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somatostatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
growth hormone derivatives	2997	38916-34-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: somatostatin aminopan growth hormone release-inhibiting factor somatotropin release-inhibiting hormone SRIF-14	A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal. Molecular weight: 1637.90 Formula: C76H104N18O19S2 CLOGP: -1.45 LIPINSKI: 3 HAC: 37 HDO: 22 TPSA: 613.23 ALOGS: -4.90 ROTB: 26

Molecule

Description

Molfile Inchi Smiles

Synonyms:

somatostatin
aminopan
growth hormone release-inhibiting factor
somatotropin release-inhibiting hormone
SRIF-14

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

Molecular weight: 1637.90
Formula: C76H104N18O19S2
CLOGP: -1.45
LIPINSKI: 3
HAC: 37
HDO: 22
TPSA: 613.23
ALOGS: -4.90
ROTB: 26

Drug dosage:

Dose	Unit	Route
6	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Administration site abscess	58.76	44.91	6	287	21	63488708
Administration site induration	58.12	44.91	6	287	24	63488705
Administration site discharge	57.20	44.91	6	287	29	63488700
Administration site odour	55.30	44.91	6	287	42	63488687
Injection site cyst	52.79	44.91	6	287	67	63488662
Administration site haemorrhage	50.22	44.91	6	287	106	63488623
Buttock injury	45.40	44.91	6	287	244	63488485

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastric varices	52.32	51.30	8	256	564	34956103

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Administration site abscess	56.16	33.51	6	558	21	79743803
Administration site discharge	54.61	33.51	6	558	29	79743795
Administration site induration	54.11	33.51	6	558	32	79743792
Administration site odour	53.37	33.51	6	558	37	79743787
Gastric varices	50.71	33.51	8	556	733	79743091
Administration site haemorrhage	50.03	33.51	6	558	69	79743755
Injection site cyst	48.43	33.51	6	558	92	79743732
Buttock injury	44.95	33.51	6	558	169	79743655
Injection site paraesthesia	37.47	33.51	6	558	603	79743221

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FDA Adverse Event Reporting System (Pediatric)

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Pharmacologic Action:

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Source	Code	Description
ATC	H01CB01	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES HYPOTHALAMIC HORMONES Somatostatin and analogues
MeSH PA	D006728	Hormones

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Drug Use | Suggest Off label Use Form| |View source of the data|

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🐶 Veterinary Drug Use

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🐶 Veterinary products

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Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.02	acidic
pKa10	13.88	acidic
pKa11	11.11	Basic
pKa12	10.51	Basic
pKa13	8.46	Basic
pKa2	12.17	acidic
pKa3	12.57	acidic
pKa4	12.85	acidic
pKa5	13.02	acidic
pKa6	13.2	acidic

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Orange Book patent data (new drug applications)

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Orange Book exclusivity data (new drug applications)

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Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Somatostatin receptor type 2	GPCR	P30874	SSR2_HUMAN	AGONIST	Ki	10.46	CHEMBL	IUPHAR
Somatostatin receptor type 3	GPCR	P32745	SSR3_HUMAN	AGONIST	Ki	10	CHEMBL	IUPHAR
Somatostatin receptor type 5	GPCR	P35346	SSR5_HUMAN	AGONIST	Ki	9.85	CHEMBL	IUPHAR
Somatostatin receptor type 4	GPCR	P31391	SSR4_HUMAN	AGONIST	Ki	9.23	CHEMBL	IUPHAR
Somatostatin receptor type 1	GPCR	P30872	SSR1_HUMAN	AGONIST	Ki	9.54	CHEMBL	IUPHAR
Somatostatin receptor	GPCR		SSR5_MOUSE SSR1_MOUSE SSR2_MOUSE SSR3_MOUSE SSR4_MOUSE		IC50	5.89	CHEMBL
Mu-type opioid receptor	GPCR		OPRM_RAT		IC50	8.22	CHEMBL
Somatostatin receptor	GPCR		SSR1_RAT SSR2_RAT SSR3_RAT SSR4_RAT SSR5_RAT		IC50	9.70	CHEMBL
Delta-type opioid receptor	GPCR		OPRD_RAT		IC50	5.70	CHEMBL
Somatostatin receptor type 2	GPCR		SSR2_MOUSE		IC50	9.55	CHEMBL

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External reference:

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ID	Source
005072	NDDF
16129706	PUBCHEM_CID
2019	IUPHAR_LIGAND_ID
4311	INN_ID
49722008	SNOMEDCT_US
57819002	SNOMEDCT_US
6E20216Q0L	UNII
9939	RXNORM
C0037659	UMLSCUI
CHEBI:64628	CHEBI

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Pharmaceutical products:

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