retinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
retinol derivatives 2831 68-26-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vitamin A1
  • vitamin A
  • retinol
  • retinol (vit A)
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
  • Molecular weight: 286.46
  • Formula: C20H30O
  • CLOGP: 6.40
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -4.58
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 TU O
50 TU P
800 U N

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 135.76 10.33 3 51932 183723 63253364
Synovitis 124.52 10.33 7 51928 186911 63250176
Contraindicated product administered 121.36 10.33 17 51918 217631 63219456
Hand deformity 116.28 10.33 3 51932 159454 63277633
Systemic lupus erythematosus 108.21 10.33 20 51915 208898 63228189
Pneumonia aspiration 107.66 10.33 137 51798 34403 63402684
Completed suicide 95.35 10.33 6 51929 145667 63291420
Glossodynia 95.08 10.33 16 51919 178860 63258227
Product use issue 83.40 10.33 38 51897 220482 63216605
Maternal exposure during pregnancy 83.10 10.33 38 51897 220024 63217063
Anti-cyclic citrullinated peptide antibody positive 81.78 10.33 3 51932 116209 63320878
Pericarditis 81.60 10.33 7 51928 131572 63305515
Gastrooesophageal reflux disease 80.77 10.33 215 51720 95424 63341663
Product dose omission issue 75.56 10.33 385 51550 233928 63203159
Diarrhoea 74.89 10.33 903 51032 714463 62722624
Toxicity to various agents 74.55 10.33 56 51879 247194 63189893
Drug ineffective 74.38 10.33 526 51409 1044239 62392848
Blood magnesium increased 70.87 10.33 39 51896 2999 63434088
Pleural thickening 70.00 10.33 38 51897 2845 63434242
Wound 68.47 10.33 24 51911 163239 63273848
Presbyacusis 64.70 10.33 36 51899 2829 63434258
Infusion related reaction 62.69 10.33 65 51870 245456 63191631
Muscle spasms 62.29 10.33 273 51662 155877 63281210
Product use in unapproved indication 61.50 10.33 35 51900 179045 63258042
Pleural fibrosis 60.83 10.33 37 51898 3435 63433652
Duodenal ulcer perforation 55.86 10.33 4 51931 87205 63349882
Off label use 55.76 10.33 324 51611 674138 62762949
Deafness neurosensory 51.80 10.33 38 51897 4817 63432270
Arthropathy 49.56 10.33 72 51863 234720 63202367
Cyst 48.86 10.33 59 51876 14040 63423047
Unevaluable event 47.97 10.33 120 51815 51266 63385821
Device expulsion 47.76 10.33 95 51840 34827 63402260
Full blood count decreased 47.23 10.33 80 51855 25944 63411143
Fall 47.03 10.33 509 51426 391825 63045262
Lower respiratory tract infection 45.21 10.33 26 51909 132281 63304806
Therapeutic product effect decreased 45.08 10.33 55 51880 193132 63243955
Fatigue 43.58 10.33 990 50945 887038 62550049
Drug intolerance 42.65 10.33 121 51814 308540 63128547
Epigastric discomfort 42.63 10.33 39 51896 6741 63430346
Neuropathy peripheral 42.50 10.33 195 51740 113472 63323615
Somnolence 42.01 10.33 270 51665 178415 63258672
Helicobacter infection 41.81 10.33 12 51923 92773 63344314
Coma 41.12 10.33 131 51804 64233 63372854
Therapy cessation 39.44 10.33 81 51854 30376 63406711
Hepatic enzyme increased 38.93 10.33 66 51869 202262 63234825
Folliculitis 37.98 10.33 6 51929 70311 63366776
Psoriasis 36.93 10.33 155 51780 86802 63350285
Intentional overdose 36.48 10.33 8 51927 74144 63362943
Dry eye 35.77 10.33 93 51842 40668 63396419
Therapeutic product effect incomplete 35.55 10.33 30 51905 125026 63312061
Device dislocation 35.24 10.33 70 51865 25635 63411452
Intentional product use issue 33.59 10.33 33 51902 127859 63309228
Dizziness 33.00 10.33 514 51421 429411 63007676
Flatulence 32.34 10.33 81 51854 34621 63402466
Discomfort 31.82 10.33 55 51880 167319 63269768
Joint swelling 31.68 10.33 149 51786 327517 63109570
