retinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
retinol derivatives	2831	68-26-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: vitamin A1 vitamin A retinol retinol (vit A)	Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. Molecular weight: 286.46 Formula: C20H30O CLOGP: 6.40 LIPINSKI: 1 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: -4.58 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

vitamin A1
vitamin A
retinol
retinol (vit A)

Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.

Molecular weight: 286.46
Formula: C20H30O
CLOGP: 6.40
LIPINSKI: 1
HAC: 1
HDO: 1
TPSA: 20.23
ALOGS: -4.58
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
50	TU	O
50	TU	P
800	U	N

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.04 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0 %	Benet LZ, Broccatelli F, Oprea TI

Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	135.76	10.33	3	51932	183723	63253364
Synovitis	124.52	10.33	7	51928	186911	63250176
Contraindicated product administered	121.36	10.33	17	51918	217631	63219456
Hand deformity	116.28	10.33	3	51932	159454	63277633
Systemic lupus erythematosus	108.21	10.33	20	51915	208898	63228189
Pneumonia aspiration	107.66	10.33	137	51798	34403	63402684
Completed suicide	95.35	10.33	6	51929	145667	63291420
Glossodynia	95.08	10.33	16	51919	178860	63258227
Product use issue	83.40	10.33	38	51897	220482	63216605
Maternal exposure during pregnancy	83.10	10.33	38	51897	220024	63217063
Anti-cyclic citrullinated peptide antibody positive	81.78	10.33	3	51932	116209	63320878
Pericarditis	81.60	10.33	7	51928	131572	63305515
Gastrooesophageal reflux disease	80.77	10.33	215	51720	95424	63341663
Product dose omission issue	75.56	10.33	385	51550	233928	63203159
Diarrhoea	74.89	10.33	903	51032	714463	62722624
Toxicity to various agents	74.55	10.33	56	51879	247194	63189893
Drug ineffective	74.38	10.33	526	51409	1044239	62392848
Blood magnesium increased	70.87	10.33	39	51896	2999	63434088
Pleural thickening	70.00	10.33	38	51897	2845	63434242
Wound	68.47	10.33	24	51911	163239	63273848
Presbyacusis	64.70	10.33	36	51899	2829	63434258
Infusion related reaction	62.69	10.33	65	51870	245456	63191631
Muscle spasms	62.29	10.33	273	51662	155877	63281210
Product use in unapproved indication	61.50	10.33	35	51900	179045	63258042
Pleural fibrosis	60.83	10.33	37	51898	3435	63433652
Duodenal ulcer perforation	55.86	10.33	4	51931	87205	63349882
Off label use	55.76	10.33	324	51611	674138	62762949
Deafness neurosensory	51.80	10.33	38	51897	4817	63432270
Arthropathy	49.56	10.33	72	51863	234720	63202367
Cyst	48.86	10.33	59	51876	14040	63423047
Unevaluable event	47.97	10.33	120	51815	51266	63385821
Device expulsion	47.76	10.33	95	51840	34827	63402260
Full blood count decreased	47.23	10.33	80	51855	25944	63411143
Fall	47.03	10.33	509	51426	391825	63045262
Lower respiratory tract infection	45.21	10.33	26	51909	132281	63304806
Therapeutic product effect decreased	45.08	10.33	55	51880	193132	63243955
Fatigue	43.58	10.33	990	50945	887038	62550049
Drug intolerance	42.65	10.33	121	51814	308540	63128547
Epigastric discomfort	42.63	10.33	39	51896	6741	63430346
Neuropathy peripheral	42.50	10.33	195	51740	113472	63323615
Somnolence	42.01	10.33	270	51665	178415	63258672
Helicobacter infection	41.81	10.33	12	51923	92773	63344314
Coma	41.12	10.33	131	51804	64233	63372854
