nordefrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3203 74812-63-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cobefrin
  • nordefrin
  • nordefrin hydrochloride
  • nordefrin HCl
A norepinephrine derivative used as a vasoconstrictor agent.
  • Molecular weight: 183.21
  • Formula: C9H13NO3
  • CLOGP: -0.68
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 86.71
  • ALOGS: -1.10
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014662 Vasoconstrictor Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.45 acidic
pKa2 12.29 acidic
pKa3 12.9 acidic
pKa4 8.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha-2 GPCR Ki 8.11 CHEMBL

External reference:

IDSource
61-96-1 SECONDARY_CAS_RN
CHEBI:81386 CHEBI
CHEMBL677 ChEMBL_ID
CHEMBL764 ChEMBL_ID
CHEMBL1612659 ChEMBL_ID
R81X549E70 UNII
387230002 SNOMEDCT_US
C0025805 UMLSCUI
D008771 MESH_DESCRIPTOR_UI
164739 PUBCHEM_CID

Pharmaceutical products:

None