Constipation 30.78 10.33 300 51635 224643 63212444
Exposure during pregnancy 30.60 10.33 50 51885 155497 63281590
Deep vein thrombosis 30.02 10.33 142 51793 83658 63353429
Osteopenia 29.71 10.33 56 51879 19729 63417358
Drug hypersensitivity 29.61 10.33 142 51793 310545 63126542
Drug interaction 29.34 10.33 93 51842 229038 63208049
Asthenia 29.18 10.33 458 51477 383146 63053941
Infective pulmonary exacerbation of cystic fibrosis 29.10 10.33 36 51899 8781 63428306
Blood potassium increased 28.97 10.33 53 51882 18256 63418831
Liver injury 28.83 10.33 7 51928 60513 63376574
Feeling abnormal 28.81 10.33 214 51721 148178 63288909
Nausea 28.70 10.33 907 51028 853564 62583523
Treatment failure 28.23 10.33 77 51858 198966 63238121
Hypoaesthesia 27.83 10.33 234 51701 168159 63268928
C-reactive protein increased 27.81 10.33 22 51913 94685 63342402
Choanal stenosis 26.45 10.33 6 51929 27 63437060
General physical health deterioration 26.31 10.33 81 51854 201321 63235766
Alopecia 26.28 10.33 165 51770 337371 63099716
Pneumonia 25.73 10.33 520 51415 456247 62980840
Overdose 25.55 10.33 34 51901 115044 63322043
Laboratory test abnormal 25.27 10.33 63 51872 26849 63410238
Rheumatic fever 24.88 10.33 3 51932 43108 63393979
Blister 23.46 10.33 44 51891 129770 63307317
Haemoglobin decreased 23.42 10.33 201 51734 145284 63291803
Plasma cell myeloma 22.85 10.33 73 51862 35832 63401255
Bone cyst 22.61 10.33 17 51918 2237 63434850
Memory impairment 22.34 10.33 154 51781 104104 63332983
Injection site reaction 22.30 10.33 101 51834 58423 63378664
Granulomatous liver disease 20.99 10.33 11 51924 767 63436320
Irritable bowel syndrome 20.80 10.33 22 51913 82390 63354697
Suicide attempt 20.76 10.33 12 51923 60906 63376181
Injection site pain 20.72 10.33 179 51756 129621 63307466
Ill-defined disorder 20.44 10.33 22 51913 81733 63355354
Rheumatoid arthritis 20.30 10.33 123 51812 253696 63183391
Skin lesion 20.05 10.33 63 51872 30658 63406429
Pelvic pain 19.97 10.33 38 51897 13481 63423606
Swelling 19.23 10.33 139 51796 275239 63161848
Headache 18.58 10.33 662 51273 632579 62804508
Fluid retention 18.44 10.33 97 51838 59589 63377498
Dry skin 17.95 10.33 93 51842 56794 63380293
Blood potassium decreased 17.90 10.33 75 51860 41951 63395136
Aorta hypoplasia 17.50 10.33 6 51929 143 63436944
Osteochondritis 16.67 10.33 4 51931 24 63437063
Osteosclerosis 16.38 10.33 18 51917 3870 63433217
Enterobacter infection 16.37 10.33 14 51921 2213 63434874
Dehydration 16.34 10.33 215 51720 173139 63263948
Hip fracture 16.16 10.33 57 51878 29417 63407670
Underdose 15.84 10.33 54 51881 27402 63409685
Abdominal discomfort 15.81 10.33 177 51758 320708 63116379
Eye swelling 15.56 10.33 49 51886 23869 63413218
Anxiety 15.11 10.33 256 51679 217285 63219802
Influenza like illness 15.08 10.33 100 51835 66724 63370363
Injection site erythema 15.04 10.33 118 51817 83056 63354031
Back pain 14.92 10.33 301 51634 263844 63173243
Dyspnoea exertional 14.69 10.33 92 51843 60210 63376877
Hepatic function abnormal 14.66 10.33 6 51929 37136 63399951
Body height decreased 14.48 10.33 28 51907 10050 63427037
COVID-19 14.40 10.33 46 51889 113057 63324030
Tooth disorder 14.21 10.33 53 51882 28104 63408983
Injection site haemorrhage 14.19 10.33 48 51887 24266 63412821
Hospitalisation 13.92 10.33 118 51817 84963 63352124
Weight decreased 13.88 10.33 310 51625 276488 63160599
Vision blurred 13.75 10.33 125 51810 91799 63345288
Hot flush 13.70 10.33 80 51855 51079 63386008
Depression 13.56 10.33 231 51704 196261 63240826
Hepatocellular injury 13.37 10.33 3 51932 27378 63409709
Paraesthesia 13.29 10.33 191 51744 156775 63280312
Pain in extremity 13.26 10.33 360 51575 331126 63105961
