chloroxylenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3094	88-04-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: chloroxylenol sodium chloroxylenol benzytol parametaxylenol	a antiseptic halogenated phenol, non-toxic, non-corrosive, non-staining with high phenol coefficient, it may be applied directly to a wound and shows no chemical reactivity toward blood Molecular weight: 156.61 Formula: C8H9ClO CLOGP: 3.48 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: -2.26 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

chloroxylenol sodium
chloroxylenol
benzytol
parametaxylenol

a antiseptic halogenated phenol, non-toxic, non-corrosive, non-staining with high phenol coefficient, it may be applied directly to a wound and shows no chemical reactivity toward blood

Molecular weight: 156.61
Formula: C8H9ClO
CLOGP: 3.48
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 20.23
ALOGS: -2.26
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	6856.07	25.31	2248	16246	143425	63327103
Toxicity to various agents	4132.56	25.31	1795	16699	245455	63225073
Drug abuse	2241.18	25.31	826	17668	71692	63398836
Cardio-respiratory arrest	1337.84	25.31	540	17954	59419	63411109
Intentional overdose	1233.63	25.31	542	17952	73610	63396918
Overdose	918.06	25.31	510	17984	114568	63355960
Suicide attempt	774.96	25.31	370	18124	60548	63409980
Alcohol interaction	529.13	25.31	126	18368	2283	63468245
Suspected suicide	467.73	25.31	141	18353	6427	63464101
Respiratory arrest	377.42	25.31	186	18308	32459	63438069
Intentional product misuse	373.09	25.31	228	18266	60689	63409839
Cardiac arrest	353.15	25.31	258	18236	92287	63378241
Death	308.72	25.31	456	18038	373925	63096603
Exposure to toxic agent	289.15	25.31	94	18400	5493	63465035
Alcohol poisoning	273.64	25.31	71	18423	1848	63468680
Alcohol use	234.98	25.31	64	18430	2015	63468513
Coma	215.36	25.31	166	18328	64198	63406330
Somnolence	195.43	25.31	250	18244	178435	63292093
Alcohol abuse	187.48	25.31	54	18440	2092	63468436
Drug ineffective	177.10	25.31	44	18450	1044721	62425807
Agitation	131.31	25.31	121	18373	59636	63410892
Pain	123.59	25.31	32	18462	740596	62729932
Mydriasis	120.09	25.31	62	18432	11894	63458634
Poisoning deliberate	117.97	25.31	60	18434	11158	63459370
Loss of consciousness	116.14	25.31	157	18337	117964	63352564
Diarrhoea	113.57	25.31	34	18460	715332	62755196
Poisoning	103.99	25.31	59	18435	13641	63456887
Alcoholism	103.92	25.31	33	18461	1785	63468743
Substance abuse	102.29	25.31	42	18452	4765	63465763
Arthralgia	102.11	25.31	21	18473	569689	62900839
Fatigue	99.48	25.31	69	18425	887959	62582569
Blood alcohol increased	92.35	25.31	24	18470	628	63469900
Myocarditis	90.81	25.31	49	18445	10276	63460252
Seizure	89.73	25.31	148	18346	132486	63338042
Intentional self-injury	89.65	25.31	68	18426	25619	63444909
Rash	88.28	25.31	27	18467	560844	62909684
Drug dependence	88.08	25.31	66	18428	24417	63446111
Postmortem blood drug level abnormal	85.24	25.31	20	18474	338	63470190
Dyspnoea	79.91	25.31	47	18447	661266	62809262
Suicidal ideation	78.76	25.31	94	18400	62327	63408201
Victim of sexual abuse	77.02	25.31	21	18473	663	63469865
Alopecia	75.78	25.31	6	18488	337530	63132998
Drug use disorder	74.70	25.31	34	18460	4950	63465578
Chemical submission	68.44	25.31	16	18478	266	63470262
Drug intolerance	67.86	25.31	6	18488	308655	63161873
Drug interaction	67.68	25.31	182	18312	228949	63241579
Abdominal discomfort	66.00	25.31	8	18486	320877	63149651
Headache	65.83	25.31	53	18441	633188	62837340
Off label use	64.62	25.31	61	18433	674401	62796127
Aggression	64.44	25.31	54	18440	23444	63447084
