belotecan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antineoplastics, topoisomerase I inhibitors | 296 | 256411-32-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 10, 2003 | Korean Food and Drug Administration (KFDA) | Chong Kun Dang |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01CE04 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Topoisomerase 1 (TOP1) inhibitors |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D059004 | Topoisomerase I Inhibitors |
| MeSH PA | D059003 | Topoisomerase Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
| Malignant tumor of ovary | indication | 363443007 | DOID:2394 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.72 | acidic |
| pKa2 | 10.12 | Basic |
| pKa3 | 2.85 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| DNA topoisomerase 1 | Enzyme | INHIBITOR | IC50 | 6.56 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| C0762737 | UMLSCUI |
| CHEBI:135702 | CHEBI |
| D03225 | KEGG_DRUG |
| CHEMBL2111084 | ChEMBL_ID |
| DB12459 | DRUGBANK_ID |
| C116963 | MESH_SUPPLEMENTAL_RECORD_UI |
| 8483 | INN_ID |
| 213819-48-8 | SECONDARY_CAS_RN |
| 27Z82M2G1N | UNII |
| 6456014 | PUBCHEM_CID |
| CHEMBL2107315 | ChEMBL_ID |
Pharmaceutical products:
None