Oedema peripheral 13.15 10.33 223 51712 189288 63247799
Intestinal dilatation 13.02 10.33 11 51924 1711 63435376
Tremor 12.87 10.33 165 51770 132074 63305013
International normalised ratio decreased 12.69 10.33 17 51918 4484 63432603
Abdominal distension 12.56 10.33 117 51818 86498 63350589
Nasal congestion 12.34 10.33 94 51841 65566 63371521
Urinary tract infection 12.21 10.33 293 51642 264391 63172696
Tracheo-oesophageal fistula 12.18 10.33 7 51928 585 63436502
Plasma cell myeloma recurrent 12.05 10.33 14 51921 3199 63433888
Pollakiuria 12.01 10.33 50 51885 27887 63409200
Pulmonary arterial hypertension 11.82 10.33 43 51892 22534 63414553
Agranulocytosis 11.79 10.33 3 51932 25131 63411956
Respiratory arrest 11.75 10.33 6 51929 32639 63404448
Asthma 11.73 10.33 59 51876 127502 63309585
Hip arthroplasty 11.71 10.33 13 51922 47633 63389454
Chills 11.69 10.33 143 51792 113235 63323852
White blood cell count decreased 11.67 10.33 169 51766 138935 63298152
Vaginal haemorrhage 11.66 10.33 49 51886 27438 63409649
Hypervolaemia 11.55 10.33 50 51885 28363 63408724
Pulmonary embolism 11.53 10.33 146 51789 116538 63320549
Hiatus hernia strangulated 11.49 10.33 5 51930 230 63436857
Hypoxia 11.46 10.33 86 51849 59706 63377381
Bone hypertrophy 11.45 10.33 6 51929 418 63436669
Anaphylactic reaction 11.42 10.33 23 51912 66077 63371010
Multiple organ dysfunction syndrome 11.38 10.33 18 51917 56734 63380353
Skin discolouration 11.35 10.33 61 51874 37767 63399320
Depressed level of consciousness 11.25 10.33 21 51914 62057 63375030
Administration site swelling 11.24 10.33 9 51926 1298 63435789
Balance disorder 11.23 10.33 112 51823 84310 63352777
Dysgeusia 11.21 10.33 71 51864 46639 63390448
Red blood cell sedimentation rate increased 10.81 10.33 12 51923 43970 63393117
Insomnia 10.76 10.33 241 51694 215011 63222076
Anaphylactic shock 10.75 10.33 3 51932 23630 63413457
Drug eruption 10.74 10.33 5 51930 28689 63408398
Intentional product misuse 10.69 10.33 21 51914 60896 63376191
Cholelithiasis 10.69 10.33 67 51868 43858 63393229
Type 2 diabetes mellitus 10.38 10.33 23 51912 63845 63373242
Failure to thrive 10.35 10.33 20 51915 7178 63429909

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 78.38 11.36 137 28079 419387 34509328
Drug abuse 61.23 11.36 5 28211 99091 34829624
Fatigue 58.26 11.36 503 27713 370150 34558565
Completed suicide 57.85 11.36 6 28210 98162 34830553
Product use in unapproved indication 45.40 11.36 19 28197 117480 34811235
Toxicity to various agents 43.42 11.36 59 28157 200303 34728412
Product dose omission issue 43.04 11.36 201 28015 119510 34809205
Respiratory tract infection bacterial 42.20 11.36 23 28193 1759 34926956
Drug interaction 40.94 11.36 75 28141 225871 34702844
Plasma cell myeloma 38.89 11.36 97 28119 41940 34886775
Respiratory tract infection viral 37.30 11.36 24 28192 2493 34926222
Laboratory test abnormal 36.72 11.36 62 28154 20329 34908386
Full blood count decreased 35.27 11.36 57 28159 18031 34910684
White blood cell count decreased 34.84 11.36 161 28055 95284 34833431
Diarrhoea 30.07 11.36 461 27755 389451 34539264
Fall 28.97 11.36 270 27946 202615 34726100
Infective pulmonary exacerbation of cystic fibrosis 28.17 11.36 31 28185 6770 34921945
Adverse drug reaction 27.44 11.36 68 28148 29274 34899441
Asthenia 26.77 11.36 309 27907 244942 34683773
Viral infection 25.85 11.36 49 28167 17574 34911141
Influenza 25.40 11.36 93 28123 49573 34879142
General physical health deterioration 24.62 11.36 41 28175 128228 34800487
Sinusitis 23.29 11.36 80 28136 41322 34887393
Interstitial lung disease 21.53 11.36 13 28203 65269 34863446
Neuropathy peripheral 21.10 11.36 127 28089 83136 34845579
