homosalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
analgesic anti-inflammatory 3279 118-56-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • homosalate
  • homomenthyl salicylate
  • kemester
cpd not photoallergenic
  • Molecular weight: 262.35
  • Formula: C16H22O3
  • CLOGP: 5.92
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -3.85
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 733.46 15.23 224 8124 24152 63456522
Chronic sinusitis 226.84 15.23 79 8269 12764 63467910
Paraesthesia oral 199.14 15.23 80 8268 19176 63461498
Procedural pain 187.02 15.23 79 8269 21490 63459184
Drug ineffective 114.61 15.23 347 8001 1044418 62436256
Body tinea 114.18 15.23 30 8318 1855 63478819
Vaginal flatulence 110.50 15.23 33 8315 3260 63477414
Inhibitory drug interaction 101.92 15.23 30 8318 2819 63477855
Proctitis 98.06 15.23 34 8314 5407 63475267
Radiculopathy 96.72 15.23 38 8310 8573 63472101
Infection susceptibility increased 95.65 15.23 30 8318 3491 63477183
Therapeutic product effect incomplete 95.58 15.23 99 8249 124957 63355717
Female genital tract fistula 94.29 15.23 36 8312 7523 63473151
Dyspepsia 80.03 15.23 82 8266 102114 63378560
Vaginal discharge 77.38 15.23 33 8315 9165 63471509
Glucose tolerance impaired 77.31 15.23 30 8318 6547 63474127
Poor quality sleep 77.22 15.23 42 8306 19893 63460781
Purpura 67.55 15.23 32 8316 11353 63469321
Impaired quality of life 61.74 15.23 32 8316 13751 63466923
Bone density decreased 57.18 15.23 31 8317 14581 63466093
Colitis ulcerative 54.49 15.23 37 8311 26054 63454620
Hyperlipidaemia 53.82 15.23 33 8315 19538 63461136
Impaired work ability 52.01 15.23 31 8317 17444 63463230
Oral candidiasis 51.63 15.23 34 8314 22764 63457910
Frequent bowel movements 48.92 15.23 33 8315 22989 63457685
Skin disorder 45.92 15.23 35 8313 29472 63451202
Local anaesthetic systemic toxicity 43.57 15.23 12 8336 887 63479787
Oral herpes 42.95 15.23 32 8316 26042 63454632
Removal of foreign body 42.09 15.23 7 8341 41 63480633
Pyrexia 41.66 15.23 146 8202 470332 63010342
Tracheal deviation 39.45 15.23 8 8340 154 63480520
Weight decreased 38.74 15.23 101 8247 276697 63203977
Colitis 38.05 15.23 39 8309 48489 63432185
Phrenic nerve paralysis 37.93 15.23 8 8340 188 63480486
Rectal haemorrhage 35.92 15.23 38 8310 48992 63431682
Herpes zoster 32.85 15.23 47 8301 82415 63398259
Haematochezia 31.49 15.23 37 8311 53507 63427167
Cellulitis 27.34 15.23 43 8305 81915 63398759
Infusion related reaction 26.87 15.23 82 8266 245439 63235235
Foreign body in respiratory tract 23.84 15.23 6 8342 312 63480362
Anaphylactic shock 22.25 15.23 21 8327 23612 63457062
Cataract 21.96 15.23 32 8316 57021 63423653
Constipation 21.74 15.23 72 8276 224871 63255803
Rheumatoid arthritis 20.94 15.23 4 8344 253815 63226859
Nausea 20.45 15.23 186 8162 854285 62626389
Alopecia 19.55 15.23 10 8338 337526 63143148
Purtscher retinopathy 18.97 15.23 4 8344 94 63480580
Anaemia 18.52 15.23 82 8266 293348 63187326
Jarisch-Herxheimer reaction 18.12 15.23 5 8343 372 63480302
Drug intolerance 18.09 15.23 9 8339 308652 63172022
Systemic lupus erythematosus 17.86 15.23 3 8345 208915 63271759
Chemical burn 17.53 15.23 5 8343 420 63480254
Foetal exposure during delivery 16.92 15.23 4 8344 160 63480514
Dermatophytosis 16.29 15.23 4 8344 188 63480486
Language disorder 15.72 15.23 7 8341 2153 63478521
Live birth 15.54 15.23 18 8330 25612 63455062

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anal inflammation 75.73 18.85 20 4513 1280 34951118
SARS-CoV-2 test negative 65.72 18.85 17 4516 1003 34951395
Proctalgia 53.36 18.85 22 4511 5701 34946697
Accident 49.09 18.85 20 4513 5027 34947371
Appendicolith 44.77 18.85 22 4511 8579 34943819
Ventricular fibrillation 42.37 18.85 30 4503 22924 34929474
Cardiogenic shock 40.59 18.85 31 4502 26587 34925811
Appendicitis 38.59 18.85 24 4509 14783 34937615
