zidovudine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
uridine derivatives used as antiviral agents and as antineoplastics 2861 30516-87-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zidovudine
  • azidothymidine
  • azitidin
  • AZT
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
  • Molecular weight: 267.25
  • Formula: C10H13N5O4
  • CLOGP: 0.04
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 2
  • TPSA: 108.30
  • ALOGS: -1.21
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.60 g O
0.60 g P

Approvals:

DateAgencyCompanyOrphan
March 19, 1987 FDA VIIV HLTHCARE

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure during pregnancy 6476.35 49.54 1526 5925 26037 3352371
Foetal exposure during pregnancy 4587.73 49.54 1043 6408 14508 3363900
Premature baby 1967.96 49.54 458 6993 6795 3371613
Virologic failure 1440.46 49.54 266 7185 1088 3377320
Anaemia 1317.99 49.54 534 6917 53799 3324609
Stillbirth 1281.70 49.54 247 7204 1328 3377080
Immune reconstitution inflammatory syndrome 1280.65 49.54 263 7188 2050 3376358
Drug resistance 1169.95 49.54 277 7174 4386 3374022
Abortion spontaneous 1113.89 49.54 316 7135 10469 3367939
Maternal drugs affecting foetus 704.95 49.54 177 7274 3594 3374814
Lipodystrophy acquired 700.18 49.54 125 7326 398 3378010
HIV infection 667.97 49.54 118 7333 347 3378061
Caesarean section 620.39 49.54 166 7285 4360 3374048
Pregnancy 618.61 49.54 187 7264 7693 3370715
Maternal exposure during pregnancy 549.68 49.54 182 7269 10089 3368319
Premature delivery 545.60 49.54 133 7318 2372 3376036
Abortion induced 513.36 49.54 137 7314 3554 3374854
Live birth 489.41 49.54 102 7349 851 3377557
Maternal exposure during breast feeding 459.43 49.54 102 7349 1178 3377230
Foetal death 439.25 49.54 107 7344 1899 3376509
Hypertriglyceridaemia 435.61 49.54 103 7348 1601 3376807
Treatment failure 432.06 49.54 136 7315 6388 3372020
Pyrexia 417.29 49.54 283 7168 80832 3297576
Congenital anomaly 414.73 49.54 100 7351 1696 3376712
Blood lactic acid increased 406.52 49.54 93 7358 1240 3377168
Viral mutation identified 399.56 49.54 80 7371 533 3377875
Neutropenia 397.37 49.54 201 7250 33185 3345223
Atrial septal defect 382.18 49.54 103 7348 2770 3375638
Mitochondrial toxicity 374.99 49.54 64 7387 142 3378266
Polydactyly 370.76 49.54 70 7381 326 3378082
Premature rupture of membranes 363.83 49.54 78 7373 754 3377654
Foetal exposure during delivery 357.27 49.54 59 7392 97 3378311
Patent ductus arteriosus 314.96 49.54 76 7375 1291 3377117
Cardiac murmur 313.43 49.54 87 7364 2616 3375792
Ventricular septal defect 307.17 49.54 79 7372 1760 3376648
Small for dates baby 304.02 49.54 77 7374 1610 3376798
Foetal growth restriction 301.04 49.54 78 7373 1791 3376617
Premature labour 293.40 49.54 78 7373 1985 3376423
Hyperlactacidaemia 289.63 49.54 60 7391 483 3377925
Anaemia macrocytic 266.38 49.54 58 7393 606 3377802
Human immunodeficiency virus transmission 265.11 49.54 39 7412 10 3378398
Hepatitis 259.84 49.54 103 7348 9522 3368886
Vomiting 256.99 49.54 221 7230 89310 3289098
Neonatal disorder 256.83 49.54 57 7394 655 3377753
Aspartate aminotransferase increased 253.33 49.54 128 7323 20985 3357423
Kaposi's sarcoma 251.30 49.54 58 7393 804 3377604
Trisomy 21 247.90 49.54 51 7400 395 3378013
Pancytopenia 240.19 49.54 119 7332 18701 3359707
Alanine aminotransferase increased 236.85 49.54 127 7324 23513 3354895
Diarrhoea 227.88 49.54 221 7230 104127 3274281
