befunolol indications/contra

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 295 39552-01-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bentos
  • befunolol
  • befunolol hydrochloride
  • befunolol HCl
synonym BFE 60 refers to HCl; RN given refers to parent cpd; structure
  • Molecular weight: 291.35
  • Formula: C16H21NO4
  • CLOGP: 1.80
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 71.70
  • ALOGS: -3.43
  • ROTB: 7

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC S01ED06 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Beta blocking agents1)
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

scroll-->
DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282
Open-angle glaucoma indication 84494001 DOID:1067

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

scroll-->
IDSource
D01512 KEGG_DRUG
418546MT3A UNII
4452 INN_ID
2309 PUBCHEM_CID
005239 NDDF
39543-79-8 SECONDARY_CAS_RN
CHEMBL153984 ChEMBL_ID
CHEBI:135212 CHEBI
C006034 MESH_SUPPLEMENTAL_RECORD_UI
DB09013 DRUGBANK_ID

Pharmaceutical products:

None