Psoriasis 20.97 11.36 74 28142 38738 34889977
Drug ineffective 20.65 11.36 253 27963 456498 34472217
Rash 20.13 11.36 271 27945 222481 34706234
Muscle spasms 20.03 11.36 116 28100 74885 34853830
Intentional product misuse 19.95 11.36 6 28210 45605 34883110
Dizziness 19.81 11.36 266 27950 218255 34710460
Platelet count decreased 18.93 11.36 163 28053 119554 34809161
Haemoglobin decreased 18.87 11.36 164 28052 120608 34808107
Fibrin D dimer increased 18.72 11.36 20 28196 4224 34924491
Flatulence 18.64 11.36 48 28168 21150 34907565
Hypervitaminosis A 18.27 11.36 4 28212 15 34928700
Peripheral swelling 17.06 11.36 113 28103 76428 34852287
Thrombosis 16.85 11.36 83 28133 50375 34878340
Foetal exposure during pregnancy 16.68 11.36 5 28211 38096 34890619
Overdose 16.65 11.36 30 28186 91029 34837686
Hepatic function abnormal 15.83 11.36 8 28208 44355 34884360
Pneumonia 15.68 11.36 393 27823 362234 34566481
Febrile neutropenia 15.15 11.36 58 28158 136791 34791924
Multiple organ dysfunction syndrome 15.13 11.36 24 28192 76542 34852173
Constipation 14.64 11.36 172 28044 136810 34791905
Weight decreased 14.50 11.36 211 28005 176090 34752625
Treatment failure 14.44 11.36 10 28206 46687 34882028
Dehydration 14.24 11.36 164 28052 129805 34798910
Coma 13.83 11.36 10 28206 45668 34883047
Leukopenia 13.09 11.36 19 28197 62837 34865878
Prealbumin decreased 12.52 11.36 4 28212 77 34928638
Small intestinal obstruction 12.39 11.36 33 28183 14833 34913882
Headache 12.37 11.36 229 27987 200406 34728309
Cardiac disorder 12.36 11.36 68 28148 43058 34885657
Eye infection 12.29 11.36 15 28201 3658 34925057
Memory impairment 12.22 11.36 68 28148 43250 34885465
Blood testosterone decreased 11.76 11.36 16 28200 4341 34924374
Balance disorder 11.59 11.36 64 28152 40590 34888125
Hypoaesthesia 11.52 11.36 87 28129 61357 34867358

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 149.83 9.95 12 63268 245755 79435353
Toxicity to various agents 117.87 9.95 97 63183 421443 79259665
Drug abuse 107.97 9.95 5 63275 162686 79518422
Off label use 104.61 9.95 370 62910 906845 78774263
Synovitis 95.76 9.95 6 63274 150728 79530380
Product use in unapproved indication 93.17 9.95 41 63239 250318 79430790
Product dose omission issue 84.10 9.95 404 62876 247133 79433975
Drug ineffective 78.41 9.95 520 62760 1080393 78600715
Gastrooesophageal reflux disease 77.08 9.95 219 63061 104027 79577081
Contraindicated product administered 74.19 9.95 17 63263 157521 79523587
Drug interaction 69.93 9.95 140 63140 415043 79266065
Hand deformity 66.41 9.95 4 63276 103915 79577193
Pemphigus 66.25 9.95 3 63277 99579 79581529
Pneumonia aspiration 63.08 9.95 154 63126 66813 79614295
Device expulsion 62.14 9.95 89 63191 25772 79655336
Fall 60.14 9.95 621 62659 487008 79194100
Infective pulmonary exacerbation of cystic fibrosis 60.13 9.95 62 63218 12789 79668319
Pleural thickening 58.99 9.95 34 63246 2948 79678160
Presbyacusis 57.12 9.95 32 63248 2628 79678480
Fatigue 56.98 9.95 1044 62236 928683 78752425
Blood magnesium increased 56.42 9.95 35 63245 3471 79677637
Diarrhoea 54.03 9.95 989 62291 879500 78801608
Anti-cyclic citrullinated peptide antibody positive 53.74 9.95 3 63277 83140 79597968
Muscle spasms 53.50 9.95 277 63003 174453 79506655
Systemic lupus erythematosus 53.32 9.95 15 63265 121134 79559974
Intentional overdose 52.83 9.95 10 63270 105950 79575158
Product use issue 48.50 9.95 57 63223 209765 79471343
Pleural fibrosis 46.23 9.95 33 63247 4134 79676974
General physical health deterioration 46.13 9.95 93 63187 275145 79405963
Dizziness 46.11 9.95 628 62652 525813 79155295
Asthenia 45.06 9.95 611 62669 511078 79170030
