enilconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 3177 35554-44-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • enilconazole
  • imazalil
  • bromazil
  • deccozil
  • imazalil phosphate
  • imazalil sulfate
  • imazalil mononitrate
  • Molecular weight: 297.18
  • Formula: C14H14Cl2N2O
  • CLOGP: 3.65
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 27.05
  • ALOGS: -3.92
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.519 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.239 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 48.417 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 21.528 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 1.560 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 4.300 % High 1
herg hERG pIC50 5.634 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 14.689 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 35.563 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 1.940 % High 1
kinase-safety-class ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP3K7,MAPK7,MAPK9,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PRKDC,SIK2,STK33,SYK,TEK 32
kinase-selectivity-class AXL,BRAF,GRK2,PDK4 4
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.610 High 1
mh-clint Mouse hepatocyte intrinsic clearance 79.983 High 1
mppb Mouse plasma protein binding (% unbound) 1.830 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.213 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 3.780 % High 1
rh-clint Rat hepatocyte intrinsic clearance 52.240 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 21.440 % High 1
rppb Rat plasma protein binding (% unbound) 1.680 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 517.607 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D005659 Fungicides, Industrial
MeSH PA D010575 Pesticides
CHEBI has role CHEBI:77884 EC 1.14.13.70 (sterol 14α-demethylase) inhibitor
CHEBI has role CHEBI:86328 antifungal agrochemical

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 4.64 CHEMBL

External reference:

IDSource
D03997 KEGG_DRUG
C0063371 UMLSCUI
CHEBI:81927 CHEBI
CHEMBL356918 ChEMBL_ID
C017435 MESH_SUPPLEMENTAL_RECORD_UI
37175 PUBCHEM_CID
4921 INN_ID
6K0NOF3XQ6 UNII
1442172 RXNORM
6K0NOF3XQ6 INXIGHT DRUGS

Pharmaceutical products:

None