voglibose indications/contra

Stem definitionDrug idCAS RN
antihyperglycaemics 2845 83480-29-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • voglibose
  • glustat
  • voglistat
  • AO-128
  • Molecular weight: 267.28
  • Formula: C10H21NO7
  • CLOGP: -0.93
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 8
  • TPSA: 153.64
  • ALOGS: -0.15
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.60 mg O

Approvals:

DateAgencyCompanyOrphan
Aug. 20, 1994 PMDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 70.98 64.37 15 70 14303 3371471

Pharmacologic Action:

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SourceCodeDescription
ATC A10BF03 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Alpha glucosidase inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D065089 Glycoside Hydrolase Inhibitors
MeSH PA D007004 Hypoglycemic Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352
Glucosylceramide beta-glucosidase deficiency indication 190794006 DOID:1926
Impaired renal function disorder contraindication 197663003
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006 DOID:574
Breastfeeding (mother) contraindication 413712001

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.5 acidic
pKa2 12.5 acidic
pKa3 8.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lysosomal alpha-glucosidase Enzyme INHIBITOR IC50 7.15 CHEMBL SCIENTIFIC LITERATURE
Glycogen debranching enzyme Enzyme IC50 4.15 CHEMBL
Lysosomal alpha-glucosidase Enzyme IC50 6.96 CHEMBL
Sucrase-isomaltase, intestinal Enzyme IC50 7.15 CHEMBL

External reference:

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IDSource
D01665 KEGG_DRUG
444020 PUBCHEM_CID
010940 NDDF
CHEBI:32300 CHEBI
CHEMBL476960 ChEMBL_ID
DB04878 DRUGBANK_ID
S77P977AG8 UNII
6797 INN_ID
C102817 MESH_SUPPLEMENTAL_RECORD_UI
VOG PDB_CHEM_ID

Pharmaceutical products:

None