beclometasone dipropionate indications/contra

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 294 5534-09-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rhinocort
  • beclometasone dipropionate
  • beclomethasone dipropionate
  • beclomethasone dipropionate monohydrate
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.
  • Molecular weight: 521.05
  • Formula: C28H37ClO7
  • CLOGP: 4.26
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -5.40
  • ROTB: 8

Drug dosage:

DoseUnitRoute
0.40 mg N
0.80 mg Inhal.aerosol
0.80 mg Inhal.powder
1.50 mg Inhal.solution

Approvals:

DateAgencyCompanyOrphan
May 12, 1976 FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nasal discomfort 278.07 35.48 45 860 839 3384115
Asthma 192.14 35.48 52 853 12350 3372604
Epistaxis 97.71 35.48 32 873 14419 3370535
Drug ineffective 87.26 35.48 55 850 116035 3268919
Sneezing 83.71 35.48 20 885 2838 3382116
Exposure during pregnancy 77.55 35.48 32 873 27531 3357423
Cough 69.28 35.48 33 872 39825 3345129
Device malfunction 65.39 35.48 18 887 4466 3380488
Nasal septum perforation 60.69 35.48 10 895 205 3384749
Dyspnoea 53.64 35.48 39 866 102895 3282059
Drug effect decreased 44.39 35.48 17 888 11952 3373002
Anosmia 44.18 35.48 10 895 1115 3383839
Drug administered to patient of inappropriate age 43.12 35.48 10 895 1242 3383712
Burning sensation 41.65 35.48 15 890 8889 3376065
Aggression 41.61 35.48 16 889 11369 3373585
Dysphonia 40.26 35.48 14 891 7490 3377464
Abnormal behaviour 39.91 35.48 15 890 10013 3374941
Nasal septum ulceration 37.62 35.48 5 900 20 3384934
Aortic dissection 36.84 35.48 8 897 737 3384217

Pharmacologic Action:

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SourceCodeDescription
ATC A07EA07 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC D07AC15 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
ATC D07CC04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, potent, combinations with antibiotics
ATC R01AD01 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03AK08 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK13 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AL09 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combinations with anticholinergics incl. triple combinations with corticosteroids
ATC R03BA01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
FDA EPC N0000175576 Corticosteroid
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
MeSH PA D000305 Adrenal Cortex Hormones
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:49167 anti-asthmatic drug
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:35472 anti-inflammatory drug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Nasal polyp indication 52756005
Allergic rhinitis indication 61582004
Rhinitis indication 70076002 DOID:4483
Asthma indication 195967001 DOID:2841
Asthma management indication 406162001
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Inactive tuberculosis contraindication 11999007
Epistaxis contraindication 12441001
Measles contraindication 14189004 DOID:8622
Disease caused by parasite contraindication 17322007
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Perforation of nasal septum contraindication 80142000
Bacterial infectious disease contraindication 87628006 DOID:104
Mycobacteriosis contraindication 88415009
Operation on nose contraindication 88733004
Bilateral cataracts contraindication 95722004
Ophthalmic herpes simplex contraindication 186542001
Disease of liver contraindication 235856003 DOID:409
Varicella-zoster virus infection contraindication 309465005
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Exposure to varicella contraindication 444453009
Nasal Trauma contraindication
Nasal Candidiasis contraindication
Nasal Septal Ulcers contraindication
Untreated Fungal Infection contraindication
Uncontrolled Bacterial Infections contraindication
Severe chronic obstructive pulmonary disease off-label use 313299006

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.01 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 8.43 DRUG MATRIX CHEMBL
Matrix metalloproteinase-9 Enzyme IC50 5.70 CHEMBL
Interleukin-5 Cytokine IC50 4.57 CHEMBL
Glucocorticoid receptor Transcription factor IC50 8.54 CHEMBL
Interleukin-5 Unclassified IC50 4.58 CHEMBL
Progesterone receptor Transcription factor Ki 7.57 CHEMBL
Androgen receptor Transcription factor Ki 5.96 CHEMBL

External reference:

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IDSource
DB00394 DRUGBANK_ID
C0678163 UMLSCUI
7059 IUPHAR_LIGAND_ID
D00689 KEGG_DRUG
4H7L9AI22I UNII
77011-63-3 SECONDARY_CAS_RN
1348 RXNORM
116575004 SNOMEDCT_US
4249 MMSL
4018793 VANDF
71834 MMSL
N0000147096 NDFRT
N0000178887 NDFRT
002179 NDDF
CHEMBL1370 ChEMBL_ID
21700 PUBCHEM_CID
CHEMBL1586 ChEMBL_ID
CHEMBL1200500 ChEMBL_ID
2307 INN_ID
D001507 MESH_DESCRIPTOR_UI
CHEBI:3002 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
BECONASE HUMAN PRESCRIPTION DRUG LABEL 1 16590-030 SPRAY, SUSPENSION 42 ug NASAL NDA 13 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 16590-860 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 14 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 50090-1342 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 16 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 53002-1436 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 16 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 53002-1477 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 16 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 54868-5857 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 13 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 54868-5858 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 13 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 59310-202 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 16 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 59310-204 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 16 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-206 AEROSOL, METERED 40 ug NASAL NDA 18 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-210 AEROSOL, METERED 80 ug NASAL NDA 18 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-302 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 15 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-304 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 15 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 68788-7025 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 16 sections