Pain in extremity	64.09	25.31	10	18484	331476	63139052
Hypersensitivity	63.50	25.31	6	18488	292679	63177849
Depressed level of consciousness	63.21	25.31	84	18410	61994	63408534
Pneumonia	61.71	25.31	28	18466	456739	63013789
Swelling	61.49	25.31	5	18489	275373	63195155
Drug withdrawal syndrome	59.56	25.31	55	18439	27139	63443389
Pruritus	59.36	25.31	16	18478	361437	63109091
Pyrexia	58.80	25.31	32	18462	470446	63000082
Rheumatoid arthritis	58.40	25.31	4	18490	253815	63216713
Condition aggravated	56.96	25.31	23	18471	402194	63068334
Peripheral swelling	53.77	25.31	7	18487	265935	63204593
Somnambulism	53.52	25.31	28	18466	5515	63465013
Arthropathy	50.42	25.31	5	18489	234787	63235741
Congestive hepatopathy	50.27	25.31	22	18472	2920	63467608
Electrocardiogram ST segment elevation	50.20	25.31	24	18470	3903	63466625
Tachycardia	50.07	25.31	108	18386	118048	63352480
Nasopharyngitis	48.38	25.31	8	18486	254249	63216279
Product administration interrupted	48.33	25.31	25	18469	4811	63465717
Asthenia	48.03	25.31	26	18468	383578	63086950
Asphyxia	47.93	25.31	27	18467	6154	63464374
Systemic lupus erythematosus	46.06	25.31	4	18490	208914	63261614
Sopor	45.03	25.31	43	18451	22121	63448407
Anaemia	44.51	25.31	15	18479	293415	63177113
Liver injury	44.23	25.31	70	18424	60450	63410078
Infection	44.07	25.31	7	18487	229166	63241362
Electrocardiogram QT prolonged	43.71	25.31	69	18425	59461	63411067
Drug hypersensitivity	41.98	25.31	19	18475	310668	63159860
Substance use disorder	41.17	25.31	10	18484	197	63470331
Product dose omission issue	41.12	25.31	9	18485	234304	63236224
Urinary tract infection	41.07	25.31	13	18481	264671	63205857
Victim of chemical submission	40.35	25.31	12	18482	520	63470008
Amnesia	40.21	25.31	64	18430	55521	63415007
Back pain	39.20	25.31	14	18480	264131	63206397
Sinusitis	39.18	25.31	9	18485	226644	63243884
Metabolic acidosis	38.41	25.31	56	18438	45013	63425515
Cough	37.87	25.31	19	18475	292724	63177804
Hepatic failure	37.44	25.31	49	18445	35607	63434921
Therapeutic product effect decreased	36.91	25.31	6	18488	193181	63277347
Weight increased	36.73	25.31	15	18479	260777	63209751
Wound	36.32	25.31	3	18491	163260	63307268
Treatment failure	36.25	25.31	7	18487	199036	63271492
Nausea	36.18	25.31	128	18366	854343	62616185
Electrocardiogram QRS complex prolonged	35.69	25.31	22	18472	5916	63464612
Protein C increased	35.57	25.31	8	18486	111	63470417
Hepatic encephalopathy	35.29	25.31	28	18466	11254	63459274
Homicide	35.02	25.31	10	18484	375	63470153
Discomfort	34.81	25.31	4	18490	167370	63303158
Neutropenia	34.43	25.31	5	18489	175000	63295528
Abnormal behaviour	33.35	25.31	36	18458	21390	63449138
Musculoskeletal stiffness	32.57	25.31	7	18487	184611	63285917
Sinus tachycardia	31.34	25.31	37	18457	24231	63446297
Substance dependence	31.28	25.31	8	18486	196	63470332
Constipation	29.99	25.31	14	18480	224929	63245599
Malaise	29.81	25.31	47	18447	415907	63054621
Induced abortion failed	29.61	25.31	8	18486	244	63470284
Ventricular tachycardia	28.38	25.31	32	18462	19947	63450581
Hypotension	28.23	25.31	155	18339	272449	63198079
Accidental death	28.11	25.31	13	18481	1963	63468565
Lower respiratory tract infection	27.92	25.31	3	18491	132304	63338224
Congenital umbilical hernia	27.89	25.31	8	18486	305	63470223
Road traffic accident	27.63	25.31	43	18451	36589	63433939
Shock	27.40	25.31	34	18460	23429	63447099
Encephalopathy	27.29	25.31	44	18450	38576	63431952
Disinhibition	26.86	25.31	10	18484	873	63469655
Haemoglobin decreased	26.73	25.31	5	18489	145480	63325048
Respiratory depression	26.71	25.31	26	18468	13689	63456839
