boric acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3035 10043-35-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • boric acid
  • boracic acid
  • trihydroxyborane
  • orthoboric acid
  • boron oxide hydroxide
A weakly acidic hydrate of boric oxide with mild antiseptic, antifungal, and antiviral properties. The exact mechanism of action of boric acid is unknown; generally cytotoxic to all cells. It is used in the treatment of yeast infections and cold sores
  • Molecular weight: 61.83
  • Formula: BH3O3
  • CLOGP: -1.75
  • LIPINSKI: None
  • HAC: 3
  • HDO: 3
  • TPSA: 60.69
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal toxicity 367.98 61.32 80 2396 7661 63478885
Pulmonary toxicity 346.63 61.32 79 2397 9376 63477170
Neoplasm malignant 260.81 61.32 80 2396 29781 63456765
Joint injury 257.31 61.32 79 2397 29493 63457053
Hepatotoxicity 243.84 61.32 80 2396 36961 63449585
C-reactive protein abnormal 211.48 61.32 76 2400 46020 63440526
Joint stiffness 207.08 61.32 73 2403 41796 63444750
Therapy non-responder 187.92 61.32 80 2396 75821 63410725
Musculoskeletal pain 172.91 61.32 80 2396 92197 63394349
Musculoskeletal stiffness 123.37 61.32 81 2395 184537 63302009
Treatment failure 117.82 61.32 81 2395 198962 63287584
Therapeutic product effect incomplete 108.96 61.32 65 2411 124991 63361555
Infection 105.31 61.32 80 2396 229093 63257453
Pain in extremity 87.17 61.32 84 2392 331402 63155144
Joint swelling 86.09 61.32 83 2393 327583 63158963
Arthropathy 72.19 61.32 65 2411 234727 63251819
Condition aggravated 66.88 61.32 80 2396 402137 63084409
Drug hypersensitivity 63.81 61.32 69 2407 310618 63175928

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal toxicity 194.57 55.70 43 1671 8066 79734608
Pulmonary toxicity 174.66 55.70 43 1671 12871 79729803
Joint injury 136.93 55.70 43 1671 31292 79711382
Neoplasm malignant 136.29 55.70 43 1671 31767 79710907
Joint stiffness 121.84 55.70 42 1672 40788 79701886
Hepatotoxicity 116.11 55.70 43 1671 51309 79691365
C-reactive protein abnormal 103.83 55.70 39 1675 48328 79694346
Therapy non-responder 91.75 55.70 43 1671 92262 79650412
Musculoskeletal pain 87.52 55.70 43 1671 102311 79640363
Treatment failure 69.51 55.70 44 1670 170442 79572232
Musculoskeletal stiffness 68.45 55.70 44 1670 174964 79567710

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S02AA03 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
MeSH PA D007306 Insecticides
MeSH PA D010575 Pesticides
CHEBI has role CHEBI:74783 adstringent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.99 acidic
pKa2 8.8 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
R57ZHV85D4 UNII
4018204 VUID
N0000146538 NUI
D01089 KEGG_DRUG
4018204 VANDF
C0006020 UMLSCUI
CHEBI:33118 CHEBI
BO3 PDB_CHEM_ID
CHEMBL42403 ChEMBL_ID
7628 PUBCHEM_CID
DB11326 DRUGBANK_ID
C032688 MESH_SUPPLEMENTAL_RECORD_UI
1700 RXNORM
4294 MMSL
4907 MMSL
003185 NDDF
21611007 SNOMEDCT_US
346349006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Gynetox HUMAN OTC DRUG LABEL 21 57520-0103 LIQUID 12 [hp_X] ORAL unapproved homeopathic 9 sections
See Clean-One Eye Drops HUMAN OTC DRUG LABEL 1 58354-105 LIQUID 21.64 mg OPHTHALMIC unapproved drug other 8 sections
Sha-lem HUMAN OTC DRUG LABEL 5 59862-100 OINTMENT 0.95 g TOPICAL unapproved drug other 10 sections
GYNOX-SOFT HUMAN OTC DRUG LABEL 1 66854-003 EMULSION 7 mg TOPICAL unapproved drug other 8 sections
ICEKING Skin Expert Anti-onychomycosis Gel HUMAN OTC DRUG LABEL 2 72501-072 GEL 0.20 g CUTANEOUS Export only 7 sections