dihydrotachysterol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 2841 67-96-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dihydrotachysterol
  • dichystrolum
A VITAMIN D that can be regarded as a reduction product of vitamin D2.
  • Molecular weight: 398.68
  • Formula: C28H46O
  • CLOGP: 9.85
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -6.50
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.04 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC02 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
CHEBI has role CHEBI:50646 antiosteoporotic
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypophosphatemia indication 4996001
Hypocalcemia indication 5291005
Tetany indication 10629009
Hypoparathyroidism indication 36976004 DOID:11199
Rickets indication 41345002 DOID:10609
Renal osteodystrophy off-label use 16726004 DOID:13068
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Hypercalcemia contraindication 66931009 DOID:12678
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Arteriosclerosis obliterans contraindication 361133006 DOID:5160




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor WOMBAT-PK

External reference:

IDSource
4018234 VUID
N0000146565 NUI
D00299 KEGG_DRUG
4018234 VANDF
4021907 VANDF
C0012319 UMLSCUI
CHEBI:4591 CHEBI
CHEMBL2356023 ChEMBL_ID
D004097 MESH_DESCRIPTOR_UI
DB01070 DRUGBANK_ID
5311071 PUBCHEM_CID
1610 INN_ID
R5LM3H112R UNII
3429 RXNORM
4601 MMSL
d03125 MMSL
001015 NDDF
126235007 SNOMEDCT_US
20237006 SNOMEDCT_US

Pharmaceutical products:

None