diiodotyrosine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
radiopharmaceuticals, iodine-contained 3146 300-39-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • L-3,5-diiodotyrosine
  • agontan
  • apothyrin
  • cemiod
  • DL-3,5-Diiodotyrosine
  • dityrin
  • iodogorgoic acid
  • iodogorgonic acid
  • jodgorgon
  • diiodotyrosine
A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE).
  • Molecular weight: 432.98
  • Formula: C9H9I2NO3
  • CLOGP: -0.28
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 83.55
  • ALOGS: -2.92
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H03BX01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
ANTITHYROID PREPARATIONS
Other antithyroid preparations
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.08 acidic
pKa2 6.33 acidic
pKa3 8.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
CHEBI:15768 CHEBI
TYI PDB_CHEM_ID
CHEMBL1236469 ChEMBL_ID
6L57Q44ZWW UNII
007143 NDDF
80393001 SNOMEDCT_US
C0012344 UMLSCUI
D004105 MESH_DESCRIPTOR_UI
DB03374 DRUGBANK_ID
9305 PUBCHEM_CID

Pharmaceutical products:

None