Accidental overdose	25.98	25.31	33	18461	23276	63447252
Unresponsive to stimuli	25.93	25.31	40	18454	33776	63436752

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	5847.59	27.07	2215	19946	96881	34837889
Completed suicide	4145.62	27.07	1729	20432	96439	34838331
Toxicity to various agents	3779.12	27.07	2020	20141	198342	34736428
Cardio-respiratory arrest	879.75	27.07	504	21657	54769	34880001
Intentional overdose	830.86	27.07	448	21713	43226	34891544
Overdose	661.32	27.07	509	21652	90550	34844220
Alcohol abuse	578.77	27.07	184	21977	4506	34930264
Intentional product misuse	556.51	27.07	351	21810	45260	34889510
Alcohol interaction	538.47	27.07	156	22005	2757	34932013
Suicide attempt	494.58	27.07	308	21853	38808	34895962
Suspected suicide	400.99	27.07	140	22021	4608	34930162
Drug dependence	376.69	27.07	218	21943	23999	34910771
Alcohol poisoning	350.38	27.07	118	22043	3475	34931295
Substance abuse	306.17	27.07	131	22030	7510	34927260
Coma	264.08	27.07	224	21937	45454	34889316
Exposure to toxic agent	223.22	27.07	85	22076	3590	34931180
Asphyxia	218.43	27.07	100	22061	6735	34928035
Respiratory depression	217.90	27.07	133	22028	16112	34918658
Aggression	206.74	27.07	182	21979	38782	34895988
Poisoning deliberate	202.30	27.07	99	22062	7745	34927025
Respiratory arrest	196.68	27.07	154	22007	27889	34906881
Alcohol use	178.17	27.07	70	22091	3218	34931552
Diarrhoea	142.84	27.07	36	22125	389876	34544894
Drug ineffective	133.18	27.07	62	22099	456689	34478081
Pneumonia	126.15	27.07	37	22124	362590	34572180
Poisoning	124.06	27.07	84	22077	12142	34922628
Death	120.45	27.07	534	21627	397515	34537255
Cardiac arrest	118.76	27.07	216	21945	95943	34838827
Anaemia	117.03	27.07	8	22153	233327	34701443
Blood alcohol increased	116.98	27.07	36	22125	787	34933983
Incorrect route of product administration	113.82	27.07	86	22075	14759	34920011
Pyrexia	112.13	27.07	36	22125	332977	34601793
Substance use disorder	106.19	27.07	33	22128	746	34934024
Fatigue	103.80	27.07	53	22108	370600	34564170
Drug use disorder	102.40	27.07	51	22110	4140	34930630
Intentional product use issue	101.46	27.07	155	22006	59661	34875109
Miosis	93.14	27.07	64	22097	9471	34925299
Dyspnoea	92.60	27.07	63	22098	376719	34558051
Suicidal ideation	91.18	27.07	120	22041	40268	34894502
Depressed level of consciousness	88.64	27.07	122	22039	42719	34892051
Rash	88.57	27.07	17	22144	222735	34712035
Drug withdrawal syndrome	88.22	27.07	84	22077	19750	34915020
Intentional self-injury	86.63	27.07	71	22090	13700	34921070
Prescription drug used without a prescription	83.18	27.07	36	22125	2118	34932652
Agitation	82.58	27.07	138	22023	57261	34877509
Off label use	80.24	27.07	89	22072	419435	34515335
Neutropenia	79.64	27.07	5	22156	156773	34777997
Alcohol withdrawal syndrome	74.79	27.07	30	22131	1456	34933314
Cough	72.78	27.07	6	22155	150134	34784636
Mydriasis	71.68	27.07	49	22112	7188	34927582
Sopor	70.99	27.07	60	22101	12076	34922694
Drug interaction	65.58	27.07	300	21861	225646	34709124
Sepsis	63.49	27.07	14	22147	166547	34768223
Accidental death	63.31	27.07	31	22130	2425	34932345
Tachycardia	62.10	27.07	154	22007	84618	34850152
Medication error	60.85	27.07	78	22083	25487	34909283
Arthralgia	59.59	27.07	17	22144	170024	34764746
Condition aggravated	59.07	27.07	24	22137	192172	34742598
Pain	59.05	27.07	28	22133	204647	34730123
Alcoholism	57.79	27.07	31	22130	2934	34931836
Constipation	57.58	27.07	9	22152	136973	34797797
Platelet count decreased	54.78	27.07	6	22155	119711	34815059
Nausea	54.66	27.07	82	22079	339826	34594944
Road traffic accident	54.27	27.07	61	22100	17389	34917381