Infusion related reaction 43.75 9.95 72 63208 230165 79450943
Plasma cell myeloma 43.43 9.95 116 63164 53143 79627965
Lower respiratory tract infection 42.30 9.95 25 63255 129195 79551913
Therapy cessation 41.53 9.95 92 63188 37470 79643638
Glossodynia 39.89 9.95 16 63264 103321 79577787
Respiratory tract infection bacterial 39.28 9.95 23 63257 2054 79679054
Epigastric discomfort 38.58 9.95 39 63241 7857 79673251
Helicobacter infection 38.32 9.95 5 63275 69699 79611409
Full blood count decreased 38.28 9.95 73 63207 26746 79654362
Intentional product misuse 37.95 9.95 14 63266 95151 79585957
Overdose 37.48 9.95 55 63225 184151 79496957
Maternal exposure during pregnancy 37.37 9.95 32 63248 136506 79544602
Pericarditis 37.30 9.95 18 63262 104218 79576890
Therapeutic product effect incomplete 36.61 9.95 35 63245 141610 79539498
Deep vein thrombosis 35.82 9.95 190 63090 120729 79560379
Deafness neurosensory 35.42 9.95 35 63245 6863 79674245
Haemoglobin decreased 35.40 9.95 299 62981 221820 79459288
Cyst 35.27 9.95 49 63231 13791 79667317
Dehydration 33.87 9.95 323 62957 247864 79433244
Device dislocation 33.81 9.95 68 63212 25902 79655206
Duodenal ulcer perforation 33.54 9.95 6 63274 66205 79614903
Drug intolerance 32.10 9.95 105 63175 264014 79417094
Somnolence 31.12 9.95 308 62972 238673 79442435
Osteopenia 30.02 9.95 53 63227 18311 79662797
Flatulence 29.86 9.95 88 63192 42636 79638472
Intentional product use issue 29.42 9.95 47 63233 152065 79529043
Respiratory tract infection viral 28.41 9.95 25 63255 4234 79676874
Fluid retention 28.19 9.95 120 63160 69689 79611419
Drug hypersensitivity 27.34 9.95 133 63147 298783 79382325
Hepatic enzyme increased 27.05 9.95 66 63214 182544 79498564
Dry eye 26.71 9.95 77 63203 36854 79644254
Unevaluable event 25.99 9.95 100 63180 55485 79625623
Hypervitaminosis A 25.79 9.95 6 63274 32 79681076
Nausea 25.18 9.95 962 62318 956234 78724874
Hospitalisation 25.18 9.95 144 63136 94092 79587016
Therapeutic response decreased 24.76 9.95 11 63269 66842 79614266
Interstitial lung disease 24.52 9.95 32 63248 112568 79568540
Joint swelling 24.38 9.95 132 63148 288514 79392594
Feeling abnormal 24.14 9.95 212 63068 158987 79522121
Hepatic function abnormal 24.13 9.95 14 63266 73093 79608015
Blood potassium increased 24.10 9.95 64 63216 29211 79651897
Folliculitis 24.10 9.95 7 63273 55373 79625735
Pneumonia 23.58 9.95 688 62592 659558 79021550
Wound 23.32 9.95 35 63245 116144 79564964
Suicide attempt 23.22 9.95 19 63261 82913 79598195
Depressed level of consciousness 22.59 9.95 26 63254 96626 79584482
Hospice care 22.59 9.95 34 63246 10290 79670818
Hip fracture 22.11 9.95 64 63216 30697 79650411
Myelosuppression 21.88 9.95 3 63277 40293 79640815
Injection site pain 21.85 9.95 177 63103 129661 79551447
Small intestinal obstruction 21.83 9.95 59 63221 27213 79653895
Hypervolaemia 21.79 9.95 79 63201 42611 79638497
Pelvic pain 21.08 9.95 38 63242 13343 79667765
Multiple organ dysfunction syndrome 20.67 9.95 40 63240 120206 79560902
Treatment failure 20.55 9.95 68 63212 170418 79510690
Neuropathy peripheral 20.31 9.95 186 63094 141119 79539989
Osteosclerosis 20.11 9.95 20 63260 3951 79677157
Dyspnoea exertional 20.04 9.95 128 63152 86945 79594163
Hypoaesthesia 19.97 9.95 224 63056 179128 79501980
Arthropathy 19.76 9.95 73 63207 177038 79504070
C-reactive protein increased 19.61 9.95 46 63234 128981 79552127
Weight decreased 19.59 9.95 393 62887 354805 79326303
Blood potassium decreased 19.59 9.95 81 63199 46431 79634677
Influenza like illness 19.43 9.95 110 63170 71597 79609511
Eosinophilia 19.24 9.95 6 63274 45339 79635769
Drug resistance 18.99 9.95 5 63275 42208 79638900
