cefazedone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 3071 56187-47-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefazedone sodium
  • EMD30087
  • cefazedone
  • refosporen
  • Molecular weight: 548.43
  • Formula: C18H15Cl2N5O5S3
  • CLOGP: -0.65
  • LIPINSKI: 1
  • HAC: 10
  • HDO: 2
  • TPSA: 132.80
  • ALOGS: -4.85
  • ROTB: 7

Drug dosage:

DoseUnitRoute
3 g P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.13 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.95 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.91 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DB06 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
First-generation cephalosporins
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:36047 antibacterial drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.22 acidic
pKa2 1.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07237 KEGG_DRUG
63521-15-3 SECONDARY_CAS_RN
C0054999 UMLSCUI
CHEBI:131731 CHEBI
CHEMBL2107636 ChEMBL_ID
DB13778 DRUGBANK_ID
C021341 MESH_SUPPLEMENTAL_RECORD_UI
12203 IUPHAR_LIGAND_ID
4117 INN_ID
7Y86X0D799 UNII
71736 PUBCHEM_CID
010926 NDDF
010927 NDDF

Pharmaceutical products:

None