Loss of consciousness	54.15	27.07	144	22017	82523	34852247
Pain in extremity	53.88	27.07	8	22153	126505	34808265
Alcohol intolerance	52.93	27.07	17	22144	429	34934341
Drug screen positive	52.11	27.07	32	22129	3911	34930859
Withdrawal syndrome	52.08	27.07	51	22110	12404	34922366
Asthenia	51.33	27.07	48	22113	245203	34689567
Amnesia	50.98	27.07	73	22088	26490	34908280
Haemoglobin decreased	48.40	27.07	9	22152	120763	34814007
Pancytopenia	48.40	27.07	3	22158	95154	34839616
Decreased appetite	46.10	27.07	24	22137	166368	34768402
Ex-drug abuser	45.84	27.07	12	22149	142	34934628
Infection	45.84	27.07	3	22158	90912	34843858
Pruritus	44.80	27.07	17	22144	141964	34792806
Product dose omission issue	43.74	27.07	11	22150	119700	34815070
Somnolence	42.71	27.07	161	22000	110955	34823815
Metabolic acidosis	42.69	27.07	89	22072	43591	34891179
Weight decreased	42.46	27.07	30	22131	176271	34758499
Back pain	41.14	27.07	13	22148	121776	34812994
General physical health deterioration	41.06	27.07	15	22146	128254	34806516
Oedema peripheral	38.37	27.07	14	22147	119798	34814972
Hepatic fibrosis	38.23	27.07	28	22133	4579	34930191
Pulmonary oedema	37.60	27.07	89	22072	47440	34887330
Drug abuser	37.34	27.07	26	22135	3928	34930842
Opiates positive	37.30	27.07	14	22147	567	34934203
Peripheral swelling	37.22	27.07	3	22158	76538	34858232
Impaired driving ability	36.41	27.07	22	22139	2611	34932159
Cerebrovascular accident	34.66	27.07	6	22155	84805	34849965
Urinary tract infection	34.25	27.07	6	22155	84075	34850695
Dysarthria	34.13	27.07	71	22090	34711	34900059
Homicide	33.85	27.07	15	22146	934	34933836
Cardiac failure congestive	33.79	27.07	6	22155	83264	34851506
Neuropathy peripheral	33.79	27.07	6	22155	83257	34851513
Foetal alcohol syndrome	32.35	27.07	9	22152	136	34934634
Atrial fibrillation	31.94	27.07	19	22142	122374	34812396
Septic shock	31.85	27.07	4	22157	71830	34862940
Physical assault	31.16	27.07	15	22146	1130	34933640
Brain oedema	31.06	27.07	41	22120	13780	34920990
Thrombocytopenia	31.00	27.07	32	22129	156215	34778555
Abdominal pain	30.81	27.07	35	22126	163583	34771187
Electrocardiogram repolarisation abnormality	29.91	27.07	14	22147	990	34933780
Pleural effusion	28.81	27.07	8	22153	81538	34853232
Blood ethanol	28.81	27.07	8	22153	120	34934650
Renal impairment	28.67	27.07	12	22149	94501	34840269
Cardiac failure	28.64	27.07	11	22150	91237	34843533
Myocardial infarction	28.61	27.07	21	22140	121064	34813706
COVID-19	28.56	27.07	7	22154	77543	34857227
Muscular weakness	28.00	27.07	6	22155	72891	34861879
Malaise	27.73	27.07	47	22114	185778	34748992
Dehydration	27.65	27.07	25	22136	129944	34804826
Dizziness	27.63	27.07	61	22100	218460	34716310
Myocardial fibrosis	27.57	27.07	14	22147	1183	34933587

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	10375.97	25.94	3927	32290	241840	79466331
Drug abuse	8027.78	25.94	2926	33291	159765	79548406
Toxicity to various agents	7674.64	25.94	3716	32501	417824	79290347
Cardio-respiratory arrest	2175.94	25.94	1034	35183	107476	79600695
Intentional overdose	1694.29	25.94	866	35351	105094	79603077
Overdose	1304.71	25.94	889	35328	183317	79524854
Alcohol interaction	906.45	25.94	244	35973	4630	79703541
Intentional product misuse	885.55	25.94	546	35671	94619	79613552
Suicide attempt	802.54	25.94	488	35729	82444	79625727
Suspected suicide	791.47	25.94	262	35955	10314	79697857
Alcohol abuse	593.06	25.94	179	36038	5184	79702987
Respiratory arrest	544.41	25.94	334	35883	57216	79650955
Alcohol poisoning	524.88	25.94	159	36058	4662	79703509
Death	520.85	25.94	924	35293	565590	79142581