Therapy cessation	39.44	10.33	81	51854	30376	63406711
Hepatic enzyme increased	38.93	10.33	66	51869	202262	63234825
Folliculitis	37.98	10.33	6	51929	70311	63366776
Psoriasis	36.93	10.33	155	51780	86802	63350285
Intentional overdose	36.48	10.33	8	51927	74144	63362943
Dry eye	35.77	10.33	93	51842	40668	63396419
Therapeutic product effect incomplete	35.55	10.33	30	51905	125026	63312061
Device dislocation	35.24	10.33	70	51865	25635	63411452
Intentional product use issue	33.59	10.33	33	51902	127859	63309228
Dizziness	33.00	10.33	514	51421	429411	63007676
Flatulence	32.34	10.33	81	51854	34621	63402466
Discomfort	31.82	10.33	55	51880	167319	63269768
Joint swelling	31.68	10.33	149	51786	327517	63109570
Constipation	30.78	10.33	300	51635	224643	63212444
Exposure during pregnancy	30.60	10.33	50	51885	155497	63281590
Deep vein thrombosis	30.02	10.33	142	51793	83658	63353429
Osteopenia	29.71	10.33	56	51879	19729	63417358
Drug hypersensitivity	29.61	10.33	142	51793	310545	63126542
Drug interaction	29.34	10.33	93	51842	229038	63208049
Asthenia	29.18	10.33	458	51477	383146	63053941
Infective pulmonary exacerbation of cystic fibrosis	29.10	10.33	36	51899	8781	63428306
Blood potassium increased	28.97	10.33	53	51882	18256	63418831
Liver injury	28.83	10.33	7	51928	60513	63376574
Feeling abnormal	28.81	10.33	214	51721	148178	63288909
Nausea	28.70	10.33	907	51028	853564	62583523
Treatment failure	28.23	10.33	77	51858	198966	63238121
Hypoaesthesia	27.83	10.33	234	51701	168159	63268928
C-reactive protein increased	27.81	10.33	22	51913	94685	63342402
Choanal stenosis	26.45	10.33	6	51929	27	63437060
General physical health deterioration	26.31	10.33	81	51854	201321	63235766
Alopecia	26.28	10.33	165	51770	337371	63099716
Pneumonia	25.73	10.33	520	51415	456247	62980840
Overdose	25.55	10.33	34	51901	115044	63322043
Laboratory test abnormal	25.27	10.33	63	51872	26849	63410238
Rheumatic fever	24.88	10.33	3	51932	43108	63393979
Blister	23.46	10.33	44	51891	129770	63307317
Haemoglobin decreased	23.42	10.33	201	51734	145284	63291803
Plasma cell myeloma	22.85	10.33	73	51862	35832	63401255
Bone cyst	22.61	10.33	17	51918	2237	63434850
Memory impairment	22.34	10.33	154	51781	104104	63332983
Injection site reaction	22.30	10.33	101	51834	58423	63378664
Granulomatous liver disease	20.99	10.33	11	51924	767	63436320
Irritable bowel syndrome	20.80	10.33	22	51913	82390	63354697
Suicide attempt	20.76	10.33	12	51923	60906	63376181
Injection site pain	20.72	10.33	179	51756	129621	63307466
Ill-defined disorder	20.44	10.33	22	51913	81733	63355354
Rheumatoid arthritis	20.30	10.33	123	51812	253696	63183391
Skin lesion	20.05	10.33	63	51872	30658	63406429
Pelvic pain	19.97	10.33	38	51897	13481	63423606
Swelling	19.23	10.33	139	51796	275239	63161848
Headache	18.58	10.33	662	51273	632579	62804508
Fluid retention	18.44	10.33	97	51838	59589	63377498
Dry skin	17.95	10.33	93	51842	56794	63380293
Blood potassium decreased	17.90	10.33	75	51860	41951	63395136
Aorta hypoplasia	17.50	10.33	6	51929	143	63436944
Osteochondritis	16.67	10.33	4	51931	24	63437063
Osteosclerosis	16.38	10.33	18	51917	3870	63433217
Enterobacter infection	16.37	10.33	14	51921	2213	63434874
Dehydration	16.34	10.33	215	51720	173139	63263948
Hip fracture	16.16	10.33	57	51878	29417	63407670
Underdose	15.84	10.33	54	51881	27402	63409685
Abdominal discomfort	15.81	10.33	177	51758	320708	63116379
Eye swelling	15.56	10.33	49	51886	23869	63413218
