canfosfamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives 3062 158382-37-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • canfosfamide hydrochloride
  • TLK286
  • TER286
  • canfosfamide
  • canfosfamide HCl
a glutathione-based glutathione S-transferase-activated cytotoxin; TLK-286 is the ((R)-(-))-isomer
  • Molecular weight: 787.46
  • Formula: C26H40Cl4N5O10PS
  • CLOGP: -0.20
  • LIPINSKI: 2
  • HAC: 15
  • HDO: 5
  • TPSA: 225.74
  • ALOGS: -4.31
  • ROTB: 25

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.46 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 28.50 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.28 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.97 acidic
pKa2 2.95 acidic
pKa3 12.25 acidic
pKa4 9.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03351 KEGG_DRUG
439943-59-6 SECONDARY_CAS_RN
C2827096 UMLSCUI
CHEBI:135883 CHEBI
CHEMBL2111086 ChEMBL_ID
CHEMBL2107319 ChEMBL_ID
DB04972 DRUGBANK_ID
C107479 MESH_SUPPLEMENTAL_RECORD_UI
8455 INN_ID
1RS284BFUI UNII
5312109 PUBCHEM_CID

Pharmaceutical products:

None