175372 Appetite Suppression
FDA PE N0000175651 Increased Sympathetic Activity
FDA EPC N0000175423 Sympathomimetic Amine Anorectic

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Obesity indication 414916001 DOID:9970
Heart valve disorder contraindication 368009 DOID:4079
Bipolar disorder contraindication 13746004 DOID:3312
Glaucoma contraindication 23986001 DOID:1686
Feeling agitated contraindication 24199005
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Substance abuse contraindication 66214007
Psychotic disorder contraindication 69322001
Pulmonary hypertension contraindication 70995007 DOID:6432
Arteriosclerotic vascular disease contraindication 72092001 DOID:2349
Diabetes mellitus contraindication 73211009 DOID:9351
Angina pectoris contraindication 194828000
Mania contraindication 231494001
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.71 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter RELEASING AGENT CHEMBL CHEMBL
Synaptic vesicular amine transporter Transporter INHIBITOR CHEMBL CHEMBL
Alpha-1A adrenergic receptor GPCR WOMBAT-PK
Alpha-2A adrenergic receptor GPCR WOMBAT-PK

External reference:

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IDSource
4019628 VUID
N0000147721 NUI
C0005096 UMLSCUI
0M3S43XK27 UNII
978 INN_ID
5411-22-3 SECONDARY_CAS_RN
DB00865 DRUGBANK_ID
5311017 PUBCHEM_CID
4019628 VANDF
N0000147721 NDFRT
N0000005977 NDFRT
1422 RXNORM
386111003 SNOMEDCT_US
67428007 SNOMEDCT_US
d00807 MMSL
004725 NDDF
CHEBI:3044 CHEBI
CHEMBL1201358 ChEMBL_ID
CHEMBL3544906 ChEMBL_ID
CHEMBL3545985 ChEMBL_ID
D001589 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 10702-040 TABLET 50 mg ORAL ANDA 12 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 12634-118 TABLET 50 mg ORAL ANDA 12 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 23155-174 TABLET, FILM COATED 50 mg ORAL ANDA 12 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 33261-458 TABLET 50 mg ORAL ANDA 13 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42806-081 TABLET, FILM COATED 50 mg ORAL ANDA 12 sections
benzphetamine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-425 TABLET 50 mg ORAL ANDA 12 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 43063-541 TABLET 50 mg ORAL ANDA 12 sections
benzphetamine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43547-263 TABLET 50 mg ORAL ANDA 13 sections
benzphetamine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 46672-844 TABLET 50 mg ORAL ANDA 13 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 50090-1024 TABLET 50 mg ORAL ANDA 12 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 53217-175 TABLET 50 mg ORAL ANDA 12 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 55289-158 TABLET 50 mg ORAL ANDA 12 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 63629-4139 TABLET 50 mg ORAL ANDA 11 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 64376-650 TABLET 50 mg ORAL ANDA 12 sections
Regimex HUMAN PRESCRIPTION DRUG LABEL 1 66992-399 TABLET 25 mg ORAL ANDA 13 sections
Benzphetamine HUMAN PRESCRIPTION DRUG LABEL 1 67433-512 TABLET 25 mg ORAL ANDA 12 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 71335-0451 TABLET 50 mg ORAL ANDA 12 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 71335-0507 TABLET, FILM COATED 50 mg ORAL ANDA 12 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 75834-100 TABLET 25 mg ORAL ANDA 13 sections
Benzphetamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 75834-102 TABLET 50 mg ORAL ANDA 13 sections
BENZPHETAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 76519-1154 TABLET 50 mg ORAL ANDA 12 sections