benoxaprofen indications/contra

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 311 51234-28-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benoxaprofen ammonium
  • benoxaprofen monosodium
  • benoxaprofen sodium
  • oraflex
  • benoxaprofen
  • dl-Benoxaprofen
  • Molecular weight: 301.73
  • Formula: C16H12ClNO3
  • CLOGP: 3.82
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.33
  • ALOGS: -3.98
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
April 19, 1982 FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC M01AE06 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35493 antipyretic
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:50748 antipsoriatic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D016859 Lipoxygenase Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

scroll-->
DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.05 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Arachidonate 5-lipoxygenase Enzyme INHIBITOR KEGG DRUG KEGG DRUG
Bile salt export pump Unclassified IC50 4 CHEMBL

External reference:

scroll-->
IDSource
D03080 KEGG_DRUG
17SZX404IM UNII
3896 INN_ID
396197001 SNOMEDCT_US
002390 NDDF
70062-36-1 SECONDARY_CAS_RN
CHEMBL340978 ChEMBL_ID
39941 PUBCHEM_CID
CHEBI:76114 CHEBI
DB04812 DRUGBANK_ID
C011677 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None