barbital indications/contra

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 289 57-44-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • barbital sodium
  • sodium diethylbarbiturate
  • barbital
  • barbitone
  • diethylbarbitone
  • diethylbarbituric acid
  • diethylmalonylurea
  • ethylbarbital
  • veronal
A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression.
  • Molecular weight: 184.20
  • Formula: C8H12N2O3
  • CLOGP: 0.66
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.27
  • ALOGS: -1.76
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.50 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N05CA04 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Barbiturates, plain
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.31 acidic
pKa2 10.0 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
CHEBI:31252 CHEBI
4019012 VUID
N0000147286 NUI
C0004743 UMLSCUI
D01740 KEGG_DRUG
CHEMBL444 ChEMBL_ID
275L5M93QS UNII
380 INN_ID
144-02-5 SECONDARY_CAS_RN
4019012 VANDF
N0000006739 NDFRT
N0000147286 NDFRT
1325 RXNORM
111124009 SNOMEDCT_US
001404 NDDF
DB01483 DRUGBANK_ID
CHEMBL2105904 ChEMBL_ID
D001462 MESH_DESCRIPTOR_UI
2294 PUBCHEM_CID

Pharmaceutical products:

None