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pyrantel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anthelminthics (undefined group) | 2999 | 15686-83-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Broad spectrum anthelmintic for livestock.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.75 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 7 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 55.08 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 10 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -0.321 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.330 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 40.644 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 8.222 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 63.370 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 84.150 | % | High | 1 |
| herg | hERG pIC50 | 4.993 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 3.027 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 8.375 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 69.170 | % | High | 1 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.575 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 85.114 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 68.880 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.615 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 67.330 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 125.026 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 90.080 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 72.550 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 887.156 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1974 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P02CC01 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTHELMINTICS ANTINEMATODAL AGENTS Tetrahydropyrimidine derivatives |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000969 | Antinematodal Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D009465 | Neuromuscular Agents |
| MeSH PA | D009467 | Neuromuscular Depolarizing Agents |
| CHEBI has role | CHEBI:35443 | anthelminthic drug |
| CHEBI has role | CHEBI:35444 | antinematodal drug |
Related Drugs by ATC class:
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ascariasis | indication | 2435008 | DOID:456 |
| Mixed intestinal infection due to Class Cestoda and/or Class Trematoda and/or Phylum Nemata | indication | 90679001 | |
| Enterobiasis | indication | 266162007 | |
| Infection by Moniliformis | off-label use | 2341000 | |
| Trichostrongyliasis | off-label use | 33710003 | DOID:1254 |
| Infection by Uncinaria | off-label use | 414490001 | |
| Necator Americanus Infection | off-label use | ||
| Ancylostoma Duodenale Infection | off-label use | ||
| Disease of liver | contraindication | 235856003 | DOID:409 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Removal and control of large roundworms, Toxocara canis | Indication |
| Dogs | Removal and control of large roundworms, Toxascaris leonin | Indication |
| Dogs | Removal and control of hookworms, Ancylostoma caninum | Indication |
| Dogs | Removal and control of hookworms, Uncinaria stenocephala | Indication |
| Horses | Removal of large strongyles, Strongylus vulgaris | Indication |
| Horses | Removal of large strongyles, Strongylus edentatus | Indication |
| Horses | Removal of large strongyles, Strongylus equinus | Indication |
| Horses | Removal of pinworms, Oxyuris equi | Indication |
| Horses | Removal of large roundworms, Parascaris | Indication |
| Swine | Removal and control of large roundworm, Ascaris suum | Indication |
| Swine | Prevention of migration and establishment of large roundworms (Ascaris suum) infections | Indication |
| Swine | Prevention of establishment of nodular worms (Oesophagostomum) infections | Indication |
| Swine | Removal and control of large roundworm, Ascaris suum | Indication |
| Swine | Removal and control of nodular worm, Oesophagostomum radiatum | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Banminth, Strongid | Zoetis Inc. | 1 |
| Banminth 48 | Phibro Animal Health Corp. | 1 |
| Strongid T | Zoetis Inc. | 1 |
| Purina Horse & Colt Wormer | Bimeda Animal Health Limited | 1 |
| Banminth / Mecadox | Phibro Animal Health Corp. | 2 |
| Nemex, Nemex-2, RFD Liquid Wormer | Zoetis Inc. | 1 |
| Dog Wormer Tablets | Farnam Companies Inc. | 1 |
| Tylan and Banminth | Phibro Animal Health Corp. | 2 |
| LINCOMIX and Banminth | Phibro Animal Health Corp. | 2 |
| Ban-A-Worm Py. Tartrate, Ban-A-Worm Pyrantel Tartrate Ton Pack | ADM Animal Nutrition | 1 |
| Banminth-P Paste, Strongid Paste | Zoetis Inc. | 1 |
| LINCOMIX and Banminth | Zoetis Inc. | 2 |
| Adams, D-Worm, Dog Wormer Chewable Tablets | Farnam Companies Inc. | 1 |
| Strongid 48 | Zoetis Inc. | 1 |
| Heartgard Plus | Boehringer lngelheim Animal Health USA Inc. | 2 |