Exposure to toxic agent	491.47	25.94	177	36040	8981	79699190
Coma	440.43	25.94	365	35852	100284	79607887
Drug dependence	430.44	25.94	254	35963	40515	79667656
Cardiac arrest	423.09	25.94	453	35764	171643	79536528
Alcohol use	342.68	25.94	115	36102	4716	79703455
Substance abuse	337.83	25.94	140	36077	10386	79697785
Drug ineffective	318.17	25.94	55	36162	1080858	78627313
Poisoning deliberate	302.94	25.94	155	36062	18673	79689498
Diarrhoea	239.43	25.94	54	36163	880435	78827736
Asphyxia	228.61	25.94	110	36107	11610	79696561
Aggression	216.83	25.94	182	36035	50776	79657395
Poisoning	204.53	25.94	133	36084	25139	79683032
Respiratory depression	198.47	25.94	135	36082	27495	79680676
Fatigue	194.67	25.94	90	36127	929637	78778534
Agitation	187.90	25.94	229	35988	99486	79608685
Pain	187.47	25.94	45	36172	703757	79004414
Blood alcohol increased	186.18	25.94	53	36164	1242	79706929
Arthralgia	181.72	25.94	23	36194	571780	79136391
Rash	172.75	25.94	28	36189	578330	79129841
Dyspnoea	165.76	25.94	92	36125	856933	78851238
Drug use disorder	165.10	25.94	80	36137	8571	79699600
Off label use	164.79	25.94	105	36112	907110	78801061
Mydriasis	158.02	25.94	99	36118	17544	79690627
Pneumonia	155.86	25.94	53	36164	660193	79047978
Pyrexia	154.23	25.94	58	36159	678651	79029520
Intentional self-injury	144.55	25.94	119	36098	32300	79675871
Somnolence	143.95	25.94	328	35889	238653	79469518
Substance use disorder	142.14	25.94	40	36177	898	79707273
Anaemia	138.65	25.94	19	36198	444996	79263175
Depressed level of consciousness	137.01	25.94	193	36024	96459	79611712
Condition aggravated	129.47	25.94	34	36183	501090	79207081
Incorrect route of product administration	128.80	25.94	115	36102	34814	79673357
Loss of consciousness	123.48	25.94	250	35967	167693	79540478
Pain in extremity	119.81	25.94	13	36204	364525	79343646
Nausea	117.88	25.94	158	36059	957038	78751133
Miosis	117.80	25.94	79	36138	15710	79692461
Pruritus	115.73	25.94	20	36197	394628	79313543
Suicidal ideation	101.64	25.94	148	36069	76192	79631979
Alcoholism	101.11	25.94	44	36173	3679	79704492
Headache	100.09	25.94	90	36127	653682	79054489
Drug interaction	99.28	25.94	412	35805	414771	79293400
Cough	98.33	25.94	23	36194	366766	79341405
Drug intolerance	96.16	25.94	6	36211	264113	79444058
Neutropenia	95.17	25.94	10	36207	287700	79420471
Peripheral swelling	92.81	25.94	8	36209	269609	79438562
Accidental death	92.01	25.94	43	36174	4248	79703923
Tachycardia	91.83	25.94	230	35987	177538	79530633
Infusion related reaction	91.05	25.94	3	36214	230234	79477937
Postmortem blood drug level abnormal	90.58	25.94	26	36191	628	79707543
Intentional product use issue	89.51	25.94	207	36010	151905	79556266
Nasopharyngitis	88.85	25.94	7	36210	253874	79454297
Asthenia	84.97	25.94	65	36152	511624	79196547
Sopor	84.59	25.94	89	36128	32921	79675250
Metabolic acidosis	83.44	25.94	141	36076	82388	79625783
Back pain	81.65	25.94	19	36198	304161	79404010
Prescription drug used without a prescription	81.65	25.94	39	36178	4046	79704125
Constipation	79.39	25.94	16	36201	283034	79425137
Alopecia	79.25	25.94	7	36210	231348	79476823
Urinary tract infection	78.08	25.94	15	36202	274497	79433674
Hypersensitivity	77.46	25.94	13	36204	262226	79445945
Infection	75.96	25.94	10	36207	241702	79466469
Alcohol withdrawal syndrome	75.68	25.94	30	36187	1981	79706190
Abdominal discomfort	75.01	25.94	12	36205	250715	79457456
Weight decreased	74.60	25.94	34	36183	355164	79353007
Product dose omission issue	71.51	25.94	13	36204	247524	79460647
Weight increased	71.20	25.94	19	36198	277367	79430804
Electrocardiogram QRS complex prolonged	70.88	25.94	50	36167	10783	79697388
