bambuterol indications/contra

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 285 81732-65-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bambuterol
  • bambudil
  • terbutaline bisdimethylcarbamate
  • (+/-)-Bambuterol
  • bambuterol hydrochloride
  • bambuterol HCl
selective inhibitor of butyrylcholinesterase & acetylcholinesterase
  • Molecular weight: 367.45
  • Formula: C18H29N3O5
  • CLOGP: 0.56
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 91.34
  • ALOGS: -2.89
  • ROTB: 8

Drug dosage:

DoseUnitRoute
20 mg O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1990 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC R03CC12 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001337 Autonomic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:66993 tocolytic agent
CHEBI has role CHEBI:35524 sympathomimetic agent
CHEBI has role CHEBI:35522 beta-adrenergic agonist
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:35523 bronchodilator agent
CHEBI has role CHEBI:49167 anti-asthmatic drug

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.12 acidic
pKa2 8.92 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 2D6 Enzyme IC50 5.70 DRUG MATRIX
Beta-2 adrenergic receptor GPCR WOMBAT-PK
Acetylcholinesterase Enzyme Ki 3.25 WOMBAT-PK
Cholinesterase Enzyme INHIBITOR IC50 8.50 IUPHAR

External reference:

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IDSource
C0052944 UMLSCUI
6601 IUPHAR_LIGAND_ID
D07377 KEGG_DRUG
786Q84QZ3F UNII
81732-46-9 SECONDARY_CAS_RN
18751 RXNORM
349923005 SNOMEDCT_US
396462008 SNOMEDCT_US
004156 NDDF
54766 PUBCHEM_CID
CHEMBL521589 ChEMBL_ID
C047766 MESH_SUPPLEMENTAL_RECORD_UI
DB01408 DRUGBANK_ID
5304 INN_ID
CHEBI:553827 CHEBI

Pharmaceutical products:

None