benactyzine indications/contra

Stem definitionDrug idCAS RN
298 302-40-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benactyzine
  • benactyzin
  • diethylaminoethyl benzilate
  • diazil
  • benactyzine hydrochloride
  • benactyzine HCl
A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior.
  • Molecular weight: 327.42
  • Formula: C20H25NO3
  • CLOGP: 3.76
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.77
  • ALOGS: -3.24
  • ROTB: 9

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000928 Antidepressive Agents
MeSH PA D001337 Autonomic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.56 acidic
pKa2 8.42 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
4019626 VUID
N0000147719 NUI
C0004962 UMLSCUI
D07498 KEGG_DRUG
26R628272Q UNII
57-37-4 SECONDARY_CAS_RN
496 INN_ID
CHEMBL70352 ChEMBL_ID
4019626 VANDF
N0000147719 NDFRT
N0000005789 NDFRT
1361 RXNORM
52275001 SNOMEDCT_US
004604 NDDF
9330 PUBCHEM_CID
DB09023 DRUGBANK_ID
D001535 MESH_DESCRIPTOR_UI
CHEBI:94775 CHEBI

Pharmaceutical products:

None