retinol indications/contra

Stem definitionDrug idCAS RN
retinol derivatives 2831 68-26-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vitamin A1
  • vitamin A
  • retinol
  • retinol (vit A)
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
  • Molecular weight: 286.46
  • Formula: C20H30O
  • CLOGP: 6.40
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -4.58
  • ROTB: 5

Drug dosage:

DoseUnitRoute
50 TU O
50 TU P
800 U N

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A11CA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin A, plain
ATC D10AD02 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Retinoids for topical use in acne
ATC R01AX02 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Other nasal preparations
ATC S01XA02 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA Chemical/Ingredient N0000006269 Vitamin A
MeSH PA D006133 Growth Substances
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Vitamin A deficiency indication 72000004
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Prevention of dental caries indication 426482000
Mineral Deficiency Prevention indication
Vitamin Deficiency Prevention indication
Peptic ulcer contraindication 13200003 DOID:750
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Gastroenteritis contraindication 25374005 DOID:2326
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:13404
Hemosiderosis contraindication 39011001 DOID:12119
Hemolytic anemia contraindication 61261009 DOID:583
Hypervitaminosis A contraindication 64559002 DOID:9972
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Kidney disease contraindication 90708001 DOID:2527
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication
Malabsorption States contraindication
Diaper rash off-label use 91487003
Abetalipoproteinemia off-label use 190787008 DOID:1386
Skin irritation off-label use 367466007

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.62 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Retinol-binding protein 4 Secreted Kd 6.74 CHEMBL
Retinaldehyde-binding protein 1 Unclassified WOMBAT-PK
Retinol-binding protein 3 Surface antigen WOMBAT-PK
Retinal dehydrogenase 1 Enzyme WOMBAT-PK
Retinal dehydrogenase 2 Enzyme WOMBAT-PK
Retinol-binding protein 2 Cytosolic other WOMBAT-PK
Retinoid-binding protein 7 Cytosolic other WOMBAT-PK
Retinol-binding protein 5 Cytosolic other WOMBAT-PK
Retinol dehydrogenase 13 Enzyme WOMBAT-PK
Retinol dehydrogenase 12 Enzyme WOMBAT-PK
11-cis retinol dehydrogenase Enzyme WOMBAT-PK
Retinol-binding protein 1 Cytosolic other WOMBAT-PK
Nuclear receptor subfamily 2 group C member 2 Unclassified AGONIST EC50 4.71 IUPHAR
Beta-lactoglobulin Unclassified Kd 7.44 CHEMBL

External reference:

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IDSource
DB00162 DRUGBANK_ID
4053 IUPHAR_LIGAND_ID
4021164 VUID
N0000148615 NUI
C0042839 UMLSCUI
D06543 KEGG_DRUG
CHEMBL986 ChEMBL_ID
445354 PUBCHEM_CID
4021164 VANDF
4017648 VANDF
N0000148615 NDFRT
N0000146027 NDFRT
N0000006269 NDFRT
975 MMSL
11246 RXNORM
82622003 SNOMEDCT_US
5678 MMSL
d00402 MMSL
001000 NDDF
232172 MMSL
82156005 SNOMEDCT_US
CHEBI:45479 CHEBI
G2SH0XKK91 UNII
2243 INN_ID
D014801 MESH_DESCRIPTOR_UI
RTL PDB_CHEM_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Vitafol HUMAN PRESCRIPTION DRUG LABEL 11 0642-0070 CAPSULE, GELATIN COATED 1100 [iU] ORAL unapproved drug other 6 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 9 0642-0072 CAPSULE 6000 [iU] ORAL UNAPPROVED DRUG OTHER 9 sections
Vitafol-OB Plus DHA HUMAN PRESCRIPTION DRUG LABEL 10 0642-0076 KIT 2700 [iU] None Unapproved drug other 10 sections
Vitafol OB HUMAN PRESCRIPTION DRUG LABEL 9 0642-0079 TABLET 2700 [iU] ORAL Unapproved drug other 11 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 12 0642-0092 CAPSULE, LIQUID FILLED 1100 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 12 0642-0096 KIT 1100 [iU] None UNAPPROVED DRUG OTHER 10 sections
Strovite Forte HUMAN PRESCRIPTION DRUG LABEL 11 0642-0204 TABLET, COATED 4000 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Strovite One HUMAN PRESCRIPTION DRUG LABEL 16 0642-0207 TABLET 3000 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 11 0642-3010 CAPSULE, GELATIN COATED 1100 [iU] ORAL unapproved drug other 6 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 12 0813-0202 TABLET 2500 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Multi-Vitamin HUMAN OTC DRUG LABEL 8 24451-008 LIQUID 2250 [iU] ORAL unapproved drug other 12 sections
Budpak Vitamin A and D HUMAN OTC DRUG LABEL 1 27293-036 CREAM 181.80 [iU] TOPICAL OTC monograph not final 11 sections
Prenatal Plus HUMAN PRESCRIPTION DRUG LABEL 13 42937-705 TABLET 4000 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Tri-Vitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 3 44946-1035 SOLUTION/ DROPS 1500 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Prenatal Plus Multivitamin Plus DHA MiniCaps HUMAN PRESCRIPTION DRUG LABEL 12 44946-2001 KIT 4000 [iU] None Unapproved drug other 8 sections
Multivitamin Drops with Fluoride HUMAN PRESCRIPTION DRUG LABEL 8 44946-2005 SOLUTION/ DROPS 1500 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Multivitamin Drops with Fluoride HUMAN PRESCRIPTION DRUG LABEL 9 44946-2006 SOLUTION/ DROPS 1500 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Multivitamin with fluoride HUMAN PRESCRIPTION DRUG LABEL 10 50090-0356 TABLET, CHEWABLE 2500 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Multivitamin with fluoride HUMAN PRESCRIPTION DRUG LABEL 10 50090-0435 TABLET, CHEWABLE 2500 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Multi Vitamin and Mineral HUMAN OTC DRUG LABEL 10 51220-2001 TABLET, CHEWABLE 3.50 mg ORAL unapproved drug other 8 sections
Prenatal Mega Antioxidant HUMAN OTC DRUG LABEL 11 51861-103 TABLET 3750 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Vitamin A and D HUMAN OTC DRUG LABEL 1 52000-026 CREAM 181.80 [iU] TOPICAL OTC monograph not final 11 sections
Kimchi Vitamin HUMAN OTC DRUG LABEL 11 52102-1001 TABLET, CHEWABLE 0.68 mg ORAL unapproved drug other 1 sections
PreQue 10 HUMAN PRESCRIPTION DRUG LABEL 16 52544-079 TABLET 1250 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Multi-Vitamin Fluoride Drops HUMAN PRESCRIPTION DRUG LABEL 9 52959-593 SOLUTION 1500 [iU] ORAL Unapproved drug other 11 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 12 59088-107 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 12 59088-108 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 9 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 12 59088-109 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multi-Vitamin With Fluoride HUMAN PRESCRIPTION DRUG LABEL 9 60429-616 TABLET, CHEWABLE 2500 [iU] ORAL Unapproved drug other 9 sections
Multi-Vitamin With Fluoride HUMAN PRESCRIPTION DRUG LABEL 9 60429-617 TABLET, CHEWABLE 2500 [iU] ORAL Unapproved drug other 9 sections