DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
zotepine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
tricyclic compounds
2875
26615-21-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
zoleptil
zotepine
lodopin
nipolept
Molecular weight: 331.86
Formula: C18H18ClNOS
CLOGP: 5.11
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 12.47
ALOGS: -5.63
ROTB: 4
Drug dosage:
Dose
Unit
Route
0.20
g
O
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
10 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
BDDCS (Biopharmaceutical Drug Disposition Classification System)
2
Hosey CM, Chan R, Benet LZ
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Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Neuroleptic malignant syndrome
60.89
57.13
14
345
12042
63476621
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Neuroleptic malignant syndrome
78.65
45.43
22
652
27537
79716177
Psychiatric symptom
57.22
45.43
13
661
7022
79736692
Colitis ischaemic
47.14
45.43
13
661
15346
79728368
Colectomy total
47.02
45.43
7
667
364
79743350
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N05AX11
NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Other antipsychotics
CHEBI has role
CHEBI:48278
serotonergic drugs
CHEBI has role
CHEBI:48539
alpha-adrenergic drugs
CHEBI has role
CHEBI:65191
atypical antipsychotic agent
MeSH PA
D014150
Antipsychotic Agents
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D002492
Central Nervous System Depressants
MeSH PA
D011619
Psychotropic Drugs
MeSH PA
D014149
Tranquilizing Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.25
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Beta-1 adrenergic receptor
GPCR
P08588
ADRB1_HUMAN
Ki
5.39
PDSP
Beta-2 adrenergic receptor
GPCR
P07550
ADRB2_HUMAN
Ki
5.64
PDSP
D(1A) dopamine receptor
GPCR
P21728
DRD1_HUMAN
Ki
7.54
CHEMBL
D(2) dopamine receptor
GPCR
P14416
DRD2_HUMAN
Ki
7.96
CHEMBL
Alpha-2A adrenergic receptor
GPCR
P08913
ADA2A_HUMAN
Ki
6.69
PDSP
Sodium-dependent serotonin transporter
Transporter
P31645
SC6A4_HUMAN
Ki
6.82
PDSP
Sodium-dependent noradrenaline transporter
Transporter
P23975
SC6A2_HUMAN
INHIBITOR
IC50
7.15
IUPHAR
5-hydroxytryptamine receptor 1A
GPCR
P08908
5HT1A_HUMAN
Ki
6.48
CHEMBL
5-hydroxytryptamine receptor 2A
GPCR
P28223
5HT2A_HUMAN
Ki
9.04
CHEMBL
5-hydroxytryptamine receptor 2C
GPCR
P28335
5HT2C_HUMAN
Ki
8.54
CHEMBL
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External reference:
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ID
Source
007029
NDDF
103
IUPHAR_LIGAND_ID
321641006
SNOMEDCT_US
395930007
SNOMEDCT_US
40003
RXNORM
4112
INN_ID
5736
PUBCHEM_CID
C0078849
UMLSCUI
C022172
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:32316
CHEBI
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Pharmaceutical products:
None
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zotepine