Anxiety	15.11	10.33	256	51679	217285	63219802
Influenza like illness	15.08	10.33	100	51835	66724	63370363
Injection site erythema	15.04	10.33	118	51817	83056	63354031
Back pain	14.92	10.33	301	51634	263844	63173243
Dyspnoea exertional	14.69	10.33	92	51843	60210	63376877
Hepatic function abnormal	14.66	10.33	6	51929	37136	63399951
Body height decreased	14.48	10.33	28	51907	10050	63427037
COVID-19	14.40	10.33	46	51889	113057	63324030
Tooth disorder	14.21	10.33	53	51882	28104	63408983
Injection site haemorrhage	14.19	10.33	48	51887	24266	63412821
Hospitalisation	13.92	10.33	118	51817	84963	63352124
Weight decreased	13.88	10.33	310	51625	276488	63160599
Vision blurred	13.75	10.33	125	51810	91799	63345288
Hot flush	13.70	10.33	80	51855	51079	63386008
Depression	13.56	10.33	231	51704	196261	63240826
Hepatocellular injury	13.37	10.33	3	51932	27378	63409709
Paraesthesia	13.29	10.33	191	51744	156775	63280312
Pain in extremity	13.26	10.33	360	51575	331126	63105961
Oedema peripheral	13.15	10.33	223	51712	189288	63247799
Intestinal dilatation	13.02	10.33	11	51924	1711	63435376
Tremor	12.87	10.33	165	51770	132074	63305013
International normalised ratio decreased	12.69	10.33	17	51918	4484	63432603
Abdominal distension	12.56	10.33	117	51818	86498	63350589
Nasal congestion	12.34	10.33	94	51841	65566	63371521
Urinary tract infection	12.21	10.33	293	51642	264391	63172696
Tracheo-oesophageal fistula	12.18	10.33	7	51928	585	63436502
Plasma cell myeloma recurrent	12.05	10.33	14	51921	3199	63433888
Pollakiuria	12.01	10.33	50	51885	27887	63409200
Pulmonary arterial hypertension	11.82	10.33	43	51892	22534	63414553
Agranulocytosis	11.79	10.33	3	51932	25131	63411956
Respiratory arrest	11.75	10.33	6	51929	32639	63404448
Asthma	11.73	10.33	59	51876	127502	63309585
Hip arthroplasty	11.71	10.33	13	51922	47633	63389454
Chills	11.69	10.33	143	51792	113235	63323852
White blood cell count decreased	11.67	10.33	169	51766	138935	63298152
Vaginal haemorrhage	11.66	10.33	49	51886	27438	63409649
Hypervolaemia	11.55	10.33	50	51885	28363	63408724
Pulmonary embolism	11.53	10.33	146	51789	116538	63320549
Hiatus hernia strangulated	11.49	10.33	5	51930	230	63436857
Hypoxia	11.46	10.33	86	51849	59706	63377381
Bone hypertrophy	11.45	10.33	6	51929	418	63436669
Anaphylactic reaction	11.42	10.33	23	51912	66077	63371010
Multiple organ dysfunction syndrome	11.38	10.33	18	51917	56734	63380353
Skin discolouration	11.35	10.33	61	51874	37767	63399320
Depressed level of consciousness	11.25	10.33	21	51914	62057	63375030
Administration site swelling	11.24	10.33	9	51926	1298	63435789
Balance disorder	11.23	10.33	112	51823	84310	63352777
Dysgeusia	11.21	10.33	71	51864	46639	63390448
Red blood cell sedimentation rate increased	10.81	10.33	12	51923	43970	63393117
Insomnia	10.76	10.33	241	51694	215011	63222076
Anaphylactic shock	10.75	10.33	3	51932	23630	63413457
Drug eruption	10.74	10.33	5	51930	28689	63408398
Intentional product misuse	10.69	10.33	21	51914	60896	63376191
Cholelithiasis	10.69	10.33	67	51868	43858	63393229
Type 2 diabetes mellitus	10.38	10.33	23	51912	63845	63373242
Failure to thrive	10.35	10.33	20	51915	7178	63429909

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	78.38	11.36	137	28079	419387	34509328
Drug abuse	61.23	11.36	5	28211	99091	34829624
Fatigue	58.26	11.36	503	27713	370150	34558565
Completed suicide	57.85	11.36	6	28210	98162	34830553