Foetal distress syndrome 220.16 49.54 50 7401 642 3377766
Death 215.22 49.54 256 7195 152068 3226340
Portal hypertension 210.18 49.54 52 7399 983 3377425
Lipoatrophy 202.71 49.54 40 7411 244 3378164
Hypospadias 191.70 49.54 45 7406 674 3377734
Hepatomegaly 190.91 49.54 61 7390 2994 3375414
Sudden infant death syndrome 190.36 49.54 36 7415 169 3378239
Blood creatine phosphokinase increased 189.17 49.54 90 7361 12923 3365485
Cryptorchism 188.64 49.54 39 7412 310 3378098
Progressive external ophthalmoplegia 185.09 49.54 27 7424 5 3378403
Low birth weight baby 180.96 49.54 51 7400 1619 3376789
Hepatotoxicity 176.93 49.54 67 7384 5464 3372944
Pre-eclampsia 176.70 49.54 47 7404 1196 3377212
Anaemia neonatal 174.47 49.54 33 7418 155 3378253
Lactic acidosis 170.54 49.54 71 7380 7429 3370979
Talipes 167.31 49.54 42 7409 844 3377564
Exomphalos 162.61 49.54 32 7419 192 3378216
Heart disease congenital 159.12 49.54 41 7410 918 3377490
Eyelid ptosis 155.41 49.54 44 7407 1420 3376988
Jaundice 153.29 49.54 72 7379 10035 3368373
Gastrointestinal disorder 153.27 49.54 73 7378 10496 3367912
Gastroenteritis 151.78 49.54 56 7395 4245 3374163
Leukopenia 149.94 49.54 82 7369 15741 3362667
Normal newborn 149.83 49.54 43 7408 1458 3376950
Amniotic cavity infection 149.64 49.54 31 7420 249 3378159
Pathogen resistance 149.13 49.54 42 7409 1329 3377079
Treatment noncompliance 148.98 49.54 68 7383 8877 3369531
Gamma-glutamyltransferase increased 147.66 49.54 68 7383 9060 3369348
Lymphadenopathy 143.85 49.54 64 7387 7868 3370540
Genotype drug resistance test positive 143.24 49.54 29 7422 205 3378203
Sepsis 142.26 49.54 103 7348 32270 3346138
Abdominal distension 141.61 49.54 75 7376 13501 3364907
Developmental delay 140.55 49.54 37 7414 903 3377505
Meningomyelocele 137.93 49.54 28 7423 201 3378207
Hyperlipidaemia 137.02 49.54 53 7398 4575 3373833
Mitochondrial cytopathy 136.23 49.54 25 7426 96 3378312
Congenital hydronephrosis 134.61 49.54 27 7424 181 3378227
Thrombocytopenia 134.38 49.54 103 7348 35165 3343243
Bone marrow failure 133.45 49.54 62 7389 8425 3369983
Death neonatal 130.80 49.54 30 7421 403 3378005
Cytomegalovirus chorioretinitis 130.19 49.54 30 7421 412 3377996
Pneumonia 127.78 49.54 135 7316 70008 3308400
Splenomegaly 126.28 49.54 45 7406 3086 3375322
Alpha 1 foetoprotein abnormal 124.28 49.54 20 7431 25 3378383
Abdominal pain 121.80 49.54 109 7342 46116 3332292
Macrocytosis 120.30 49.54 27 7424 327 3378081
Malaria 118.94 49.54 25 7426 217 3378191
Rash maculo-papular 118.24 49.54 51 7400 5816 3372592
Weight decreased 116.53 49.54 100 7351 40011 3338397
Umbilical cord abnormality 116.49 49.54 24 7427 187 3378221
Hydrocephalus 113.21 49.54 35 7416 1538 3376870
Meningitis cryptococcal 108.60 49.54 26 7425 425 3377983
Ascites 106.89 49.54 55 7396 9322 3369086
Pallor 105.36 49.54 47 7404 5808 3372600
Drug interaction 105.14 49.54 101 7350 46711 3331697
Congenital central nervous system anomaly 104.11 49.54 24 7427 330 3378078
Premature separation of placenta 102.63 49.54 25 7426 441 3377967
Nodular regenerative hyperplasia 101.77 49.54 22 7429 221 3378187
Blood lactate dehydrogenase increased 100.80 49.54 47 7404 6433 3371975
Asthenia 99.80 49.54 115 7336 65550 3312858
Nausea 99.58 49.54 163 7288 129482 3248926
Coarctation of the aorta 98.74 49.54 23 7428 332 3378076
Blood bilirubin increased 98.22 49.54 54 7397 10455 3367953
Decreased appetite 97.87 49.54 92 7359 41398 3337010
Lipase increased 97.81 49.54 36 7415 2707 3375701
