dantron indications/contra

Stem definitionDrug idCAS RN
3125 117-10-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • danthron
  • antrapurol
  • chrysazin
  • danthrone
  • dantron
  • diaquone
  • dionone
  • laxanorm
  • laxanthreen
  • 1,8-Dihydroxyanthraquinone
mild purgative anthraquinone derivative chemically related to emodin, the active principle of cascara and other naturally occurring products such as senna, aloes and rhubarb, it acts on the nerve endings of the myenteric plexus and stimulates the muscles of the large intestine
  • Molecular weight: 240.21
  • Formula: C14H8O4
  • CLOGP: 3.74
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 74.60
  • ALOGS: -2.90
  • ROTB: 0

Drug dosage:

DoseUnitRoute
50 mg O

Approvals:

DateAgencyCompanyOrphan
Oct. 19, 1994 UK Medicines and Healthcare Products Regulatory Agency (MHRA) Napp Pharmaceuticals Ltd

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A06AB03 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Contact laxatives
ATC A06AB53 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Contact laxatives
ATC A06AG03 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
MeSH PA D002400 Cathartics
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D009153 Mutagens
MeSH PA D009676 Noxae

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Incontinence of feces contraindication 72042002
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal obstruction contraindication 126765001
Urinary incontinence contraindication 165232002

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.56 acidic
pKa2 9.34 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
4018988 VUID
N0000179096 NUI
C0057135 UMLSCUI
D07107 KEGG_DRUG
CHEMBL53418 ChEMBL_ID
2950 PUBCHEM_CID
4018988 VANDF
N0000179096 NDFRT
N0000147265 NDFRT
22293 RXNORM
387364000 SNOMEDCT_US
65884003 SNOMEDCT_US
001171 NDDF
CHEBI:3682 CHEBI
DB04816 DRUGBANK_ID
C004315 MESH_SUPPLEMENTAL_RECORD_UI
Z4XE6IBF3V UNII
81 INN_ID
CHZ PDB_CHEM_ID

Pharmaceutical products:

None