diiodotyrosine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
3146 300-39-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • L-3,5-diiodotyrosine
  • agontan
  • apothyrin
  • cemiod
  • DL-3,5-Diiodotyrosine
  • dityrin
  • iodogorgoic acid
  • iodogorgonic acid
  • jodgorgon
  • diiodotyrosine
A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE).
  • Molecular weight: 432.98
  • Formula: C9H9I2NO3
  • CLOGP: -0.28
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 83.55
  • ALOGS: -2.92
  • ROTB: 3

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC H03BX01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
ANTITHYROID PREPARATIONS
Other antithyroid preparations

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.08 acidic
pKa2 6.33 acidic
pKa3 8.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
6L57Q44ZWW UNII
80393001 SNOMEDCT_US
N0000170245 NDFRT
007143 NDDF
9305 PUBCHEM_CID
CHEMBL1236469 ChEMBL_ID
D004105 MESH_DESCRIPTOR_UI
CHEBI:15768 CHEBI
TYI PDB_CHEM_ID

Pharmaceutical products:

None