benzarone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiarrhythmics | 317 | 1477-19-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
antihemorrhagic agent; structure
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
| S (Water solubility) | 0.02 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D005343 | Fibrinolytic Agents |
| MeSH PA | D006401 | Hematologic Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.12 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 12 | Transporter | IC50 | 5.55 | CHEMBL | |||||
| Eyes absent homolog 3 | Enzyme | IC50 | 4.77 | CHEMBL | |||||
| Eyes absent homolog 3 | Enzyme | IC50 | 4.72 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 18923 | RXNORM |
| C0053152 | UMLSCUI |
| CHEBI:34559 | CHEBI |
| CHEMBL1474963 | ChEMBL_ID |
| C004528 | MESH_SUPPLEMENTAL_RECORD_UI |
| 255968 | PUBCHEM_CID |
| 1426 | INN_ID |
| 23ZW4BG89C | UNII |
Pharmaceutical products:
None