atosiban indications/contra

Stem definitionDrug idCAS RN
3008 90779-69-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • atosiban acetate
  • atosiban
  • Antocin II
  • antocin
  • tractocil
  • tractocile
Atosiban is a synthetic peptide which is a competitive antagonist of human oxytocin at receptor level. In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence.
  • Molecular weight: 994.19
  • Formula: C43H67N11O12S2
  • CLOGP: -0.05
  • LIPINSKI: 3
  • HAC: 23
  • HDO: 11
  • TPSA: 365.67
  • ALOGS: -4.28
  • ROTB: 18

Drug dosage:

DoseUnitRoute
165 mg P

Approvals:

DateAgencyCompanyOrphan
Jan. 20, 2000 EMA Ferring Pharmaceuticals A/S

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC G02CX01 GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
OTHER GYNECOLOGICALS
Other gynecologicals
MeSH PA D006727 Hormone Antagonists
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists
MeSH PA D012102 Reproductive Control Agents
MeSH PA D015149 Tocolytic Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Prevention of Premature Labor indication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Oxytocin receptor GPCR ANTAGONIST Ki 7.96 CHEMBL DRUG LABEL
Vasopressin V2 receptor GPCR Ki 6.48 CHEMBL
Vasopressin V1a receptor GPCR Ki 9.82 CHEMBL
Vasopressin V1b receptor GPCR Ki 7.36 CHEMBL
Oxytocin receptor GPCR Ki 7.40 CHEMBL

External reference:

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IDSource
2213 IUPHAR_LIGAND_ID
C0164398 UMLSCUI
D03008 KEGG_DRUG
081D12SI0Z UNII
6392 INN_ID
914453-95-5 SECONDARY_CAS_RN
391792002 SNOMEDCT_US
008327 NDDF
326166008 SNOMEDCT_US
59639 RXNORM
CHEMBL382301 ChEMBL_ID
C047046 MESH_SUPPLEMENTAL_RECORD_UI
5311010 PUBCHEM_CID
CHEBI:135899 CHEBI

Pharmaceutical products:

None