dantron 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3125 | 117-10-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
mild purgative anthraquinone derivative chemically related to emodin, the active principle of cascara and other naturally occurring products such as senna, aloes and rhubarb, it acts on the nerve endings of the myenteric plexus and stimulates the muscles of the large intestine
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 50 | mg | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 19, 1994 | UK Medicines and Healthcare Products Regulatory Agency (MHRA) | Napp Pharmaceuticals Ltd |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A06AB03 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives |
| ATC | A06AB53 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives |
| ATC | A06AG03 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas |
| MeSH PA | D002400 | Cathartics |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D009153 | Mutagens |
| MeSH PA | D009676 | Noxae |
| CHEBI has role | CHEBI:68495 | Type I cell-death inducers |
| CHEBI has role | CHEBI:76924 | plant metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Constipation | indication | 14760008 | DOID:2089 |
| Incontinence of feces | contraindication | 72042002 | |
| Appendicitis | contraindication | 74400008 | DOID:8337 |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Urinary incontinence | contraindication | 165232002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.56 | acidic |
| pKa2 | 9.34 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] B | Enzyme | IC50 | 4.23 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | IC50 | 4.97 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018988 | VUID |
| N0000179096 | NUI |
| D07107 | KEGG_DRUG |
| 4018988 | VANDF |
| C0057135 | UMLSCUI |
| CHEBI:3682 | CHEBI |
| CHZ | PDB_CHEM_ID |
| CHEMBL53418 | ChEMBL_ID |
| DB04816 | DRUGBANK_ID |
| C004315 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2950 | PUBCHEM_CID |
| 22293 | RXNORM |
| 001171 | NDDF |
| 387364000 | SNOMEDCT_US |
| 65884003 | SNOMEDCT_US |
| 81 | INN_ID |
| Z4XE6IBF3V | UNII |
Pharmaceutical products:
None