Product use in unapproved indication	45.40	11.36	19	28197	117480	34811235
Toxicity to various agents	43.42	11.36	59	28157	200303	34728412
Product dose omission issue	43.04	11.36	201	28015	119510	34809205
Respiratory tract infection bacterial	42.20	11.36	23	28193	1759	34926956
Drug interaction	40.94	11.36	75	28141	225871	34702844
Plasma cell myeloma	38.89	11.36	97	28119	41940	34886775
Respiratory tract infection viral	37.30	11.36	24	28192	2493	34926222
Laboratory test abnormal	36.72	11.36	62	28154	20329	34908386
Full blood count decreased	35.27	11.36	57	28159	18031	34910684
White blood cell count decreased	34.84	11.36	161	28055	95284	34833431
Diarrhoea	30.07	11.36	461	27755	389451	34539264
Fall	28.97	11.36	270	27946	202615	34726100
Infective pulmonary exacerbation of cystic fibrosis	28.17	11.36	31	28185	6770	34921945
Adverse drug reaction	27.44	11.36	68	28148	29274	34899441
Asthenia	26.77	11.36	309	27907	244942	34683773
Viral infection	25.85	11.36	49	28167	17574	34911141
Influenza	25.40	11.36	93	28123	49573	34879142
General physical health deterioration	24.62	11.36	41	28175	128228	34800487
Sinusitis	23.29	11.36	80	28136	41322	34887393
Interstitial lung disease	21.53	11.36	13	28203	65269	34863446
Neuropathy peripheral	21.10	11.36	127	28089	83136	34845579
Psoriasis	20.97	11.36	74	28142	38738	34889977
Drug ineffective	20.65	11.36	253	27963	456498	34472217
Rash	20.13	11.36	271	27945	222481	34706234
Muscle spasms	20.03	11.36	116	28100	74885	34853830
Intentional product misuse	19.95	11.36	6	28210	45605	34883110
Dizziness	19.81	11.36	266	27950	218255	34710460
Platelet count decreased	18.93	11.36	163	28053	119554	34809161
Haemoglobin decreased	18.87	11.36	164	28052	120608	34808107
Fibrin D dimer increased	18.72	11.36	20	28196	4224	34924491
Flatulence	18.64	11.36	48	28168	21150	34907565
Hypervitaminosis A	18.27	11.36	4	28212	15	34928700
Peripheral swelling	17.06	11.36	113	28103	76428	34852287
Thrombosis	16.85	11.36	83	28133	50375	34878340
Foetal exposure during pregnancy	16.68	11.36	5	28211	38096	34890619
Overdose	16.65	11.36	30	28186	91029	34837686
Hepatic function abnormal	15.83	11.36	8	28208	44355	34884360
Pneumonia	15.68	11.36	393	27823	362234	34566481
Febrile neutropenia	15.15	11.36	58	28158	136791	34791924
Multiple organ dysfunction syndrome	15.13	11.36	24	28192	76542	34852173
Constipation	14.64	11.36	172	28044	136810	34791905
Weight decreased	14.50	11.36	211	28005	176090	34752625
Treatment failure	14.44	11.36	10	28206	46687	34882028
Dehydration	14.24	11.36	164	28052	129805	34798910
Coma	13.83	11.36	10	28206	45668	34883047
Leukopenia	13.09	11.36	19	28197	62837	34865878
Prealbumin decreased	12.52	11.36	4	28212	77	34928638
Small intestinal obstruction	12.39	11.36	33	28183	14833	34913882
Headache	12.37	11.36	229	27987	200406	34728309
Cardiac disorder	12.36	11.36	68	28148	43058	34885657
Eye infection	12.29	11.36	15	28201	3658	34925057
Memory impairment	12.22	11.36	68	28148	43250	34885465
Blood testosterone decreased	11.76	11.36	16	28200	4341	34924374
Balance disorder	11.59	11.36	64	28152	40590	34888125
Hypoaesthesia	11.52	11.36	87	28129	61357	34867358

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	149.83	9.95	12	63268	245755	79435353
Toxicity to various agents	117.87	9.95	97	63183	421443	79259665
Drug abuse	107.97	9.95	5	63275	162686	79518422
Off label use	104.61	9.95	370	62910	906845	78774263
