benzbromarone indications/contra

Stem definitionDrug idCAS RN
antiarrhythmics 318 3562-84-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzbromarone
  • benzbromaron
  • azubromaron
Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.
  • Molecular weight: 424.08
  • Formula: C17H12Br2O3
  • CLOGP: 5.98
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 50.44
  • ALOGS: -4.51
  • RINGS: 3
  • ROTB: 3

Drug dosage:

DoseUnitRoute
100 mg O

Approvals:

None

Pharmacologic Action:

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SourceCodeDescription
ATC M04AB03 MUSCULO-SKELETAL SYSTEM
ANTIGOUT PREPARATIONS
ANTIGOUT PREPARATIONS
Preparations increasing uric acid excretion
MeSH PA D018501 Antirheumatic Agents
MeSH PA D006074 Gout Suppressants
CHEBI has role CHEBI:35841 uricosuric drug
MeSH PA D012076 Renal Agents
MeSH PA D014528 Uricosuric Agents

Drug Use (View source of the data)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2B GPCR Ki 5.94 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 5.53 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 7.80 DRUG MATRIX
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Enzyme IC50 5.98 DRUG MATRIX
Mitogen-activated protein kinase 14 Kinase IC50 5.91 DRUG MATRIX
Mitogen-activated protein kinase 1 Kinase IC50 5.71 DRUG MATRIX
Multidrug resistance-associated protein 1 Transporter Ki 6.72 CHEMBL
Aldo-keto reductase family 1 member C1 Enzyme IC50 7.32 CHEMBL
Solute carrier family 22 member 12 Transporter IC50 7.59 CHEMBL
Envelope glycoprotein gp160 Unclassified IC50 4.89 CHEMBL
M1-family alanyl aminopeptidase Unclassified IC50 4.20 CHEMBL

External reference:

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IDSource
N0000166974 NDFRT
005311 NDDF
1385 RXNORM
698025001 SNOMEDCT_US
703372005 SNOMEDCT_US
DB12319 DRUGBANK_ID
D001553 MESH_DESCRIPTOR_UI
D01056 KEGG_DRUG
1427 INN_ID
4POG0RL69O UNII
CHEBI:3023 CHEBI
2333 PUBCHEM_CID
CHEMBL388590 ChEMBL_ID
N0000166974 NUI
C0005035 UMLSCUI

Pharmaceutical products:

None