Placental disorder 97.60 49.54 23 7428 350 3378058
Genitalia external ambiguous 96.89 49.54 17 7434 47 3378361
HIV-associated neurocognitive disorder 96.52 49.54 18 7433 77 3378331
Neuropathy peripheral 96.23 49.54 63 7388 16744 3361664
Hypotonia 96.21 49.54 36 7415 2835 3375573
Diplopia 95.22 49.54 42 7409 5052 3373356
Congenital naevus 94.82 49.54 16 7435 32 3378376
CD4 lymphocytes decreased 94.73 49.54 26 7425 746 3377662
Dysmorphism 94.17 49.54 26 7425 763 3377645
Cough 93.28 49.54 88 7363 39770 3338638
Rash 92.78 49.54 115 7336 70706 3307702
Tuberculosis 92.31 49.54 35 7416 2858 3375550
Neutropenia neonatal 92.07 49.54 16 7435 41 3378367
Hyperbilirubinaemia 91.64 49.54 36 7415 3235 3375173
Mitochondrial myopathy 90.37 49.54 17 7434 77 3378331
Sepsis neonatal 89.66 49.54 20 7431 235 3378173
Gestational diabetes 88.86 49.54 27 7424 1118 3377290
Respiratory distress 86.46 49.54 46 7405 8342 3370066
Pinealoblastoma 86.38 49.54 13 7438 6 3378402
Ventricular hypertrophy 86.29 49.54 28 7423 1441 3376967
Cardiomegaly 85.08 49.54 37 7414 4301 3374107
Headache 84.94 49.54 126 7325 91854 3286554
Oral candidiasis 84.76 49.54 32 7419 2582 3375826
Skull malformation 83.69 49.54 19 7432 243 3378165
Ultrasound scan abnormal 83.61 49.54 18 7433 177 3378231
Congenital heart valve disorder 82.93 49.54 15 7436 52 3378356
Hepatic enzyme increased 82.72 49.54 53 7398 13572 3364836
Blood alkaline phosphatase increased 81.83 49.54 48 7403 10505 3367903
Hepatic function abnormal 81.66 49.54 49 7402 11178 3367230
Pancreatitis 80.57 49.54 53 7398 14192 3364216
Osteonecrosis 80.39 49.54 48 7403 10851 3367557
Blood triglycerides increased 80.18 49.54 36 7415 4514 3373894
Meconium stain 79.72 49.54 15 7436 68 3378340
Congenital pulmonary valve disorder 79.71 49.54 14 7437 39 3378369
Oligohydramnios 79.07 49.54 24 7427 990 3377418
Hydronephrosis 77.80 49.54 29 7422 2258 3376150
Microcephaly 77.69 49.54 19 7432 341 3378067
Haemoglobin decreased 76.86 49.54 70 7381 30224 3348184
Nervous system disorder 76.70 49.54 36 7415 4997 3373411
Neural tube defect 76.49 49.54 15 7436 88 3378320
Liver disorder 75.34 49.54 45 7406 10178 3368230
Viral load increased 75.31 49.54 22 7429 794 3377614
Stevens-Johnson syndrome 75.08 49.54 39 7412 6733 3371675
Cloacal exstrophy 74.56 49.54 12 7439 15 3378393
Large for dates baby 74.20 49.54 17 7434 227 3378181
Micrognathia 73.72 49.54 16 7435 164 3378244
Pulmonary tuberculosis 73.15 49.54 25 7426 1512 3376896
Congestive cardiomyopathy 72.80 49.54 26 7425 1792 3376616
Transaminases increased 71.95 49.54 38 7413 6786 3371622
Bladder agenesis 71.80 49.54 12 7439 22 3378386
Hepatic steatosis 71.32 49.54 34 7417 4886 3373522
Amylase increased 70.80 49.54 27 7424 2239 3376169
Diabetes mellitus 70.70 49.54 46 7405 12087 3366321
Hypertonia 70.51 49.54 26 7425 1964 3376444
Adrenogenital syndrome 70.46 49.54 12 7439 26 3378382
Gastrointestinal disorder congenital 69.85 49.54 12 7439 28 3378380
Mycobacterium avium complex infection 69.22 49.54 19 7432 545 3377863
Cryptococcosis 68.79 49.54 17 7434 319 3378089
Polyhydramnios 68.79 49.54 17 7434 319 3378089
Prenatal screening test abnormal 68.69 49.54 11 7440 13 3378395
Tachypnoea 68.65 49.54 30 7421 3526 3374882
Multiple-drug resistance 68.64 49.54 17 7434 322 3378086
Congenital hydrocephalus 68.14 49.54 15 7436 165 3378243
Hepatosplenomegaly 67.90 49.54 21 7430 923 3377485
Spine malformation 67.50 49.54 14 7437 113 3378295
Alpha 1 foetoprotein increased 67.10 49.54 15 7436 178 3378230