Synovitis	95.76	9.95	6	63274	150728	79530380
Product use in unapproved indication	93.17	9.95	41	63239	250318	79430790
Product dose omission issue	84.10	9.95	404	62876	247133	79433975
Drug ineffective	78.41	9.95	520	62760	1080393	78600715
Gastrooesophageal reflux disease	77.08	9.95	219	63061	104027	79577081
Contraindicated product administered	74.19	9.95	17	63263	157521	79523587
Drug interaction	69.93	9.95	140	63140	415043	79266065
Hand deformity	66.41	9.95	4	63276	103915	79577193
Pemphigus	66.25	9.95	3	63277	99579	79581529
Pneumonia aspiration	63.08	9.95	154	63126	66813	79614295
Device expulsion	62.14	9.95	89	63191	25772	79655336
Fall	60.14	9.95	621	62659	487008	79194100
Infective pulmonary exacerbation of cystic fibrosis	60.13	9.95	62	63218	12789	79668319
Pleural thickening	58.99	9.95	34	63246	2948	79678160
Presbyacusis	57.12	9.95	32	63248	2628	79678480
Fatigue	56.98	9.95	1044	62236	928683	78752425
Blood magnesium increased	56.42	9.95	35	63245	3471	79677637
Diarrhoea	54.03	9.95	989	62291	879500	78801608
Anti-cyclic citrullinated peptide antibody positive	53.74	9.95	3	63277	83140	79597968
Muscle spasms	53.50	9.95	277	63003	174453	79506655
Systemic lupus erythematosus	53.32	9.95	15	63265	121134	79559974
Intentional overdose	52.83	9.95	10	63270	105950	79575158
Product use issue	48.50	9.95	57	63223	209765	79471343
Pleural fibrosis	46.23	9.95	33	63247	4134	79676974
General physical health deterioration	46.13	9.95	93	63187	275145	79405963
Dizziness	46.11	9.95	628	62652	525813	79155295
Asthenia	45.06	9.95	611	62669	511078	79170030
Infusion related reaction	43.75	9.95	72	63208	230165	79450943
Plasma cell myeloma	43.43	9.95	116	63164	53143	79627965
Lower respiratory tract infection	42.30	9.95	25	63255	129195	79551913
Therapy cessation	41.53	9.95	92	63188	37470	79643638
Glossodynia	39.89	9.95	16	63264	103321	79577787
Respiratory tract infection bacterial	39.28	9.95	23	63257	2054	79679054
Epigastric discomfort	38.58	9.95	39	63241	7857	79673251
Helicobacter infection	38.32	9.95	5	63275	69699	79611409
Full blood count decreased	38.28	9.95	73	63207	26746	79654362
Intentional product misuse	37.95	9.95	14	63266	95151	79585957
Overdose	37.48	9.95	55	63225	184151	79496957
Maternal exposure during pregnancy	37.37	9.95	32	63248	136506	79544602
Pericarditis	37.30	9.95	18	63262	104218	79576890
Therapeutic product effect incomplete	36.61	9.95	35	63245	141610	79539498
Deep vein thrombosis	35.82	9.95	190	63090	120729	79560379
Deafness neurosensory	35.42	9.95	35	63245	6863	79674245
Haemoglobin decreased	35.40	9.95	299	62981	221820	79459288
Cyst	35.27	9.95	49	63231	13791	79667317
Dehydration	33.87	9.95	323	62957	247864	79433244
Device dislocation	33.81	9.95	68	63212	25902	79655206
Duodenal ulcer perforation	33.54	9.95	6	63274	66205	79614903
Drug intolerance	32.10	9.95	105	63175	264014	79417094
Somnolence	31.12	9.95	308	62972	238673	79442435
Osteopenia	30.02	9.95	53	63227	18311	79662797
Flatulence	29.86	9.95	88	63192	42636	79638472
Intentional product use issue	29.42	9.95	47	63233	152065	79529043
Respiratory tract infection viral	28.41	9.95	25	63255	4234	79676874
Fluid retention	28.19	9.95	120	63160	69689	79611419
Drug hypersensitivity	27.34	9.95	133	63147	298783	79382325
Hepatic enzyme increased	27.05	9.95	66	63214	182544	79498564
Dry eye	26.71	9.95	77	63203	36854	79644254
Unevaluable event	25.99	9.95	100	63180	55485	79625623
Hypervitaminosis A	25.79	9.95	6	63274	32	79681076
