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benziodarone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiarrhythmics | 321 | 68-90-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
minor descriptor (75-89); on-line & INDEX MEDICUS search BENZOFURANS (68-89) & IODOBENZOATES (74)
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.25 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
| S (Water solubility) | 0.01 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 4.144 | Moderate | 0.69 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.962 | Moderate | 0.69 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 14.093 | 10^-6 cm/s | Moderate | 0.69 |
| dh-clint | Dog hepatocyte intrinsic clearance | 19.055 | uL/min/10^6 cells | Moderate | 0.69 |
| dppb | Dog plasma protein binding (% unbound) | 0.150 | % | Moderate | 0.69 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 0.190 | % | Moderate | 0.69 |
| herg | hERG pIC50 | 4.882 | pIC50 | Moderate | 0.69 |
| hh-clint | Human hepatocyte intrinsic clearance | 18.030 | uL/min/10^6 cells | Moderate | 0.69 |
| hlm-clint | Human liver microsomal intrinsic clearance | 37.670 | uL/min/mg protein | Moderate | 0.69 |
| hppb | Human plasma protein binding (% unbound) | 1.020 | % | Moderate | 0.69 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 5.821 | Moderate | 0.69 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 28.314 | Moderate | 0.69 | |
| mppb | Mouse plasma protein binding (% unbound) | 0.190 | Moderate | 0.69 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 1.315 | Moderate | 0.69 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 1 | Moderate | 0.74 | |
| pppb | Pig plasma protein binding (% unbound) | 0.140 | % | Moderate | 0.69 |
| rh-clint | Rat hepatocyte intrinsic clearance | 47.973 | uL/min/10^6 cells | Moderate | 0.69 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 1.740 | % | Moderate | 0.69 |
| rppb | Rat plasma protein binding (% unbound) | 0.160 | % | Moderate | 0.69 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 31.333 | uM | Moderate | 0.69 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01DX04 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Other vasodilators used in cardiac diseases |
| ATC | C01DX54 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Other vasodilators used in cardiac diseases |
| MeSH PA | D006074 | Gout Suppressants |
| MeSH PA | D014528 | Uricosuric Agents |
| MeSH PA | D018501 | Antirheumatic Agents |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
Related Drugs by ATC class:
C01DX Other vasodilators used in cardiac diseases 18 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.81 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Transthyretin | Secreted | Kd | 7.11 | CHEMBL | |||||
| Baculoviral IAP repeat-containing protein 5 | Cytosolic other | Kd | 5.10 | CHEMBL | |||||
| Eyes absent homolog 3 | Enzyme | IC50 | 5.47 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01833 | KEGG_DRUG |
| C0053185 | UMLSCUI |
| PJO | PDB_CHEM_ID |
| CHEMBL232201 | ChEMBL_ID |
| DB13277 | DRUGBANK_ID |
| C058702 | MESH_SUPPLEMENTAL_RECORD_UI |
| 984 | INN_ID |
| 75CL65GTYR | UNII |
| 6237 | PUBCHEM_CID |
| CHEBI:135814 | CHEBI |
Pharmaceutical products:
None