Pneumocystis jirovecii pneumonia 66.82 49.54 30 7421 3760 3374648
Drug reaction with eosinophilia and systemic symptoms 66.76 49.54 38 7413 7857 3370551
Neonatal aspiration 66.45 49.54 14 7437 123 3378285
Anal atresia 66.35 49.54 15 7436 188 3378220
Acute lymphocytic leukaemia 65.68 49.54 20 7431 834 3377574
Plagiocephaly 65.65 49.54 14 7437 131 3378277
Cleft palate 64.87 49.54 18 7433 538 3377870
Congenital foot malformation 64.11 49.54 14 7437 148 3378260
Hypercholesterolaemia 64.09 49.54 26 7425 2540 3375868
Dyspnoea 63.93 49.54 118 7333 102816 3275592
Single umbilical artery 63.58 49.54 13 7438 97 3378311
Lactate pyruvate ratio increased 63.31 49.54 10 7441 10 3378398
Torsade de pointes 63.21 49.54 27 7424 3002 3375406
Trisomy 18 63.01 49.54 13 7438 102 3378306
Tethered cord syndrome 62.97 49.54 12 7439 59 3378349
Twin pregnancy 62.71 49.54 15 7436 244 3378164
Cardiac malposition 62.54 49.54 11 7440 31 3378377
Renal impairment 62.24 49.54 50 7401 18211 3360197
Neonatal respiratory distress syndrome 62.08 49.54 22 7429 1482 3376926
Blood pyruvic acid increased 61.91 49.54 10 7441 13 3378395
Liver function test abnormal 61.05 49.54 43 7408 12858 3365550
Caudal regression syndrome 60.96 49.54 12 7439 72 3378336
Cleft lip and palate 60.93 49.54 16 7435 386 3378022
Platelet count increased 60.44 49.54 27 7424 3344 3375064
Dyslipidaemia 60.40 49.54 21 7430 1337 3377071
Cholestasis 59.92 49.54 31 7420 5306 3373102
Cushing's syndrome 59.89 49.54 20 7431 1126 3377282
Cachexia 59.32 49.54 21 7430 1410 3376998
Hepatic displacement 59.24 49.54 9 7442 5 3378403
Lymphadenitis 59.02 49.54 17 7434 583 3377825
Pericardial effusion 58.98 49.54 32 7419 6029 3372379
Necrotising colitis 58.56 49.54 16 7435 451 3377957
Acute hepatic failure 58.26 49.54 28 7423 4095 3374313
Ultrasound antenatal screen abnormal 58.18 49.54 12 7439 94 3378314
Cerebral toxoplasmosis 57.95 49.54 14 7437 238 3378170
Syndactyly 57.90 49.54 14 7437 239 3378169
Congenital choroid plexus cyst 57.73 49.54 12 7439 98 3378310
Neonatal asphyxia 56.94 49.54 14 7437 257 3378151
Congenital musculoskeletal anomaly 56.85 49.54 13 7438 172 3378236
Pyelocaliectasis 56.64 49.54 14 7437 263 3378145
Limb malformation 55.57 49.54 14 7437 285 3378123
Tachycardia 55.37 49.54 52 7399 23319 3355089
Proteinuria 54.75 49.54 28 7423 4678 3373730
Congenital cytomegalovirus infection 54.39 49.54 9 7442 15 3378393
Haematotoxicity 54.19 49.54 22 7429 2152 3376256
Hepatocellular injury 53.61 49.54 27 7424 4368 3374040
Hydrops foetalis 53.56 49.54 12 7439 144 3378264
Foetal heart rate abnormal 53.48 49.54 13 7438 227 3378181
Abdominal hernia 53.08 49.54 17 7434 838 3377570
Blood HIV RNA increased 53.03 49.54 12 7439 151 3378257
Congenital mitral valve incompetence 53.03 49.54 10 7441 46 3378362
Progressive multifocal leukoencephalopathy 52.85 49.54 24 7427 3088 3375320
Spina bifida 52.54 49.54 14 7437 358 3378050
Hypotonia neonatal 52.40 49.54 15 7436 503 3377905
Varices oesophageal 52.25 49.54 17 7434 882 3377526
Renal failure 52.14 49.54 59 7392 32881 3345527
Delivery 51.91 49.54 12 7439 167 3378241
Speech disorder developmental 51.88 49.54 14 7437 376 3378032
Diaphragmatic aplasia 51.72 49.54 8 7443 6 3378402
Foetal disorder 51.54 49.54 13 7438 266 3378142
Herpes simplex 51.41 49.54 19 7432 1444 3376964
Hemivertebra 51.39 49.54 10 7441 56 3378352
Gastritis 51.19 49.54 30 7421 6547 3371861
Fatigue 51.00 49.54 110 7341 107130 3271278
