estriol Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
estrogens 3187 50-27-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • estriol
  • destriol
  • estratriol
  • ovestrion
A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
  • Molecular weight: 288.39
  • Formula: C18H24O3
  • CLOGP: 3.20
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 60.69
  • ALOGS: -3.38
  • ROTB: 0

Drug dosage:

DoseUnitRoute
2 mg O
2 mg P
0.20 mg V

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC G03CA04 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
ESTROGENS
Natural and semisynthetic estrogens, plain
ATC G03CC06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
ESTROGENS
Estrogens, combinations with other drugs

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.13 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Estrogen receptor Nuclear hormone receptor AGONIST Ki 8.67 IUPHAR IUPHAR
Glucocorticoid receptor Nuclear hormone receptor Ki 4.75 DRUG MATRIX
Sex hormone-binding globulin Secreted Kd 6.63 CHEMBL
Estrogen receptor beta Nuclear hormone receptor AGONIST Ki 8.40 IUPHAR
Sodium-dependent serotonin transporter Transporter Ki 5.26 DRUG MATRIX
Corticosteroid-binding globulin Secreted Ki 5 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 5.06 DRUG MATRIX
Lanosterol 14-alpha demethylase Enzyme Kd 4 CHEMBL

External reference:

IDSource
2821 IUPHAR_LIGAND_ID
N0000167513 NUI
C0014927 UMLSCUI
D00185 KEGG_DRUG
5756 PUBCHEM_CID
4094 RXNORM
73723004 SNOMEDCT_US
354050008 SNOMEDCT_US
NOCODE MMSL
132550 MMSL
18220 MMSL
d05027 MMSL
N0000167513 NDFRT
001285 NDDF
708043004 SNOMEDCT_US
CHEMBL193482 ChEMBL_ID
CHEBI:27974 CHEBI
D004964 MESH_DESCRIPTOR_UI
DB04573 DRUGBANK_ID
FB33469R8E UNII
ESL PDB_CHEM_ID

Pharmaceutical products:

None