Nausea	25.18	9.95	962	62318	956234	78724874
Hospitalisation	25.18	9.95	144	63136	94092	79587016
Therapeutic response decreased	24.76	9.95	11	63269	66842	79614266
Interstitial lung disease	24.52	9.95	32	63248	112568	79568540
Joint swelling	24.38	9.95	132	63148	288514	79392594
Feeling abnormal	24.14	9.95	212	63068	158987	79522121
Hepatic function abnormal	24.13	9.95	14	63266	73093	79608015
Blood potassium increased	24.10	9.95	64	63216	29211	79651897
Folliculitis	24.10	9.95	7	63273	55373	79625735
Pneumonia	23.58	9.95	688	62592	659558	79021550
Wound	23.32	9.95	35	63245	116144	79564964
Suicide attempt	23.22	9.95	19	63261	82913	79598195
Depressed level of consciousness	22.59	9.95	26	63254	96626	79584482
Hospice care	22.59	9.95	34	63246	10290	79670818
Hip fracture	22.11	9.95	64	63216	30697	79650411
Myelosuppression	21.88	9.95	3	63277	40293	79640815
Injection site pain	21.85	9.95	177	63103	129661	79551447
Small intestinal obstruction	21.83	9.95	59	63221	27213	79653895
Hypervolaemia	21.79	9.95	79	63201	42611	79638497
Pelvic pain	21.08	9.95	38	63242	13343	79667765
Multiple organ dysfunction syndrome	20.67	9.95	40	63240	120206	79560902
Treatment failure	20.55	9.95	68	63212	170418	79510690
Neuropathy peripheral	20.31	9.95	186	63094	141119	79539989
Osteosclerosis	20.11	9.95	20	63260	3951	79677157
Dyspnoea exertional	20.04	9.95	128	63152	86945	79594163
Hypoaesthesia	19.97	9.95	224	63056	179128	79501980
Arthropathy	19.76	9.95	73	63207	177038	79504070
C-reactive protein increased	19.61	9.95	46	63234	128981	79552127
Weight decreased	19.59	9.95	393	62887	354805	79326303
Blood potassium decreased	19.59	9.95	81	63199	46431	79634677
Influenza like illness	19.43	9.95	110	63170	71597	79609511
Eosinophilia	19.24	9.95	6	63274	45339	79635769
Drug resistance	18.99	9.95	5	63275	42208	79638900
Viral infection	18.98	9.95	76	63204	42940	79638168
Multiple sclerosis relapse	18.79	9.95	80	63200	46453	79634655
Pulmonary embolism	18.49	9.95	213	63067	171441	79509667
Depression	18.25	9.95	257	63023	216533	79464575
Febrile neutropenia	18.22	9.95	108	63172	230891	79450217
White blood cell count decreased	17.82	9.95	228	63052	188060	79493048
Mental status changes	17.67	9.95	102	63178	66857	79614251
Injection site reaction	17.55	9.95	88	63192	54697	79626411
Cytomegalovirus infection	17.47	9.95	6	63274	42638	79638470
Constipation	17.24	9.95	318	62962	282732	79398376
Cholestasis	17.16	9.95	10	63270	52099	79629009
Headache	17.12	9.95	657	62623	653115	79027993
Liver injury	17.09	9.95	12	63268	56602	79624506
Therapeutic product effect decreased	16.71	9.95	70	63210	163793	79517315
Leukopenia	16.56	9.95	43	63237	116470	79564638
COVID-19	16.30	9.95	67	63213	157607	79523501
Coma	16.28	9.95	136	63144	100513	79580595
Osteochondritis	15.69	9.95	4	63276	33	79681075
Injection site erythema	15.62	9.95	111	63169	78086	79603022
Rhabdomyolysis	15.48	9.95	37	63243	103094	79578014
Cardio-respiratory arrest	15.46	9.95	40	63240	108470	79572638
Eye swelling	15.26	9.95	51	63229	26417	79654691
Oedema peripheral	15.21	9.95	283	62997	252005	79429103
Drug eruption	15.09	9.95	8	63272	43927	79637181
Bone cyst	15.05	9.95	16	63264	3417	79677691
Memory impairment	15.01	9.95	145	63135	111589	79569519
Diabetes mellitus	14.43	9.95	25	63255	78365	79602743
Laboratory test abnormal	14.39	9.95	52	63228	27996	79653112
Nasal congestion	14.34	9.95	107	63173	76445	79604663