Cerebral ventricle dilatation 50.99 49.54 14 7437 402 3378006
Gynaecomastia 50.98 49.54 20 7431 1789 3376619
Cardiomyopathy 50.70 49.54 27 7424 4899 3373509
Congenital anomaly in offspring 50.38 49.54 10 7441 63 3378345
Acute kidney injury 50.01 49.54 71 7380 49612 3328796
Oesophageal candidiasis 49.85 49.54 17 7434 1021 3377387
Gastrointestinal malformation 49.72 49.54 10 7441 68 3378340

Pharmacologic Action:

SourceCodeDescription
ATC J05AF01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Nucleoside and nucleotide reverse transcriptase inhibitors
ATC J05AR01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HIV infections, combinations
ATC J05AR04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HIV infections, combinations
ATC J05AR05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HIV infections, combinations
FDA EPC N0000175462 Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor
FDA Chemical/Ingredient N0000175459 Nucleoside Analog
FDA MoA N0000009947 Nucleoside Reverse Transcriptase Inhibitors
CHEBI has role CHEBI:36044 antiviral drug
MeSH PA D019380 Anti-HIV Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D044966 Anti-Retroviral Agents
MeSH PA D000963 Antimetabolites
MeSH PA D000998 Antiviral Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D009676 Noxae
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors
MeSH PA D018894 Reverse Transcriptase Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Human immunodeficiency virus infection indication 86406008 DOID:526
Prevention of Maternal-Fetal Transmission of HIV indication
Prevention of HIV Infection after Exposure off-label use
Toxic amblyopia contraindication 965003
Myositis contraindication 26889001 DOID:633
Hepatic failure contraindication 59927004
Pancreatitis contraindication 75694006 DOID:4989
Large liver contraindication 80515008
Kidney disease contraindication 90708001 DOID:2527
Lactic acidosis contraindication 91273001 DOID:3650
Disorder of muscle contraindication 129565002 DOID:423
Steatosis of liver contraindication 197321007 DOID:9452
Acute pancreatitis contraindication 197456007 DOID:2913
Chronic pancreatitis contraindication 235494005
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001
Obesity contraindication 414916001 DOID:9970
HLA-B 5701 Positive Status contraindication
Drug Resistance to Anti-retroviral Therapy contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.17 acidic
pKa2 13.72 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
300MG TRIZIVIR VIIV HLTHCARE N021205 Nov. 14, 2000 RX TABLET ORAL 6294540 May 14, 2018 METHOD OF TREATMENT OF A PATIENT INFECTED WITH HIV

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thymidine kinase, cytosolic Kinase Ki 5.54 CHEMBL
Thymidylate kinase Kinase Ki 4.55 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR IC50 5.51 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 4 WOMBAT-PK
Reverse transcriptase/RNaseH Enzyme INHIBITOR IC50 8.52 CHEMBL CHEMBL
Thymidylate kinase Kinase Ki 4.55 CHEMBL
Pol polyprotein Enzyme IC50 8.22 CHEMBL
Gag-Pro-Pol polyprotein Polyprotein EC50 8.31 WOMBAT-PK
Reverse transcriptase/RNaseH Enzyme IC50 6.11 WOMBAT-PK
Thymidine kinase Unclassified IC50 4.90 CHEMBL
Reverse transcriptase Enzyme IC50 4.74 CHEMBL

External reference:

IDSource
DB00495 DRUGBANK_ID
4825 IUPHAR_LIGAND_ID
4019502 VUID
N0000147622 NUI
C0043474 UMLSCUI
D00413 KEGG_DRUG
CHEMBL129 ChEMBL_ID
4B9XT59T7S UNII
6118 INN_ID
35370 PUBCHEM_CID
4019502 VANDF
