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eledoisin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2955	69-25-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: eledoisin eledone peptide ELD 950 ELD-950 eledoisin trifluoroacetate	A peptide extracted from the posterior salivary glands of certain small octopi (Eledone spp., Mollusca), or obtained by synthesis. Its actions resemble those of SUBSTANCE P; it is a potent vasodilator and increases capillary permeability. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1364) Molecular weight: 1188.41 Formula: C54H85N13O15S CLOGP: -6.92 LIPINSKI: 3 HAC: 28 HDO: 14 TPSA: 437.95 ALOGS: -4.80 ROTB: 36

Molecule

Description

Molfile Inchi Smiles

Synonyms:

eledoisin
eledone peptide
ELD 950
ELD-950
eledoisin trifluoroacetate

A peptide extracted from the posterior salivary glands of certain small octopi (Eledone spp., Mollusca), or obtained by synthesis. Its actions resemble those of SUBSTANCE P; it is a potent vasodilator and increases capillary permeability. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1364)

Molecular weight: 1188.41
Formula: C54H85N13O15S
CLOGP: -6.92
LIPINSKI: 3
HAC: 28
HDO: 14
TPSA: 437.95
ALOGS: -4.80
ROTB: 36

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Sjögren's syndrome	indication	83901003	DOID:12894

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.79	acidic
pKa2	12.41	acidic
pKa3	12.75	acidic
pKa4	13.03	acidic
pKa5	13.35	acidic
pKa6	13.54	acidic
pKa7	13.89	acidic
pKa8	14.0	acidic
pKa9	10.81	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Substance-P receptor	GPCR	P25103	NK1R_HUMAN	AGONIST	IC50	8.60		IUPHAR
Neuromedin-K receptor	GPCR	P29371	NK3R_HUMAN		EC50	9.66		CHEMBL

External reference:

ID	Source
D07936	KEGG_DRUG
C0013877	UMLSCUI
CHEBI:135903	CHEBI
CHEMBL373569	ChEMBL_ID
D004600	MESH_DESCRIPTOR_UI
2086	IUPHAR_LIGAND_ID
3278	INN_ID
10129-92-7	SECONDARY_CAS_RN
OKY3285J18	UNII
10328936	PUBCHEM_CID

Pharmaceutical products:

None