Pulmonary arterial hypertension	14.06	9.95	52	63228	28314	79652794
Haematocrit decreased	14.03	9.95	90	63190	61222	79619886
Urinary tract infection	13.90	9.95	300	62980	274212	79406896
Hypoxia	13.88	9.95	134	63146	103109	79577999
Exposure during pregnancy	13.86	9.95	38	63242	101094	79580014
Dysgeusia	13.74	9.95	85	63195	57092	79624016
Asthma	13.59	9.95	58	63222	135037	79546071
Granulomatous liver disease	13.52	9.95	10	63270	1323	79679785
Blister	13.48	9.95	49	63231	119427	79561681
Shock	13.45	9.95	9	63271	43539	79637569
Psoriasis	13.41	9.95	119	63161	89468	79591640
Platelet count decreased	13.39	9.95	223	63057	194441	79486667
Prealbumin decreased	13.34	9.95	5	63275	160	79680948
Fibromyalgia	13.28	9.95	19	63261	64321	79616787
Irritable bowel syndrome	13.23	9.95	18	63262	62223	79618885
Hepatocellular injury	13.20	9.95	11	63269	47582	79633526
Pulmonary hypertension	13.19	9.95	74	63206	48006	79633102
Complication associated with device	13.16	9.95	37	63243	17459	79663649
Lymphopenia	13.04	9.95	4	63276	30553	79650555
Labelled drug-drug interaction medication error	12.98	9.95	3	63277	27647	79653461
Cardiac failure	12.95	9.95	71	63209	154771	79526337
Injection site haemorrhage	12.91	9.95	50	63230	27820	79653288
Fibrin D dimer increased	12.90	9.95	24	63256	8630	79672478
Respiratory arrest	12.89	9.95	16	63264	57534	79623574
Abdominal adhesions	12.83	9.95	15	63265	3558	79677550
Pneumocystis jirovecii pneumonia	12.60	9.95	5	63275	32503	79648605
Hypertension	12.51	9.95	186	63094	330806	79350302
Pain in extremity	12.46	9.95	378	62902	364160	79316948
Anxiety	12.39	9.95	271	63009	248241	79432867
Ill-defined disorder	12.13	9.95	21	63259	65854	79615254
Hiatus hernia strangulated	12.08	9.95	5	63275	209	79680899
Underdose	11.88	9.95	55	63225	33096	79648012
Accidental exposure to product	11.84	9.95	5	63275	31317	79649791
Cystic fibrosis	11.83	9.95	15	63265	3865	79677243
Product complaint	11.83	9.95	30	63250	13319	79667789
Rotator cuff syndrome	11.79	9.95	31	63249	14064	79667044
Cardiac arrest	11.76	9.95	84	63196	172012	79509096
Rheumatic fever	11.71	9.95	4	63276	28521	79652587
Vision blurred	11.66	9.95	132	63148	105766	79575342
Prescribed overdose	11.48	9.95	8	63272	37875	79643233
Influenza	11.45	9.95	155	63125	129451	79551657
Discomfort	11.41	9.95	56	63224	125561	79555547
Abdominal distension	11.36	9.95	145	63135	119505	79561603
Poisoning	11.36	9.95	3	63277	25269	79655839
Breast cancer	11.34	9.95	55	63225	33726	79647382
Thrombosis	11.23	9.95	109	63171	83991	79597117
Red blood cell sedimentation rate increased	11.13	9.95	12	63268	45930	79635178
Red blood cell count decreased	11.12	9.95	81	63199	57432	79623676
Altered state of consciousness	11.12	9.95	11	63269	43811	79637297
Anaphylactic reaction	11.08	9.95	32	63248	83711	79597397
Neurotoxicity	11.06	9.95	6	63274	32512	79648596
Rheumatoid arthritis	10.98	9.95	109	63171	208361	79472747
Heavy menstrual bleeding	10.90	9.95	30	63250	13981	79667127
Back pain	10.82	9.95	317	62963	303863	79377245
Intestinal dilatation	10.82	9.95	12	63268	2688	79678420
Vaginal haemorrhage	10.82	9.95	40	63240	21777	79659331
Chills	10.81	9.95	183	63097	160051	79521057
Vitamin A decreased	10.75	9.95	3	63277	36	79681072
Serotonin syndrome	10.64	9.95	12	63268	45015	79636093
Polyneuropathy	10.60	9.95	3	63277	24148	79656960
Dyspnoea	10.45	9.95	802	62478	856223	78824885
Insomnia	10.28	9.95	261	63019	244909	79436199