71929 MMSL
N0000006933 NDFRT
N0000147622 NDFRT
11413 RXNORM
27479000 SNOMEDCT_US
387151007 SNOMEDCT_US
5703 MMSL
d00034 MMSL
003019 NDDF
CHEBI:10110 CHEBI
D015215 MESH_DESCRIPTOR_UI
AZZ PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lamivudine and Zidovudine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5385 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
Lamivudine and Zidovudine HUMAN PRESCRIPTION DRUG LABEL 2 0378-5180 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
Zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 0378-6106 TABLET, FILM COATED 300 mg ORAL ANDA 17 sections
Zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 0527-1905 TABLET, FILM COATED 300 mg ORAL ANDA 17 sections
Combivir HUMAN PRESCRIPTION DRUG LABEL 2 16590-061 TABLET, FILM COATED 300 mg ORAL NDA 16 sections
Zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 21695-369 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
COMBIVIR HUMAN PRESCRIPTION DRUG LABEL 2 21695-846 TABLET, FILM COATED 300 mg ORAL NDA 18 sections
Lamivudine and Zidovudine HUMAN PRESCRIPTION DRUG LABEL 2 21695-996 TABLET, FILM COATED 300 mg ORAL ANDA 17 sections
LAMIVUDINE and ZIDOVUDINE HUMAN PRESCRIPTION DRUG LABEL 2 31722-506 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
Zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 31722-509 TABLET 300 mg ORAL ANDA 18 sections
Lamivudine and Zidovudine HUMAN PRESCRIPTION DRUG LABEL 2 31722-739 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
Lamivudine and Zidovudine HUMAN PRESCRIPTION DRUG LABEL 2 42291-363 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
Lamivudine and Zidovudine HUMAN PRESCRIPTION DRUG LABEL 2 43063-346 TABLET, FILM COATED 300 mg ORAL ANDA 17 sections
COMBIVIR HUMAN PRESCRIPTION DRUG LABEL 2 49702-202 TABLET, FILM COATED 300 mg ORAL NDA 18 sections
RETROVIR HUMAN PRESCRIPTION DRUG LABEL 1 49702-211 CAPSULE 100 mg ORAL NDA 18 sections
RETROVIR HUMAN PRESCRIPTION DRUG LABEL 1 49702-212 SYRUP 10 mg ORAL NDA 18 sections
RETROVIR HUMAN PRESCRIPTION DRUG LABEL 1 49702-213 INJECTION, SOLUTION 10 mg INTRAVENOUS NDA 18 sections
TRIZIVIR HUMAN PRESCRIPTION DRUG LABEL 3 49702-217 TABLET, FILM COATED 300 mg ORAL NDA 19 sections
Lamivudine and Zidovudine HUMAN PRESCRIPTION DRUG LABEL 2 50436-0597 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
Zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 52343-044 CAPSULE 100 mg ORAL ANDA 17 sections
Zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 52343-045 TABLET, FILM COATED 300 mg ORAL ANDA 17 sections
COMBIVIR HUMAN PRESCRIPTION DRUG LABEL 2 52959-546 TABLET, FILM COATED 300 mg ORAL NDA 18 sections
Zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 53104-0100 CAPSULE 100 mg ORAL ANDA 18 sections
Zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 53104-0101 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 53104-0105 SYRUP 50 mg ORAL ANDA 18 sections
Zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 53808-0812 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
Zidovudine HUMAN PRESCRIPTION DRUG LABEL 1 53808-0878 TABLET, FILM COATED 300 mg ORAL ANDA 18 sections
COMBIVIR HUMAN PRESCRIPTION DRUG LABEL 2 53808-0895 TABLET, FILM COATED 300 mg ORAL NDA 17 sections
TRIZIVIR HUMAN PRESCRIPTION DRUG LABEL 3 53808-0990 TABLET, FILM COATED 300 mg ORAL NDA 19 sections
Lamivudine and Zidovudine HUMAN PRESCRIPTION DRUG LABEL 2 55700-096 TABLET, FILM COATED 300 mg ORAL ANDA 17 sections