Malaise	70.71	25.94	71	36146	489798	79218373
Drug withdrawal syndrome	70.68	25.94	83	36134	34635	79673536
Swelling	70.46	25.94	8	36209	216703	79491468
Decreased appetite	68.52	25.94	35	36182	342383	79365788
White blood cell count decreased	66.41	25.94	5	36212	188283	79519888
Pulmonary oedema	65.53	25.94	132	36085	88122	79620049
Sepsis	64.49	25.94	21	36196	269407	79438764
Haemoglobin decreased	63.44	25.94	12	36205	222107	79486064
Chemical submission	63.23	25.94	17	36200	320	79707851
General physical health deterioration	63.21	25.94	23	36194	275215	79432956
Seizure	62.25	25.94	208	36009	188626	79519545
Drug hypersensitivity	62.15	25.94	29	36188	298887	79409284
Opiates positive	59.89	25.94	21	36196	983	79707188
Sinusitis	59.28	25.94	9	36208	195492	79512679
Musculoskeletal stiffness	58.05	25.94	6	36211	175002	79533169
Medication error	57.45	25.94	108	36109	68534	79639637
Drug abuser	57.02	25.94	35	36182	5978	79702193
Pancytopenia	56.79	25.94	5	36212	165740	79542431
Drug screen positive	56.75	25.94	35	36182	6028	79702143
Platelet count decreased	56.70	25.94	10	36207	194654	79513517
Homicide	56.47	25.94	21	36196	1165	79707006
Therapeutic product effect decreased	55.99	25.94	5	36212	163858	79544313
Urticaria	55.08	25.94	9	36208	185192	79522979
Dizziness	53.07	25.94	99	36118	526342	79181829
Therapeutic product effect incomplete	52.19	25.94	3	36214	141642	79566529
Stomatitis	51.45	25.94	4	36213	146753	79561418
Victim of sexual abuse	51.33	25.94	16	36201	516	79707655
Withdrawal syndrome	51.04	25.94	62	36155	26792	79681379
Shock	50.23	25.94	79	36138	43469	79664702
Amnesia	48.82	25.94	96	36121	62961	79645210
Abdominal pain	48.03	25.94	64	36153	389505	79318666
Blood ethanol	47.63	25.94	12	36205	173	79707998
Muscular weakness	47.37	25.94	8	36209	160721	79547450
Electrocardiogram QT prolonged	45.63	25.94	116	36101	90270	79617901
Amphetamines positive	44.71	25.94	13	36204	329	79707842
Postmortem blood drug level	44.49	25.94	13	36204	335	79707836
Product administration error	44.20	25.94	63	36154	31783	79676388
Asthma	43.86	25.94	5	36212	135090	79573081
Systemic lupus erythematosus	43.33	25.94	3	36214	121146	79587025
Road traffic accident	43.32	25.94	74	36143	43590	79664581
Blister	42.61	25.94	3	36214	119473	79588698
Cardiac failure congestive	42.16	25.94	7	36210	142395	79565776
COVID-19	41.98	25.94	10	36207	157664	79550507
Accidental overdose	41.82	25.94	69	36148	39512	79668659
Septic shock	41.27	25.94	4	36213	122797	79585374
Somnambulism	41.17	25.94	28	36189	5693	79702478
Cerebrovascular accident	41.04	25.94	10	36207	155282	79552889
Unresponsive to stimuli	40.87	25.94	83	36134	55705	79652466
Discomfort	39.92	25.94	5	36212	125612	79582559
Brain oedema	39.60	25.94	53	36164	25210	79682961
Blood ethanol increased	39.45	25.94	14	36203	679	79707492
Congestive hepatopathy	39.42	25.94	25	36192	4522	79703649
Thrombocytopenia	38.72	25.94	38	36179	265221	79442950
Sinus tachycardia	38.54	25.94	64	36153	36844	79671327
Victim of chemical submission	38.54	25.94	13	36204	541	79707630
Chest pain	38.34	25.94	43	36174	282261	79425910
Electrocardiogram ST segment elevation	37.78	25.94	31	36186	8366	79699805
Respiratory acidosis	37.61	25.94	35	36182	11165	79697006
Neuropathy peripheral	37.54	25.94	9	36208	141296	79566875
Hepatic fibrosis	37.29	25.94	29	36188	7251	79700920
Injection site pain	37.09	25.94	7	36210	129831	79578340
Influenza	36.99	25.94	7	36210	129599	79578572
Toxicologic test abnormal	36.69	25.94	16	36201	1344	79706827
Acute hepatic failure	36.64	25.94	56	36161	30057	79678114
