dihydroergocornine indications/contra

Stem definitionDrug idCAS RN
ergot alkaloid derivatives 3184 25447-65-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dihydroergocornine
  • 9,10-Dihydroergocornine
  • dihydroergocornine mesylate
  • dihydroergocornine mesilate
A 9,10alpha-dihydro derivative of ERGOTAMINE that contains isopropyl sidechains at the 2' and 5' positions of the molecule.
  • Molecular weight: 563.70
  • Formula: C31H41N5O5
  • CLOGP: 5.07
  • LIPINSKI: 2
  • HAC: 10
  • HDO: 3
  • TPSA: 118.21
  • ALOGS: -3.15
  • ROTB: 4

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D015259 Dopamine Agents
MeSH PA D018491 Dopamine Agonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Dementia indication 52448006

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.64 acidic
pKa2 13.29 acidic
pKa3 13.84 acidic
pKa4 7.56 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
4017833 VUID
N0000146191 NUI
C0012288 UMLSCUI
42RX8KPW29 UNII
29261-94-7 SECONDARY_CAS_RN
3415 RXNORM
19918001 SNOMEDCT_US
4017833 VANDF
N0000146191 NDFRT
N0000004681 NDFRT
168871 PUBCHEM_CID
D025441 MESH_DESCRIPTOR_UI
CHEBI:59909 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Ergoloid Mesylates HUMAN PRESCRIPTION DRUG LABEL 4 53489-281 TABLET 0.33 mg ORAL ANDA 10 sections
Ergoloid Mesylates HUMAN PRESCRIPTION DRUG LABEL 4 68151-2780 TABLET 0.33 mg ORAL ANDA 10 sections