xipamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, sulfamoylbenzoic acid derivatives	2853	14293-44-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: xipamide chronexan diurex diurexan	A sulfamoylbenzamide analog of CLOPAMIDE. It is diuretic and saluretic with antihypertensive activity. It is bound to PLASMA PROTEINS, thus has a delayed onset and prolonged action. Molecular weight: 354.81 Formula: C15H15ClN2O4S CLOGP: 2.12 LIPINSKI: 0 HAC: 6 HDO: 3 TPSA: 109.49 ALOGS: -4.16 ROTB: 3

Molecule

Description

Molfile Inchi Smiles

Synonyms:

xipamide
chronexan
diurex
diurexan

A sulfamoylbenzamide analog of CLOPAMIDE. It is diuretic and saluretic with antihypertensive activity. It is bound to PLASMA PROTEINS, thus has a delayed onset and prolonged action.

Molecular weight: 354.81
Formula: C15H15ClN2O4S
CLOGP: 2.12
LIPINSKI: 0
HAC: 6
HDO: 3
TPSA: 109.49
ALOGS: -4.16
ROTB: 3

Drug dosage:

Dose	Unit	Route
20	mg	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	70 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	265.62	34.92	165	4054	201237	63283566
Product prescribing error	183.26	34.92	68	4151	26221	63458582
Anaemia	135.68	34.92	129	4090	293301	63191502
Lymphatic fistula	111.06	34.92	22	4197	764	63484039
Femoral hernia incarcerated	109.57	34.92	22	4197	819	63483984
Eructation	106.68	34.92	34	4185	8299	63476504
Pancreatic steatosis	105.43	34.92	22	4197	994	63483809
Haematochezia	105.01	34.92	57	4162	53487	63431316
Oedema peripheral	104.30	34.92	92	4127	189419	63295384
Wound infection pseudomonas	99.56	34.92	22	4197	1306	63483497

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product prescribing error	328.18	36.39	110	3127	22817	34930877
General physical health deterioration	204.93	36.39	134	3103	128135	34825559
Labelled drug-drug interaction medication error	183.39	36.39	64	3173	14875	34938819
Dyspnoea	128.94	36.39	165	3072	376617	34577077
Product monitoring error	99.64	36.39	30	3207	4351	34949343
Therapeutic drug monitoring analysis incorrectly performed	84.34	36.39	16	3221	312	34953382
Dehydration	69.39	36.39	72	3165	129897	34823797
Peripheral arterial occlusive disease	63.74	36.39	23	3214	5851	34947843
Cold sweat	48.72	36.39	22	3215	9965	34943729
Hypotension	45.83	36.39	77	3160	221572	34732122

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product prescribing error	500.50	32.90	178	7072	44635	79692503
General physical health deterioration	457.94	32.90	293	6957	274945	79462193
Product monitoring error	169.61	32.90	53	7197	8853	79728285
Dyspnoea	147.34	32.90	271	6979	856754	78880384
Labelled drug-drug interaction medication error	145.95	32.90	64	7186	27586	79709552
Oedema peripheral	131.69	32.90	137	7113	252151	79484987
Anaemia	124.50	32.90	176	7074	444839	79292299
Haematochezia	115.18	32.90	81	7169	87564	79649574
Lymphatic fistula	103.69	32.90	22	7228	781	79736357
Femoral hernia incarcerated	102.65	32.90	22	7228	820	79736318

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C03BA10	CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, EXCL. THIAZIDES Sulfonamides, plain
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D004232	Diuretics
MeSH PA	D045283	Natriuretic Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Edema	indication	267038008

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.65	acidic
pKa2	9.76	acidic
pKa3	10.4	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
004068	NDDF
11371	RXNORM
173968	MMSL
26618	PUBCHEM_CID
2689	INN_ID
317968004	SNOMEDCT_US
395923001	SNOMEDCT_US
4S9EY0NUEC	UNII
7900	IUPHAR_LIGAND_ID
C0043355	UMLSCUI

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Pharmaceutical products:

None