diphenidol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
313 972-02-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cephadol
  • difenidol
  • diphenadol
  • lansenol
  • diphenidol hydrochloride
  • diphenidol
  • difenidol hydrochloride
  • difenidol embonate
  • diphenidol HCl
  • difenidol HCl
shows anti-arrhythmic activity; RN given refers to unlabeled parent cpd
  • Molecular weight: 309.45
  • Formula: C21H27NO
  • CLOGP: 4.07
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 23.47
  • ALOGS: -4.72
  • ROTB: 6

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 5, 1967 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA PE N0000009034 Emesis Suppression
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:50919 antiemetico
FDA EPC N0000178372 Antiemetic

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vertigo indication 399153001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.28 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST Ki 7.11 DRUG MATRIX CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.97 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.13 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.11 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.56 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 7.28 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 7.42 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 6.07 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.49 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 5.96 DRUG MATRIX
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.47 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 5.58 DRUG MATRIX

External reference:

IDSource
D01318 KEGG_DRUG
3254-89-5 SECONDARY_CAS_RN
23370 RXNORM
CHEBI:4638 CHEBI
CHEMBL936 ChEMBL_ID
C004858 MESH_SUPPLEMENTAL_RECORD_UI
7163 IUPHAR_LIGAND_ID
1433 INN_ID
DB01231 DRUGBANK_ID
NQO8R319LY UNII
32030002 SNOMEDCT_US
63779001 SNOMEDCT_US
767579009 SNOMEDCT_US
C0058371 UMLSCUI
CHEMBL1529 ChEMBL_ID
4018019 VANDF
4019725 VANDF
3055 PUBCHEM_CID
001681 NDDF
001682 NDDF

Pharmaceutical products:

None