benzonatate indications/contra

Stem definitionDrug idCAS RN
326 104-31-4

Description:

MoleculeDescription

Synonyms:

  • tessalon
  • benzonatate
  • benzononantin
  • benzononatine
  • Molecular weight:
  • Formula: (C2H4O)7-9C12H17NO2
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.60 g O

Approvals:

DateAgencyCompanyOrphan
Feb. 10, 1958 FDA PFIZER

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 251.99 56.58 61 201 35619 3349978
Completed suicide 249.55 56.58 59 203 31055 3354542
Toxicity to various agents 92.65 56.58 30 232 47024 3338573
Cardiac arrest 77.02 56.58 23 239 27296 3358301
Respiratory arrest 66.40 56.58 17 245 11351 3374246

Pharmacologic Action:

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SourceCodeDescription
ATC R05DB01 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
Other cough suppressants
FDA PE N0000009010 Decreased Tracheobronchial Stretch Receptor Activity
FDA EPC N0000175796 Non-narcotic Antitussive
MeSH PA D000996 Antitussive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:38867 anaesthetic
CHEBI has role CHEBI:51177 antitussive

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Cough indication 49727002

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel WOMBAT-PK

External reference:

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IDSource
C0740256 UMLSCUI
7611 IUPHAR_LIGAND_ID
D00242 KEGG_DRUG
5P4DHS6ENR UNII
651 INN_ID
DB00868 DRUGBANK_ID
4018542 VANDF
N0000146864 NDFRT
N0000005805 NDFRT
d00796 MMSL
4260 MMSL
18993 RXNORM
3024 MMSL
31801005 SNOMEDCT_US
386030001 SNOMEDCT_US
001663 NDDF
CHEMBL1374379 ChEMBL_ID
7699 PUBCHEM_CID
C029755 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:3032 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Tessalon HUMAN PRESCRIPTION DRUG LABEL 1 0069-0122 CAPSULE 100 mg ORAL NDA 12 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0179-0066 CAPSULE 100 mg ORAL ANDA 17 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0179-0237 CAPSULE 100 mg ORAL ANDA 16 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0440-1185 CAPSULE 100 mg ORAL ANDA 15 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0440-7185 CAPSULE 100 mg ORAL ANDA 16 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0440-7186 CAPSULE 200 mg ORAL ANDA 16 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0615-1349 CAPSULE 100 mg ORAL ANDA 12 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0615-7678 CAPSULE 100 mg ORAL ANDA 12 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0615-7887 CAPSULE 100 mg ORAL ANDA 16 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8143 CAPSULE 100 mg ORAL ANDA 16 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8194 CAPSULE 100 mg ORAL ANDA 16 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0904-5904 CAPSULE 100 mg ORAL ANDA 17 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0904-5905 CAPSULE 200 mg ORAL ANDA 17 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6254 CAPSULE, LIQUID FILLED 200 mg ORAL ANDA 12 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6564 CAPSULE 100 mg ORAL ANDA 12 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6657 CAPSULE 100 mg ORAL ANDA 16 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 10135-632 CAPSULE 200 mg ORAL ANDA 12 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 10544-094 CAPSULE 100 mg ORAL ANDA 16 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 10544-123 CAPSULE 200 mg ORAL ANDA 16 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 10544-129 CAPSULE 100 mg ORAL ANDA 16 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 12634-826 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 12 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 16590-031 CAPSULE 100 mg ORAL ANDA 11 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 21695-191 CAPSULE 100 mg ORAL ANDA 16 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 21695-760 CAPSULE 200 mg ORAL ANDA 16 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 33261-147 CAPSULE 100 mg ORAL ANDA 16 sections
benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 33261-634 CAPSULE 200 mg ORAL ANDA 16 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 35356-863 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 12 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 42254-078 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 11 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 42291-164 CAPSULE, LIQUID FILLED 100 mg ORAL ANDA 12 sections
Benzonatate HUMAN PRESCRIPTION DRUG LABEL 1 42291-165 CAPSULE, LIQUID FILLED 200 mg ORAL ANDA 12 sections