Abnormal behaviour	36.49	25.94	62	36155	36359	79671812
Wheezing	36.21	25.94	5	36212	116659	79591512
Alcohol intolerance	36.20	25.94	12	36205	473	79707698
Dehydration	35.71	25.94	36	36181	248151	79460020
Loss of personal independence in daily activities	35.39	25.94	3	36214	102577	79605594
Abdominal distension	35.15	25.94	6	36211	119644	79588527
Fall	34.66	25.94	110	36107	487519	79220652
Liver injury	34.31	25.94	78	36139	56536	79651635
Erythema	33.74	25.94	31	36186	223259	79484912
Rhabdomyolysis	33.42	25.94	113	36104	103018	79605153
Bronchitis	33.40	25.94	9	36208	130635	79577536
Dysarthria	33.31	25.94	86	36131	67536	79640635
Oropharyngeal pain	33.21	25.94	5	36212	109348	79598823
Myocardial fibrosis	33.12	25.94	16	36201	1702	79706469
Cellulitis	33.09	25.94	5	36212	109055	79599116
Bradypnoea	32.95	25.94	25	36192	6027	79702144
Hypoaesthesia	32.04	25.94	21	36196	179331	79528840
Substance dependence	31.83	25.94	11	36206	493	79707678
Renal impairment	31.71	25.94	16	36201	157767	79550404
Euphoric mood	31.61	25.94	27	36190	7699	79700472
Physical assault	31.04	25.94	15	36202	1596	79706575
Therapy non-responder	31.03	25.94	3	36214	92302	79615869
Lower respiratory tract infection	31.02	25.94	10	36207	129210	79578961
C-reactive protein increased	30.95	25.94	10	36207	129017	79579154
Accidental poisoning	30.64	25.94	15	36202	1642	79706529
Oedema peripheral	30.50	25.94	42	36175	252246	79455925
Drug level increased	30.24	25.94	60	36157	39591	79668580
Gastrointestinal disorder	30.16	25.94	9	36208	122196	79585975
Dysphagia	30.13	25.94	9	36208	122127	79586044
Behaviour disorder	29.87	25.94	24	36193	6289	79701882
Leukopenia	29.83	25.94	8	36209	116505	79591666
Neutrophil count decreased	29.22	25.94	4	36213	93955	79614216
Osteoarthritis	28.93	25.94	3	36214	87306	79620865
Myocarditis	28.71	25.94	42	36175	21691	79686480
Hypothermia	28.67	25.94	43	36174	22703	79685468
Musculoskeletal pain	28.22	25.94	6	36211	102348	79605823
Upper respiratory tract infection	28.08	25.94	4	36213	91164	79617007
Delirium tremens	27.74	25.94	11	36206	727	79707444
Protein C increased	27.59	25.94	7	36210	104	79708067
Abdominal pain upper	27.32	25.94	37	36180	223782	79484389
Chills	26.98	25.94	20	36197	160214	79547957
Pulmonary embolism	26.93	25.94	23	36194	171631	79536540
Haematochezia	26.63	25.94	4	36213	87641	79620530
Impaired driving ability	26.50	25.94	21	36196	5394	79702777
Inappropriate schedule of product administration	26.19	25.94	14	36203	133614	79574557
Sudden death	26.18	25.94	41	36176	22470	79685701
Serotonin syndrome	26.14	25.94	61	36156	44966	79663205
Suicidal behaviour	26.04	25.94	17	36200	3230	79704941

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AE05	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Phenol and derivatives
MeSH PA	D000871	Anthelmintics
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D000977	Antiparasitic Agents
MeSH PA	D000980	Antiplatyhelmintic Agents
MeSH PA	D004202	Disinfectants
MeSH PA	D012556	Schistosomicides
CHEBI has role	CHEBI:33904	molluscicides
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:48219	disinfectants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Antiseptic preparation	indication	261276004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.85	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.93		DRUG MATRIX
Amine oxidase [flavin-containing] A	Enzyme	P21397	AOFA_HUMAN		IC50	5.74		DRUG MATRIX

External reference:

ID	Source
4019458	VUID
N0000147580	NUI
D03473	KEGG_DRUG
4018914	VANDF
4019458	VANDF
C0055463	UMLSCUI
CHEBI:34393	CHEBI
CHEMBL398440	ChEMBL_ID
DB11121	DRUGBANK_ID
2723	PUBCHEM_CID
492	INN_ID
