gluconic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3264 526-95-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gluconic acid
  • D-Gluconic acid
  • dextronic acid
  • glycogenic acid
  • glyconic acid
  • maltonic acid
zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted
  • Molecular weight: 196.16
  • Formula: C6H12O7
  • CLOGP: -3.11
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 6
  • TPSA: 138.45
  • ALOGS: -0.09
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -3.511 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.265 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.589 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 0.449 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 85.680 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 86.450 % High 1
herg hERG pIC50 4.637 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.127 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.811 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 79.250 % High 1
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1 36
kinase-selectivity-class ACVRL1,AXL,BMX,BRAF,CDK1,CDK16,CDK2,CDK4,CDK9,CHUK,EPHB4,GRK2,INSR,IRAK3,JAK2,MAP2K6,MAP3K14,PIK3CB,PIK3CD,PIK3CG,PRKDC,SYK,TEK,TGFBR1,ZAP70 25
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.451 High 1
mh-clint Mouse hepatocyte intrinsic clearance 0.244 High 1
mppb Mouse plasma protein binding (% unbound) 96.360 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.834 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 92.040 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.455 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 93.050 % High 1
rppb Rat plasma protein binding (% unbound) 94.900 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 785.236 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:38161 chelator
CHEBI has role CHEBI:76964 <em>Penicillium</em> metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.73 acidic
pKa2 12.67 acidic
pKa3 13.1 acidic
pKa4 13.56 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018986 VUID
N0000179369 NUI
4018986 VANDF
C4082271 UMLSCUI
CHEBI:33198 CHEBI
GCO PDB_CHEM_ID
CHEMBL464345 ChEMBL_ID
DB13180 DRUGBANK_ID
10690 PUBCHEM_CID
C030691 MESH_SUPPLEMENTAL_RECORD_UI
R4R8J0Q44B UNII
2475956 RXNORM
7427 MMSL
002328 NDDF
49506005 SNOMEDCT_US

Pharmaceutical products:

None