Viral infection 18.98 9.95 76 63204 42940 79638168
Multiple sclerosis relapse 18.79 9.95 80 63200 46453 79634655
Pulmonary embolism 18.49 9.95 213 63067 171441 79509667
Depression 18.25 9.95 257 63023 216533 79464575
Febrile neutropenia 18.22 9.95 108 63172 230891 79450217
White blood cell count decreased 17.82 9.95 228 63052 188060 79493048
Mental status changes 17.67 9.95 102 63178 66857 79614251
Injection site reaction 17.55 9.95 88 63192 54697 79626411
Cytomegalovirus infection 17.47 9.95 6 63274 42638 79638470
Constipation 17.24 9.95 318 62962 282732 79398376
Cholestasis 17.16 9.95 10 63270 52099 79629009
Headache 17.12 9.95 657 62623 653115 79027993
Liver injury 17.09 9.95 12 63268 56602 79624506
Therapeutic product effect decreased 16.71 9.95 70 63210 163793 79517315
Leukopenia 16.56 9.95 43 63237 116470 79564638
COVID-19 16.30 9.95 67 63213 157607 79523501
Coma 16.28 9.95 136 63144 100513 79580595
Osteochondritis 15.69 9.95 4 63276 33 79681075
Injection site erythema 15.62 9.95 111 63169 78086 79603022
Rhabdomyolysis 15.48 9.95 37 63243 103094 79578014
Cardio-respiratory arrest 15.46 9.95 40 63240 108470 79572638
Eye swelling 15.26 9.95 51 63229 26417 79654691
Oedema peripheral 15.21 9.95 283 62997 252005 79429103
Drug eruption 15.09 9.95 8 63272 43927 79637181
Bone cyst 15.05 9.95 16 63264 3417 79677691
Memory impairment 15.01 9.95 145 63135 111589 79569519
Diabetes mellitus 14.43 9.95 25 63255 78365 79602743
Laboratory test abnormal 14.39 9.95 52 63228 27996 79653112
Nasal congestion 14.34 9.95 107 63173 76445 79604663
Pulmonary arterial hypertension 14.06 9.95 52 63228 28314 79652794
Haematocrit decreased 14.03 9.95 90 63190 61222 79619886
Urinary tract infection 13.90 9.95 300 62980 274212 79406896
Hypoxia 13.88 9.95 134 63146 103109 79577999
Exposure during pregnancy 13.86 9.95 38 63242 101094 79580014
Dysgeusia 13.74 9.95 85 63195 57092 79624016
Asthma 13.59 9.95 58 63222 135037 79546071
Granulomatous liver disease 13.52 9.95 10 63270 1323 79679785
Blister 13.48 9.95 49 63231 119427 79561681
Shock 13.45 9.95 9 63271 43539 79637569
Psoriasis 13.41 9.95 119 63161 89468 79591640
Platelet count decreased 13.39 9.95 223 63057 194441 79486667
Prealbumin decreased 13.34 9.95 5 63275 160 79680948
Fibromyalgia 13.28 9.95 19 63261 64321 79616787
Irritable bowel syndrome 13.23 9.95 18 63262 62223 79618885
Hepatocellular injury 13.20 9.95 11 63269 47582 79633526
Pulmonary hypertension 13.19 9.95 74 63206 48006 79633102
Complication associated with device 13.16 9.95 37 63243 17459 79663649
Lymphopenia 13.04 9.95 4 63276 30553 79650555
Labelled drug-drug interaction medication error 12.98 9.95 3 63277 27647 79653461
Cardiac failure 12.95 9.95 71 63209 154771 79526337
Injection site haemorrhage 12.91 9.95 50 63230 27820 79653288
Fibrin D dimer increased 12.90 9.95 24 63256 8630 79672478
Respiratory arrest 12.89 9.95 16 63264 57534 79623574
Abdominal adhesions 12.83 9.95 15 63265 3558 79677550
Pneumocystis jirovecii pneumonia 12.60 9.95 5 63275 32503 79648605
Hypertension 12.51 9.95 186 63094 330806 79350302
Pain in extremity 12.46 9.95 378 62902 364160 79316948
Anxiety 12.39 9.95 271 63009 248241 79432867
Ill-defined disorder 12.13 9.95 21 63259 65854 79615254
Hiatus hernia strangulated 12.08 9.95 5 63275 209 79680899
Underdose 11.88 9.95 55 63225 33096 79648012
Accidental exposure to product 11.84 9.95 5 63275 31317 79649791
Cystic fibrosis 11.83 9.95 15 63265 3865 79677243
Product complaint 11.83 9.95 30 63250 13319 79667789
Rotator cuff syndrome 11.79 9.95 31 63249 14064 79667044
Cardiac arrest 11.76 9.95 84 63196 172012 79509096
Rheumatic fever 11.71 9.95 4 63276 28521 79652587