C007027	MESH_SUPPLEMENTAL_RECORD_UI
0F32U78V2Q	UNII
20877	RXNORM
4423	MMSL
72857	MMSL
003140	NDDF
003202	NDDF
126151007	SNOMEDCT_US
398713003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Antibacterial Hand	HUMAN OTC DRUG LABEL	1	0404-4438	SOAP	6.10 g	TOPICAL	OTC monograph not final	11 sections
Antibacterial Hand	HUMAN OTC DRUG LABEL	1	0404-4438	SOAP	6.10 g	TOPICAL	OTC monograph not final	11 sections
Antibacterial	HUMAN OTC DRUG LABEL	1	0404-4441	LIQUID	6.05 g	TOPICAL	OTC monograph not final	11 sections
Antibacterial	HUMAN OTC DRUG LABEL	1	0404-4441	LIQUID	6.05 g	TOPICAL	OTC monograph not final	11 sections
Antimicrobial Hand Wash	HUMAN OTC DRUG LABEL	1	0404-5987	SOAP	6 mg	TOPICAL	OTC monograph not final	11 sections
Antimicrobial Hand Wash	HUMAN OTC DRUG LABEL	1	0404-5990	SOAP	6 mg	TOPICAL	OTC monograph not final	11 sections
Blistex Foille Medicated First Aid	HUMAN OTC DRUG LABEL	2	10157-9302	OINTMENT	0.10 g	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
PC511 ANTIMICROBIAL	HUMAN OTC DRUG LABEL	1	10685-511	SOAP	3 g	TOPICAL	OTC monograph not final	9 sections
PC529 ULTREX	HUMAN OTC DRUG LABEL	1	10685-529	SOAP	2.50 g	TOPICAL	OTC monograph not final	9 sections
PC537 E-2 BRUTE	HUMAN OTC DRUG LABEL	1	10685-537	SOAP	25 g	TOPICAL	OTC monograph not final	9 sections
PC557 PALPON	HUMAN OTC DRUG LABEL	1	10685-557	SOAP	2.50 g	TOPICAL	OTC monograph not final	9 sections
NAMICO ANTISEPTIC HAND CLEANER 557	HUMAN OTC DRUG LABEL	1	10685-978	SOAP	2.50 g	TOPICAL	OTC monograph not final	9 sections
Derma CIDOL 2000	HUMAN OTC DRUG LABEL	1	10802-8081	LIQUID	0.50 g	TOPICAL	OTC monograph not final	8 sections
Kindest Kare Hand Antimicrobial Handwash	HUMAN OTC DRUG LABEL	1	11084-036	SOAP	1 g	TOPICAL	OTC MONOGRAPH NOT FINAL	12 sections
PureBac Foam Wash	HUMAN OTC DRUG LABEL	1	11084-131	LIQUID	0.50 mL	TOPICAL	OTC monograph not final	18 sections
Refresh PureBac Foam	HUMAN OTC DRUG LABEL	1	11084-160	LIQUID	5 g	TOPICAL	OTC monograph not final	10 sections
Refresh PureBac Foam	HUMAN OTC DRUG LABEL	1	11084-160	LIQUID	5 g	TOPICAL	OTC monograph not final	10 sections
Acute-Kare Healthcare Personnel Handwash	HUMAN OTC DRUG LABEL	1	11084-800	SOAP	1 g	TOPICAL	OTC monograph not final	12 sections
Chloroxylenol	HUMAN OTC DRUG LABEL	1	11344-562	LIQUID	3.09 g	TOPICAL	OTC monograph not final	12 sections
chloroxylenol	HUMAN OTC DRUG LABEL	1	11344-710	LIQUID	3.09 mg	TOPICAL	OTC monograph not final	11 sections
chloroxylenol	HUMAN OTC DRUG LABEL	1	11344-710	LIQUID	3.09 mg	TOPICAL	OTC monograph not final	11 sections
antibacterial	HUMAN OTC DRUG LABEL	1	11344-713	LIQUID	3 mg	TOPICAL	OTC monograph not final	11 sections
antibacterial	HUMAN OTC DRUG LABEL	1	11344-713	LIQUID	3 mg	TOPICAL	OTC monograph not final	11 sections
FoamFresh Antibacterial Hand Wash	HUMAN OTC DRUG LABEL	1	11429-1005	LIQUID	2.50 mg	TOPICAL	OTC monograph not final	11 sections
FoamFresh Antibacterial Hand Wash	HUMAN OTC DRUG LABEL	1	11429-1005	LIQUID	2.50 mg	TOPICAL	OTC monograph not final	11 sections
Lemon Drop Gentle Antiseptic	HUMAN OTC DRUG LABEL	1	11429-1006	LIQUID	3 mg	TOPICAL	OTC monograph not final	11 sections
Lemon Drop Gentle Antiseptic	HUMAN OTC DRUG LABEL	1	11429-1006	LIQUID	3 mg	TOPICAL	OTC monograph not final	11 sections
Derma 1 Healthcare Hand Wash	HUMAN OTC DRUG LABEL	1	11429-1007	LIQUID	4 mg	TOPICAL	OTC monograph not final	11 sections
FoamFresh Healthcare Hand Wash	HUMAN OTC DRUG LABEL	1	11429-1008	LIQUID	7.50 mg	TOPICAL	OTC monograph not final	11 sections
Pink Antibacterial	HUMAN OTC DRUG LABEL	1	11429-1009	LIQUID	3 mg	TOPICAL	OTC monograph not final	11 sections