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diphenidol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 313 | 972-02-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
shows anti-arrhythmic activity; RN given refers to unlabeled parent cpd
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 5, 1967 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA PE | N0000009034 | Emesis Suppression |
| MeSH PA | D000932 | Antiemetics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| CHEBI has role | CHEBI:50919 | antiemetic |
| FDA EPC | N0000178372 | Antiemetic |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Vertigo | indication | 399153001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.28 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | GPCR | ANTAGONIST | Ki | 7.11 | DRUG MATRIX | CHEMBL | |||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.97 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.13 | DRUG MATRIX | |||||
| D(3) dopamine receptor | GPCR | Ki | 6.11 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.56 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.28 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.42 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 6.07 | DRUG MATRIX | |||||
| Cytochrome P450 2D6 | Enzyme | IC50 | 6.49 | DRUG MATRIX | |||||
| D(2) dopamine receptor | GPCR | Ki | 5.96 | DRUG MATRIX | |||||
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 5.47 | CHEMBL | |||||
| Alpha-1B adrenergic receptor | GPCR | Ki | 5.58 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| D01318 | KEGG_DRUG |
| 23370 | RXNORM |
| CHEBI:4638 | CHEBI |
| CHEMBL936 | ChEMBL_ID |
| CHEMBL1529 | ChEMBL_ID |
| C004858 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7163 | IUPHAR_LIGAND_ID |
| 3254-89-5 | SECONDARY_CAS_RN |
| DB01231 | DRUGBANK_ID |
| NQO8R319LY | UNII |
| C0058371 | UMLSCUI |
| 1433 | INN_ID |
| 3055 | PUBCHEM_CID |
| 4018019 | VANDF |
| 4019725 | VANDF |
| 001681 | NDDF |
| 001682 | NDDF |
| 32030002 | SNOMEDCT_US |
| 63779001 | SNOMEDCT_US |
| 767579009 | SNOMEDCT_US |
| NQO8R319LY | INXIGHT DRUGS |
Pharmaceutical products:
None