benziodarone indications/contra

Stem definitionDrug idCAS RN
antiarrhythmics 321 68-90-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benziodarone
  • cardivix
  • dilafurane
minor descriptor (75-89); on-line & INDEX MEDICUS search BENZOFURANS (68-89) & IODOBENZOATES (74)
  • Molecular weight: 518.09
  • Formula: C17H12I2O3
  • CLOGP: 6.36
  • LIPINSKI: 2
  • HAC: 3
  • HDO: 1
  • TPSA: 50.44
  • ALOGS: -4.57
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.25 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC C01DX04 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Other vasodilators used in cardiac diseases
ATC C01DX54 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Other vasodilators used in cardiac diseases
MeSH PA D018501 Antirheumatic Agents
MeSH PA D006074 Gout Suppressants
MeSH PA D012076 Renal Agents
MeSH PA D014528 Uricosuric Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.81 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Baculoviral IAP repeat-containing protein 5 Unclassified Kd 5.10 CHEMBL

External reference:

scroll-->
IDSource
D01833 KEGG_DRUG
75CL65GTYR UNII
984 INN_ID
CHEMBL232201 ChEMBL_ID
6237 PUBCHEM_CID
C058702 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135814 CHEBI

Pharmaceutical products:

None