DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
belotecan 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antineoplastics, topoisomerase I inhibitors
296
256411-32-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
belotecan
camtobell
belotecan hydrochloride
CKD602
CKD-602
Molecular weight: 433.51
Formula: C25H27N3O4
CLOGP: 1.47
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 91.76
ALOGS: -3.75
ROTB: 5
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
Dec. 10, 2003
Korean Food and Drug Administration (KFDA)
Chong Kun Dang
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
L01CE04
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Topoisomerase 1 (TOP1) inhibitors
MeSH PA
D000970
Antineoplastic Agents
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D059004
Topoisomerase I Inhibitors
MeSH PA
D059003
Topoisomerase Inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Non-small cell lung cancer
indication
254637007
DOID:3908
Malignant tumor of ovary
indication
363443007
DOID:2394
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
10.72
acidic
pKa2
10.12
Basic
pKa3
2.85
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
DNA topoisomerase 1
Enzyme
P11387
TOP1_HUMAN
INHIBITOR
IC50
6.56
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
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External reference:
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entries
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ID
Source
213819-48-8
SECONDARY_CAS_RN
27Z82M2G1N
UNII
6456014
PUBCHEM_CID
8483
INN_ID
C0762737
UMLSCUI
C116963
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135702
CHEBI
CHEMBL2107315
ChEMBL_ID
CHEMBL2111084
ChEMBL_ID
D03225
KEGG_DRUG
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Pharmaceutical products:
None
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belotecan