Removal of foreign body 35.76 18.85 6 4527 38 34952360
Haemorrhoids 33.93 18.85 22 4511 14553 34937845
Cardiac arrest 30.68 18.85 49 4484 96110 34856288
Body temperature increased 28.18 18.85 21 4512 17347 34935051
Ascites 25.82 18.85 31 4502 46540 34905858
Stress 23.37 18.85 24 4509 30323 34922075
Constipation 22.84 18.85 53 4480 136929 34815469
Methaemoglobinaemia 21.17 18.85 10 4523 3571 34948827
Abdominal distension 20.29 18.85 31 4502 58461 34893937
Hyponatraemia 19.63 18.85 37 4496 82654 34869744

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 209.66 14.80 74 11519 11222 79721573
Chronic sinusitis 206.74 14.80 76 11517 12950 79719845
Paraesthesia oral 186.55 14.80 80 11513 20391 79712404
Procedural pain 167.84 14.80 77 11516 23007 79709788
Body tinea 111.68 14.80 30 11563 1824 79730971
Vaginal flatulence 110.76 14.80 32 11561 2543 79730252
Female genital tract fistula 95.29 14.80 35 11558 5940 79726855
Infection susceptibility increased 91.05 14.80 30 11563 3691 79729104
Inhibitory drug interaction 89.62 14.80 31 11562 4422 79728373
Proctitis 85.58 14.80 33 11560 6399 79726396
Radiculopathy 85.38 14.80 36 11557 8788 79724007
Therapeutic product effect incomplete 85.32 14.80 104 11489 141541 79591254
Vaginal discharge 77.42 14.80 32 11561 7431 79725364
Glucose tolerance impaired 68.40 14.80 30 11563 8054 79724741
Dyspepsia 67.37 14.80 81 11512 108606 79624189
Anal inflammation 67.01 14.80 19 11574 1411 79731384
Poor quality sleep 65.63 14.80 41 11552 22681 79710114
Removal of foreign body 64.12 14.80 11 11582 71 79732724
Impaired quality of life 57.42 14.80 32 11561 14354 79718441
Bone density decreased 56.88 14.80 31 11562 13316 79719479
SARS-CoV-2 test negative 54.38 14.80 16 11577 1355 79731440
Purpura 50.83 14.80 33 11560 19494 79713301
Local anaesthetic systemic toxicity 49.37 14.80 14 11579 1040 79731755
Hyperlipidaemia 48.85 14.80 36 11557 26057 79706738
Impaired work ability 43.39 14.80 30 11563 19651 79713144
Skin disorder 42.52 14.80 37 11556 33906 79698889
Appendicolith 42.48 14.80 22 11571 8529 79724266
Oral herpes 40.74 14.80 33 11560 27421 79705374
Pyrexia 39.71 14.80 199 11394 678510 79054285
Constipation 39.52 14.80 110 11483 282940 79449855
Proctalgia 39.24 14.80 22 11571 9979 79722816
Anaphylactic shock 38.70 14.80 36 11557 35960 79696835
Oral candidiasis 38.54 14.80 33 11560 29595 79703200
Ventricular fibrillation 38.39 14.80 34 11559 31892 79700903
Colitis ulcerative 37.84 14.80 35 11558 34707 79698088
Tracheal deviation 37.77 14.80 8 11585 173 79732622
Frequent bowel movements 36.60 14.80 32 11561 29507 79703288
Accident 36.22 14.80 20 11573 8811 79723984
Chemical burn 32.92 14.80 9 11584 584 79732211
Phrenic nerve paralysis 32.72 14.80 8 11585 333 79732462
Foreign body 32.03 14.80 13 11580 2881 79729914
Foreign body in respiratory tract 31.36 14.80 8 11585 397 79732398
Appendicitis 30.86 14.80 25 11568 20769 79712026
Cardiogenic shock 30.58 14.80 34 11559 41880 79690915
Herpes zoster 30.26 14.80 51 11542 93032 79639763
Methaemoglobinaemia 29.64 14.80 15 11578 5542 79727253
Cardiac arrest 26.10 14.80 69 11524 172027 79560768
Completed suicide 25.34 14.80 3 11590 245764 79487031
Colitis 24.94 14.80 41 11552 73266 79659529
Abdominal distension 24.63 14.80 54 11539 119596 79613199
Infusion related reaction 24.15 14.80 81 11512 230156 79502639
Kounis syndrome 24.14 14.80 12 11581 4270 79728525
Haemorrhoids 23.64 14.80 25 11568 29103 79703692
Rectal haemorrhage 22.43 14.80 40 11553 76260 79656535
Haematochezia 22.08 14.80 43 11550 87602 79645193
Cataract 21.48 14.80 35 11558 62085 79670710
Weight decreased 21.28 14.80 105 11488 355093 79377702
Rheumatoid arthritis 20.40 14.80 3 11590 208467 79524328
Nausea 20.21 14.80 220 11373 956976 78775819
Ascites 18.95 14.80 37 11556 75525 79657270
Cellulitis 17.84 14.80 45 11548 109015 79623780
