cinchophen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 3101 132-60-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phenylcinchoninic acid
  • cincain
  • cinchophen
  • aciphenochinoline
  • aciphenochinolinium
  • cinchophene
  • cinchophenic acid
  • cinconal
  • cincophen
  • phenoquin
  • quinofen
  • quinophan
  • quinophen
  • Molecular weight: 249.27
  • Formula: C16H11NO2
  • CLOGP: 4.28
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 50.19
  • ALOGS: -3.85
  • ROTB: 2

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.16 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M04AC02 MUSCULO-SKELETAL SYSTEM
ANTIGOUT PREPARATIONS
ANTIGOUT PREPARATIONS
Preparations with no effect on uric acid metabolism
MeSH PA D000777 Anesthetics
MeSH PA D000779 Anesthetics, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gout indication 90560007 DOID:13189




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.35 acidic
pKa2 4.7 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Enzyme Kd 3.90 CHEMBL

External reference:

IDSource
D07280 KEGG_DRUG
C0008793 UMLSCUI
CHEBI:114195 CHEBI
CHEMBL348000 ChEMBL_ID
DB13551 DRUGBANK_ID
C084834 MESH_SUPPLEMENTAL_RECORD_UI
8593 PUBCHEM_CID
1332 INN_ID
39Y533Z02M UNII
61709008 SNOMEDCT_US
D003992 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None