choline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3097 | 62-49-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D000960 | Hypolipidemic Agents |
| MeSH PA | D057847 | Lipid Regulating Agents |
| MeSH PA | D008082 | Lipotropic Agents |
| MeSH PA | D018697 | Nootropic Agents |
| CHEBI has role | CHEBI:25512 | neurotransmitters |
| CHEBI has role | CHEBI:33284 | nutrients |
| CHEBI has role | CHEBI:50904 | alergeno |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:75772 | S. cerevisiae metabolites |
| CHEBI has role | CHEBI:76924 | plant metabolites |
| CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:83056 | Daphnia magna metabolites |
| CHEBI has role | CHEBI:82655 | animal growth promotants |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Insomnia | indication | 193462001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholine receptor subunit delta | Ion channel | Ki | 4.38 | CHEMBL | |||||
| High affinity choline transporter 1 | Transporter | IC50 | 5.80 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha2/beta2 | Ion channel | Ki | 4.74 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha3/beta2 | Ion channel | Ki | 4.43 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha3/beta4 | Ion channel | Ki | 4.32 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha4/beta2 | Ion channel | Ki | 4.43 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha4/beta4 | Ion channel | Ki | 4.47 | CHEMBL | |||||
| Creatine transporter | Transporter | Ki | 4.38 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N91BDP6H0X | UNII |
| 4020078 | VUID |
| N0000178902 | NUI |
| D07690 | KEGG_DRUG |
| 67-48-1 | SECONDARY_CAS_RN |
| 87-67-2 | SECONDARY_CAS_RN |
| 4017687 | VANDF |
| 4017699 | VANDF |
| 4020077 | VANDF |
| 4020078 | VANDF |
| C0008405 | UMLSCUI |
| CHEBI:15354 | CHEBI |
| CHT | PDB_CHEM_ID |
| CHEMBL920 | ChEMBL_ID |
| 305 | PUBCHEM_CID |
| DB00122 | DRUGBANK_ID |
| CHEMBL282468 | ChEMBL_ID |
| D002794 | MESH_DESCRIPTOR_UI |
| 4551 | IUPHAR_LIGAND_ID |
| 1425426 | RXNORM |
| 4436 | MMSL |
| 4437 | MMSL |
| 4875 | MMSL |
| 4880 | MMSL |
| NOCODE | MMSL |
| d03064 | MMSL |
| d03159 | MMSL |
| 002058 | NDDF |
| 002059 | NDDF |
| 005105 | NDDF |
| 111156002 | SNOMEDCT_US |
| 387030006 | SNOMEDCT_US |
| 427976002 | SNOMEDCT_US |
| 65123005 | SNOMEDCT_US |
| CHEMBL2105935 | ChEMBL_ID |
| 442 | INN_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| NESTABSPrenatal Multi-vitamin/Mineral Supplement | HUMAN PRESCRIPTION DRUG LABEL | 15 | 50967-219 | TABLET, FILM COATED | 55 mg | ORAL | unapproved drug other | 8 sections |
| NESTABSPrenatal Multi-vitamin/Mineral Supplement | HUMAN PRESCRIPTION DRUG LABEL | 15 | 50967-219 | TABLET, FILM COATED | 55 mg | ORAL | unapproved drug other | 8 sections |
| Prenatrix | HUMAN PRESCRIPTION DRUG LABEL | 20 | 59088-166 | TABLET | 55 mg | ORAL | unapproved drug other | 13 sections |
| Prenatrix | HUMAN PRESCRIPTION DRUG LABEL | 20 | 59088-166 | TABLET | 55 mg | ORAL | unapproved drug other | 13 sections |
| Prenatryl | HUMAN PRESCRIPTION DRUG LABEL | 20 | 59088-169 | TABLET | 55 mg | ORAL | unapproved drug other | 13 sections |
| Prenatryl | HUMAN PRESCRIPTION DRUG LABEL | 20 | 59088-169 | TABLET | 55 mg | ORAL | unapproved drug other | 13 sections |
| Prometa | HUMAN PRESCRIPTION DRUG LABEL | 20 | 59088-172 | TABLET | 55 mg | ORAL | unapproved drug other | 13 sections |
| Prometa | HUMAN PRESCRIPTION DRUG LABEL | 20 | 59088-172 | TABLET | 55 mg | ORAL | unapproved drug other | 13 sections |
| Pretrate | HUMAN PRESCRIPTION DRUG LABEL | 20 | 59088-178 | TABLET | 55 mg | ORAL | unapproved drug other | 13 sections |
| Pretrate | HUMAN PRESCRIPTION DRUG LABEL | 20 | 59088-178 | TABLET | 55 mg | ORAL | unapproved drug other | 13 sections |
| Lipovite | HUMAN PRESCRIPTION DRUG LABEL | 13 | 70104-128 | INJECTION | 1 mg | INTRAMUSCULAR | unapproved drug other | 1 sections |