Vision blurred 11.66 9.95 132 63148 105766 79575342
Prescribed overdose 11.48 9.95 8 63272 37875 79643233
Influenza 11.45 9.95 155 63125 129451 79551657
Discomfort 11.41 9.95 56 63224 125561 79555547
Abdominal distension 11.36 9.95 145 63135 119505 79561603
Poisoning 11.36 9.95 3 63277 25269 79655839
Breast cancer 11.34 9.95 55 63225 33726 79647382
Thrombosis 11.23 9.95 109 63171 83991 79597117
Red blood cell sedimentation rate increased 11.13 9.95 12 63268 45930 79635178
Red blood cell count decreased 11.12 9.95 81 63199 57432 79623676
Altered state of consciousness 11.12 9.95 11 63269 43811 79637297
Anaphylactic reaction 11.08 9.95 32 63248 83711 79597397
Neurotoxicity 11.06 9.95 6 63274 32512 79648596
Rheumatoid arthritis 10.98 9.95 109 63171 208361 79472747
Heavy menstrual bleeding 10.90 9.95 30 63250 13981 79667127
Back pain 10.82 9.95 317 62963 303863 79377245
Intestinal dilatation 10.82 9.95 12 63268 2688 79678420
Vaginal haemorrhage 10.82 9.95 40 63240 21777 79659331
Chills 10.81 9.95 183 63097 160051 79521057
Vitamin A decreased 10.75 9.95 3 63277 36 79681072
Serotonin syndrome 10.64 9.95 12 63268 45015 79636093
Polyneuropathy 10.60 9.95 3 63277 24148 79656960
Dyspnoea 10.45 9.95 802 62478 856223 78824885
Insomnia 10.28 9.95 261 63019 244909 79436199
Abdominal hernia 10.22 9.95 17 63263 5599 79675509
Disease progression 10.15 9.95 204 63076 184158 79496950
Circulatory collapse 10.09 9.95 9 63271 37659 79643449
Sinus headache 10.09 9.95 16 63264 5064 79676044
Blood pressure systolic increased 10.08 9.95 24 63256 66962 79614146
Abdominal pain 10.05 9.95 391 62889 389178 79291930
Application site erythema 10.02 9.95 16 63264 5094 79676014
Acute kidney injury 10.01 9.95 325 62955 519079 79162029
Tremor 9.97 9.95 190 63090 169893 79511215

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin A, plain
ATC D10AD02 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Retinoids for topical use in acne
ATC R01AX02 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Other nasal preparations
ATC S01XA02 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA CS M0022788 Vitamin A
CHEBI has role CHEBI:24020 fat-soluble vitamins
CHEBI has role CHEBI:25212 metabolites
FDA EPC N0000175950 Vitamin A
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vitamin A deficiency indication 72000004
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Prevention of dental caries indication 426482000
Mineral Deficiency Prevention indication
Vitamin Deficiency Prevention indication
Diaper rash off-label use 91487003
Abetalipoproteinemia off-label use 190787008 DOID:1386
Skin irritation off-label use 367466007
Peptic ulcer contraindication 13200003 DOID:750
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Gastroenteritis contraindication 25374005 DOID:2326
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Hemosiderosis contraindication 39011001 DOID:12119
Hemolytic anemia contraindication 61261009 DOID:583
Hypervitaminosis A contraindication 64559002 DOID:9972
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication
Malabsorption States contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.62 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
11-cis retinol dehydrogenase Enzyme WOMBAT-PK
Retinol dehydrogenase 12 Enzyme WOMBAT-PK
Retinol dehydrogenase 13 Enzyme WOMBAT-PK
Retinol-binding protein 3 Surface antigen WOMBAT-PK
Retinol-binding protein 5 Cytosolic other WOMBAT-PK
Retinoid-binding protein 7 Cytosolic other WOMBAT-PK
Retinol-binding protein 4 Secreted Kd 6.74 CHEMBL
Retinol-binding protein 2 Cytosolic other WOMBAT-PK
Retinal dehydrogenase 2 Enzyme WOMBAT-PK
Retinal dehydrogenase 1 Enzyme WOMBAT-PK
