gonadorelin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
pituitary hormone-release stimulating peptides	2958	33515-09-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: gonadorelin Luteinizing hormone-releasing factor (swine) hypocrine fertagyl gonadorelin hydrochloride gonadorelin acetate gonadorelin HCl gonadorelin diacetate tetrahydrate	A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND. Molecular weight: 1182.31 Formula: C55H75N17O13 CLOGP: -6.31 LIPINSKI: 3 HAC: 30 HDO: 17 TPSA: 472.13 ALOGS: -4.33 ROTB: 31 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

gonadorelin
Luteinizing hormone-releasing factor (swine)
hypocrine
fertagyl
gonadorelin hydrochloride
gonadorelin acetate
gonadorelin HCl
gonadorelin diacetate tetrahydrate

A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.

Molecular weight: 1182.31
Formula: C55H75N17O13
CLOGP: -6.31
LIPINSKI: 3
HAC: 30
HDO: 17
TPSA: 472.13
ALOGS: -4.33
ROTB: 31

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 30, 1982	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Metastases to bone	122.94	56.44	31	642	20988	63467361
Neutropenia	114.97	56.44	49	624	174956	63313393
Ovarian hyperstimulation syndrome	103.40	56.44	20	653	3994	63484355

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Recalled product administered	68.19	37.15	10	255	531	34956135

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Metastases to bone	101.31	43.22	27	754	24400	79719207
Ovarian hyperstimulation syndrome	94.63	43.22	18	763	3553	79740054
Neutropenia	86.50	43.22	46	735	287664	79455943
Carcinoembryonic antigen increased	45.35	43.22	9	772	2200	79741407
Meningeal disorder	44.74	43.22	7	774	436	79743171

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	H01CA01	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES HYPOTHALAMIC HORMONES Gonadotropin-releasing hormones
ATC	V04CM01	VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for fertility disturbances
CHEBI has role	CHEBI:63533	gonadotropin releasing hormone agonists

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Amenorrhea	indication	14302001	DOID:13938
Diagnostic Test for Gonadotropin Deficiency	indication

🐶 Veterinary Drug Use

Species	Use	Relation
Cattle	Reproductive synchrony programs	Indication
Cattle	Ovarian cysts	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
CYSTORELIN	Boehringer lngelheim Animal Health USA Inc.	1
Factrel, Factrel Injection	Zoetis Inc.	1
Fertelin, OvaCyst	Bimeda Animal Health Limited	1
FERTAGYL	Intervet Inc.	1
Gonabreed	Parnell Technologies Pty. Ltd.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.65	acidic
pKa2	11.9	acidic
pKa3	12.71	acidic
pKa4	12.88	acidic
pKa5	13.24	acidic
pKa6	13.32	acidic
pKa7	13.61	acidic
pKa8	13.97	acidic
pKa9	10.75	Basic
pKa10	6.69	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Gonadotropin-releasing hormone receptor	GPCR	P30968	GNRHR_HUMAN	AGONIST	IC50	8	CHEMBL	CHEMBL
Gonadotropin-releasing hormone receptor	GPCR		GNRHR_RAT		IC50	8.70	CHEMBL
Lutropin-choriogonadotropic hormone receptor	GPCR		LSHR_RAT		Ki	8.90	CHEMBL

External reference:

ID	Source
4019767	VUID
N0000147858	NUI
D00988	KEGG_DRUG
51952-41-1	SECONDARY_CAS_RN
4018487	VANDF
4018488	VANDF
4019767	VANDF
C0023610	UMLSCUI
CHEBI:5520	CHEBI
CHEMBL1007	ChEMBL_ID
CHEMBL1200511	ChEMBL_ID
CHEMBL1200516	ChEMBL_ID
DB00644	DRUGBANK_ID
3627	INN_ID
52699-48-6	SECONDARY_CAS_RN
9O7312W37G	UNII
638793	PUBCHEM_CID
1298838	RXNORM
4796	MMSL
4797	MMSL
d00573	MMSL
002108	NDDF
002109	NDDF
004782	NDDF
008305	NDDF
008306	NDDF
325995009	SNOMEDCT_US
397197007	SNOMEDCT_US
412193007	SNOMEDCT_US
49869009	SNOMEDCT_US
75969007	SNOMEDCT_US
96365009	SNOMEDCT_US
D007987	MESH_DESCRIPTOR_UI

Pharmaceutical products:

None