barnidipine indications/contra

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 290 104713-75-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • barnidipine
  • mepirodipine
  • vasexten
  • mepirodipine hydrobromide
  • mepirodipine hydrochloride
  • Molecular weight: 491.54
  • Formula: C27H29N3O6
  • CLOGP: 5.15
  • LIPINSKI: 1
  • HAC: 9
  • HDO: 1
  • TPSA: 111.01
  • ALOGS: -5.09
  • ROTB: 9

Drug dosage:

DoseUnitRoute
10 mg O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C08CA12 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.17 Basic
pKa2 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER DRUG LABEL KEGG DRUG

External reference:

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IDSource
C0078703 UMLSCUI
D07494 KEGG_DRUG
2VBY96ASWJ UNII
6746 INN_ID
39879 RXNORM
698052006 SNOMEDCT_US
009143 NDDF
443869 PUBCHEM_CID
C050699 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2103761 ChEMBL_ID
DB09227 DRUGBANK_ID
CHEBI:135793 CHEBI

Pharmaceutical products:

None