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benfluorex 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anorexics | 307 | 23602-78-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.45 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 3.33 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-selectivity-class | AKT3,AXL,EIF2AK3,GRK2,PDK4 | 5 | |||
| kinase-safety-class | ACVR2B,AKT1,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,TEK,TGFBR1 | 32 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A10BX06 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Other blood glucose lowering drugs, excl. insulins |
| MeSH PA | D000960 | Hypolipidemic Agents |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D001067 | Appetite Depressants |
| MeSH PA | D019440 | Anti-Obesity Agents |
| MeSH PA | D057847 | Lipid Regulating Agents |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
Related Drugs by ATC class:
A10BX Other blood glucose lowering drugs, excl. insulins 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Type 2 diabetes mellitus in obese | indication | 81531005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.57 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D07192 | KEGG_DRUG |
| 18880 | RXNORM |
| C0053105 | UMLSCUI |
| CHEBI:748820 | CHEBI |
| CHEMBL400599 | ChEMBL_ID |
| DB09022 | DRUGBANK_ID |
| C001584 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2318 | PUBCHEM_CID |
| 14184 | IUPHAR_LIGAND_ID |
| 3054 | INN_ID |
| 403FO0NQG3 | UNII |
| CHEMBL1412305 | ChEMBL_ID |
| 23642-66-2 | SECONDARY_CAS_RN |
| 004328 | NDDF |
| 004329 | NDDF |
| 719681008 | SNOMEDCT_US |
Pharmaceutical products:
None