Retinaldehyde-binding protein 1 Transporter WOMBAT-PK
Retinol-binding protein 1 Cytosolic other WOMBAT-PK
Amyloid beta A4 protein Unclassified IC50 6.75 CHEMBL
Nuclear receptor subfamily 2 group C member 2 Nuclear other AGONIST EC50 4.71 IUPHAR
Alpha-synuclein Transporter IC50 6.72 CHEMBL
Beta-lactoglobulin Unclassified Kd 7.44 CHEMBL

External reference:

IDSource
4021164 VUID
N0000148615 NUI
D06543 KEGG_DRUG
11103-57-4 SECONDARY_CAS_RN
4017648 VANDF
4021164 VANDF
4021715 VANDF
C0042839 UMLSCUI
CHEBI:50211 CHEBI
RTL PDB_CHEM_ID
CHEMBL986 ChEMBL_ID
CHEMBL1675 ChEMBL_ID
DB00162 DRUGBANK_ID
D014801 MESH_DESCRIPTOR_UI
445354 PUBCHEM_CID
4053 IUPHAR_LIGAND_ID
2243 INN_ID
G2SH0XKK91 UNII
11246 RXNORM
232172 MMSL
5678 MMSL
975 MMSL
d00402 MMSL
001000 NDDF
82156005 SNOMEDCT_US
82622003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 330 ug ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 6000 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 2700 [iU] ORAL Unapproved drug other 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 2700 [iU] ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1100 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 4000 [iU] ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 900 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 900 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1100 [iU] ORAL unapproved drug other 7 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 2500 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Budpak Vitamin A and D HUMAN OTC DRUG LABEL 2 27293-036 CREAM 181.80 [iU] TOPICAL OTC monograph not final 11 sections
Multivitamin with fluoride HUMAN PRESCRIPTION DRUG LABEL 11 50090-0356 TABLET, CHEWABLE 2500 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Multivitamin with fluoride HUMAN PRESCRIPTION DRUG LABEL 11 50090-0435 TABLET, CHEWABLE 2500 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 12 50090-4475 TABLET, CHEWABLE 750 ug ORAL unapproved drug other 10 sections
Multi Vitamin and Mineralvitamin HUMAN OTC DRUG LABEL 11 51220-2001 TABLET, CHEWABLE 3.50 mg ORAL unapproved drug other 16 sections
Vitamin A and D HUMAN OTC DRUG LABEL 2 52000-026 CREAM 181.80 [iU] TOPICAL OTC monograph not final 11 sections
Kimchi Vitaminchewable multivitamin HUMAN OTC DRUG LABEL 11 52102-1001 TABLET, CHEWABLE 0.68 mg ORAL unapproved drug other 4 sections
Multi-Vitamin Fluoride Drops HUMAN PRESCRIPTION DRUG LABEL 10 52959-593 SOLUTION 1500 [iU] ORAL Unapproved drug other 11 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 58657-163 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 58657-163 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 58657-164 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 58657-164 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 58657-165 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 58657-165 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
M-Natal Plus HUMAN PRESCRIPTION DRUG LABEL 14 58657-170 TABLET 4000 [iU] ORAL unapproved drug other 7 sections
M-Natal Plus HUMAN PRESCRIPTION DRUG LABEL 14 58657-170 TABLET 4000 [iU] ORAL unapproved drug other 7 sections
Tri-Vite Drops with Fluoride HUMAN PRESCRIPTION DRUG LABEL 4 58657-323 SOLUTION 1500 [iU] ORAL unapproved drug other 9 sections
Tri-Vite Drops with Fluoride HUMAN PRESCRIPTION DRUG LABEL 4 58657-323 SOLUTION 1500 [iU] ORAL unapproved drug other 9 sections
Tri-Vite Drops with Fluoride HUMAN PRESCRIPTION DRUG LABEL 4 58657-324 SOLUTION 1500 [iU] ORAL unapproved drug other 9 sections
Tri-Vite Drops with Fluoride HUMAN PRESCRIPTION DRUG LABEL 4 58657-324 SOLUTION 1500 [iU] ORAL unapproved drug other 9 sections