Purtscher retinopathy 17.56 14.80 4 11589 122 79732673
Abdominal pain 17.18 14.80 106 11487 389463 79343332
Malaise 16.10 14.80 124 11469 489745 79243050
Anaesthetic complication 16.08 14.80 8 11585 2851 79729944
Arthritis bacterial 15.71 14.80 12 11581 9154 79723641
Administration related reaction 14.99 14.80 4 11589 237 79732558
Injection site infection 14.89 14.80 7 11586 2205 79730590

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.91 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021147 VUID
N0000179485 NUI
D04450 KEGG_DRUG
4021147 VANDF
C0304631 UMLSCUI
CHEBI:91642 CHEBI
CHEMBL1377575 ChEMBL_ID
DB11064 DRUGBANK_ID
C060446 MESH_SUPPLEMENTAL_RECORD_UI
8362 PUBCHEM_CID
3183 INN_ID
V06SV4M95S UNII
91326 RXNORM
001969 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0023-5501 LOTION 60 mg TOPICAL OTC monograph not final 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.12 g TOPICAL OTC monograph final 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.12 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.10 g TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.10 1 TOPICAL OTC monograph final 8 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.06 g TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 95 mg TOPICAL OTC monograph final 12 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 95 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 125 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 125 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Renew Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4136 LOTION 95 mg TOPICAL OTC monograph final 12 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 5 mg TOPICAL OTC monograph final 8 sections
Almay Best Blend Forever Makeup HUMAN OTC DRUG LABEL 4 0311-0719 LOTION 3.50 mg TOPICAL OTC monograph final 5 sections
Almay Healthy Biome Makeup HUMAN OTC DRUG LABEL 5 0311-0723 EMULSION 5 mg TOPICAL OTC monograph final 7 sections
Walgreens SPF 70 Sport Continuous HUMAN OTC DRUG LABEL 4 0363-0035 SPRAY 150 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 55 Sheer Face Mist Sunscreen HUMAN OTC DRUG LABEL 4 0363-0053 SPRAY 1000 mg TOPICAL OTC monograph not final 13 sections
Walgreens SPF 50 Clear Complexion Face Sunscreen HUMAN OTC DRUG LABEL 4 0363-0066 LOTION 40 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 50 Sport Faces HUMAN OTC DRUG LABEL 5 0363-0087 LOTION 130 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 50 Sport Faces HUMAN OTC DRUG LABEL 4 0363-0090 LOTION 130 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 30 Sport HUMAN OTC DRUG LABEL 4 0363-0093 LOTION 80 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 50 Sport Continuous Sunscreen HUMAN OTC DRUG LABEL 4 0363-0128 SPRAY 100 mg TOPICAL OTC monograph not final 12 sections
WALGREENS SPF 100 SHEER BODY SUNSCREEN MIST HUMAN OTC DRUG LABEL 4 0363-0135 AEROSOL, SPRAY 150 mg TOPICAL OTC monograph not final 13 sections
Walgreens SPF 50 Hydrating HUMAN OTC DRUG LABEL 4 0363-0136 LOTION 150 mg TOPICAL OTC monograph not final 11 sections
Walgreens SPF 30 Hydrating HUMAN OTC DRUG LABEL 4 0363-0146 LOTION 80 mg TOPICAL OTC monograph not final 12 sections
Walgreens Daytime Facial Moisturizer with Broad Spectrum SPF 30 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0187 LOTION 150 mg TOPICAL OTC monograph final 12 sections
WALGREENS 100 SHEER BROAD SPECTRUM SPF 100 HUMAN OTC DRUG LABEL 4 0363-0228 LOTION 150 mg TOPICAL OTC monograph final 12 sections
Walgreens Advanced 50 Clear Complexion Broad Spectrum SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0363-0231 LOTION 100 mg TOPICAL OTC monograph final 12 sections
WALGREENS 100 DRY TOUCH BROAD SPECTRUM SPF 100 FACE SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0232 LOTION 150 mg TOPICAL OTC monograph final 12 sections