| Drontal Plus, Drontal Plus Taste Tabs, Quad Dewormer | Elanco US Inc. | 3 |
| Drontal Tablets | Elanco US Inc. | 2 |
| Iverhart Max | Virbac AH Inc. | 3 |
| Sentry HC Worm X Plus | Virbac AH Inc. | 2 |
| IVERHART MAX Chew | Virbac AH Inc. | 3 |
| Simparica Trio | Zoetis Inc. | 3 |
| Liqui-Vict 2X | Happy Jack Inc. | 1 |
| PyrantelCare | Farnam Companies Inc. | 1 |
| Anthelban V | Elanco US Inc. | 1 |
| Pyrantel Pamoate Suspension, Pyrantel Pamoate Suspension-2.27mg, Pyrantel Pamoate Suspension-4.54mg | Cronus Pharma Specialities India Private Limited | 1 |
| Pyrantel Pamoate Chewable Tablets | Virbac AH Inc. | 1 |
| Continuex | Farnam Companies Inc. | 1 |
| Iverhart Plus Flavored Chewables | Virbac AH Inc. | 2 |
| Tri-Heart Plus Chewable Tablets | Heska Corp. | 2 |
| Pyrantel Pamoate Paste | Farnam Companies Inc. | 1 |
| Exodus Paste, Exodus Multi Dose | Bimeda Animal Health Limited | 1 |
| Primex 2-X, Primex Canine | First Priority Inc. | 1 |
| Primex Equine | First Priority Inc. | 1 |
| Primex | First Priority Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.98 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | Enzyme | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4019920 | VUID |
| N0000148005 | NUI |
| D00486 | KEGG_DRUG |
| 22204-24-6 | SECONDARY_CAS_RN |
| 4019104 | VANDF |
| 4019920 | VANDF |
| C0034235 | UMLSCUI |
| CHEBI:8654 | CHEBI |
| CHEMBL1626223 | ChEMBL_ID |
| DB11156 | DRUGBANK_ID |
| CHEMBL1599768 | ChEMBL_ID |
| D011715 | MESH_DESCRIPTOR_UI |
| 708857 | PUBCHEM_CID |
| 2228 | INN_ID |
| 4QIH0N49E7 | UNII |
| 2197593 | RXNORM |
| 4963 | MMSL |
| 5388 | MMSL |
| 5389 | MMSL |
| d01123 | MMSL |
| 002986 | NDDF |
| 004115 | NDDF |
| 25013003 | SNOMEDCT_US |
| 36068003 | SNOMEDCT_US |
| 387193008 | SNOMEDCT_US |
| 96117000 | SNOMEDCT_US |
| D011716 | MESH_DESCRIPTOR_UI |
| CHEMBL1585303 | ChEMBL_ID |
| 33401-94-4 | SECONDARY_CAS_RN |
| D011717 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Walgreens Pinworm Medicine | HUMAN OTC DRUG LABEL | 1 | 0363-0618 | SUSPENSION | 144 mg | ORAL | OTC Monograph Drug | 10 sections |
| Pinworm Medicine | HUMAN OTC DRUG LABEL | 1 | 10956-618 | SUSPENSION | 144 mg | ORAL | OTC monograph final | 10 sections |
| PinwormMedicine | HUMAN OTC DRUG LABEL | 1 | 10956-778 | SUSPENSION | 144 mg | ORAL | OTC Monograph Drug | 10 sections |
| pinworm treatment | HUMAN OTC DRUG LABEL | 1 | 46122-825 | SUSPENSION | 144 mg | ORAL | OTC Monograph Drug | 13 sections |
| Pyrantel Pamoate | HUMAN OTC DRUG LABEL | 1 | 51072-088 | SUSPENSION | 50 mg | ORAL | OTC Monograph Drug | 14 sections |
| PARASITOL | HUMAN OTC DRUG LABEL | 1 | 53145-101 | SUSPENSION | 144 mg | ORAL | OTC Monograph Drug | 9 sections |
| MebendamaXPinworm | HUMAN OTC DRUG LABEL | 1 | 55758-441 | TABLET | 180 mg | ORAL | OTC Monograph Drug | 11 sections |
| Pyrantel Pamoate | HUMAN OTC DRUG LABEL | 1 | 58988-1760 | TABLET | 180 mg | ORAL | OTC MONOGRAPH FINAL | 10 sections |
| Pyrantel Pamoate | HUMAN OTC DRUG LABEL | 1 | 58988-1770 | SUSPENSION | 144 mg | ORAL | OTC Monograph Drug | 11 sections |
| Pinworm Treatment | HUMAN OTC DRUG LABEL | 1 | 59779-538 | SUSPENSION | 144 mg | ORAL | OTC monograph final | 13 sections |
| Pyrantel Pamoate | HUMAN OTC DRUG LABEL | 1 | 62337-415 | SUSPENSION | 50 mg | ORAL | OTC Monograph Drug | 13 sections |
| PinwormMedicine | HUMAN OTC DRUG LABEL | 1 | 63187-586 | SUSPENSION | 144 mg | ORAL | OTC monograph final | 10 sections |
| Pronto Plus Pinworm Treatment | HUMAN OTC DRUG LABEL | 1 | 63736-240 | LIQUID | 5 mL | ORAL | OTC MONOGRAPH FINAL | 14 sections |
| pinworm treatment | HUMAN OTC DRUG LABEL | 1 | 69452-515 | SUSPENSION | 144 mg | ORAL | OTC Monograph Drug | 13 sections |
| VRMX 500 | HUMAN OTC DRUG LABEL | 1 | 69729-141 | TABLET | 180 mg | ORAL | OTC Monograph Drug | 13 sections |
| Lombrix | HUMAN OTC DRUG LABEL | 1 | 69729-807 | TABLET | 180 mg | ORAL | OTC Monograph Drug | 13 sections |
| CVS Pinworm Treatment | HUMAN OTC DRUG LABEL | 1 | 69842-618 | SUSPENSION | 144 mg | ORAL | OTC Monograph Drug | 10 sections |
| Parasitexx | HUMAN OTC DRUG LABEL | 1 | 70242-134 | SUSPENSION | 144 mg | ORAL | OTC monograph final | 12 sections |
| PinAway | HUMAN OTC DRUG LABEL | 1 | 70309-080 | SUSPENSION | 144 mg | ORAL | OTC monograph final | 13 sections |
| pinworm treatment | HUMAN OTC DRUG LABEL | 1 | 70677-1312 | SUSPENSION | 144 mg | ORAL | OTC Monograph Drug | 13 sections |
| PINRID | HUMAN OTC DRUG LABEL | 1 | 73581-111 | TABLET | 250 mg | ORAL | OTC Monograph Drug | 13 sections |
| PINRID | HUMAN OTC DRUG LABEL | 1 | 73581-112 | TABLET | 250 mg | ORAL | OTC Monograph Drug | 12 sections |
| PINRID | HUMAN OTC DRUG LABEL | 1 | 73581-113 | TABLET | 250 mg | ORAL | OTC Monograph Drug | 12 sections |
| DEWORMER FOR DOG | HUMAN OTC DRUG LABEL | 1 | 87276-262 | SUSPENSION | 4.54 mg | ORAL | OTC Monograph Drug | 8 sections |