belotecan indications/contra

Stem definitionDrug idCAS RN
antineoplastics, topoisomerase I inhibitors 296 256411-32-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • belotecan
  • camtobell
  • belotecan hydrochloride
  • CKD602
  • CKD-602
  • Molecular weight: 433.51
  • Formula: C25H27N3O4
  • CLOGP: 0.87
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 91.76
  • ALOGS: -3.75
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 10, 2003 Korean Food and Drug Administration (KFDA) Chong Kun Dang

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059004 Topoisomerase I Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Non-small cell lung cancer indication 254637007 DOID:3908
Malignant tumor of ovary indication 363443007 DOID:2394

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.72 acidic
pKa2 10.12 Basic
pKa3 2.85 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA topoisomerase 1 Enzyme INHIBITOR IC50 6.56 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

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IDSource
01DZ4127G7 UNII
213819-48-8 SECONDARY_CAS_RN
8483 INN_ID
D03225 KEGG_DRUG
6456014 PUBCHEM_CID
C116963 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2107315 ChEMBL_ID
CHEMBL2111084 ChEMBL_ID
DB12459 DRUGBANK_ID
CHEBI:135702 CHEBI

Pharmaceutical products:

None