Abdominal hernia	10.22	9.95	17	63263	5599	79675509
Disease progression	10.15	9.95	204	63076	184158	79496950
Circulatory collapse	10.09	9.95	9	63271	37659	79643449
Sinus headache	10.09	9.95	16	63264	5064	79676044
Blood pressure systolic increased	10.08	9.95	24	63256	66962	79614146
Abdominal pain	10.05	9.95	391	62889	389178	79291930
Application site erythema	10.02	9.95	16	63264	5094	79676014
Acute kidney injury	10.01	9.95	325	62955	519079	79162029
Tremor	9.97	9.95	190	63090	169893	79511215

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11CA01	ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO Vitamin A, plain
ATC	D10AD02	DERMATOLOGICALS ANTI-ACNE PREPARATIONS ANTI-ACNE PREPARATIONS FOR TOPICAL USE Retinoids for topical use in acne
ATC	R01AX02	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Other nasal preparations
ATC	S01XA02	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
FDA CS	M0022788	Vitamin A
CHEBI has role	CHEBI:24020	fat-soluble vitamins
CHEBI has role	CHEBI:25212	metabolites
FDA EPC	N0000175950	Vitamin A
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
MeSH PA	D018977	Micronutrients
MeSH PA	D014815	Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Vitamin A deficiency	indication	72000004
Vitamin deficiency	indication	85670002
Mineral deficiency	indication	111379007
Prevention of dental caries	indication	426482000
Mineral Deficiency Prevention	indication
Vitamin Deficiency Prevention	indication
Diaper rash	off-label use	91487003
Abetalipoproteinemia	off-label use	190787008	DOID:1386
Skin irritation	off-label use	367466007
Peptic ulcer	contraindication	13200003	DOID:750
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Hyperphosphatemia	contraindication	20165001	DOID:0050459
Gastroenteritis	contraindication	25374005	DOID:2326
Hypervitaminosis D	contraindication	27712000	DOID:9971
Sarcoidosis	contraindication	31541009	DOID:11335
Hemosiderosis	contraindication	39011001	DOID:12119
Hemolytic anemia	contraindication	61261009	DOID:583
Hypervitaminosis A	contraindication	64559002	DOID:9972
Ulcerative colitis	contraindication	64766004	DOID:8577
Hypercalcemia	contraindication	66931009	DOID:12678
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
Diverticular disease	contraindication	397881000
Hemochromatosis	contraindication	399187006	DOID:2352
Repeated Blood Transfusions	contraindication
Malabsorption States	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.62	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
11-cis retinol dehydrogenase	Enzyme	Q92781	RDH1_HUMAN				WOMBAT-PK
Retinol dehydrogenase 12	Enzyme	Q96NR8	RDH12_HUMAN				WOMBAT-PK
Retinol dehydrogenase 13	Enzyme	Q8NBN7	RDH13_HUMAN				WOMBAT-PK
Retinol-binding protein 3	Surface antigen	P10745	RET3_HUMAN				WOMBAT-PK
Retinol-binding protein 5	Cytosolic other	P82980	RET5_HUMAN				WOMBAT-PK
Retinoid-binding protein 7	Cytosolic other	Q96R05	RET7_HUMAN				WOMBAT-PK
Retinol-binding protein 4	Secreted	P02753	RET4_HUMAN		Kd	6.74	CHEMBL
Retinol-binding protein 2	Cytosolic other	P50120	RET2_HUMAN				WOMBAT-PK
Retinal dehydrogenase 2	Enzyme	O94788	AL1A2_HUMAN				WOMBAT-PK
Retinal dehydrogenase 1	Enzyme	P00352	AL1A1_HUMAN				WOMBAT-PK
Retinaldehyde-binding protein 1	Transporter	P12271	RLBP1_HUMAN				WOMBAT-PK
Retinol-binding protein 1	Cytosolic other	P09455	RET1_HUMAN				WOMBAT-PK
Amyloid beta A4 protein	Unclassified	P05067	A4_HUMAN		IC50	6.75	CHEMBL
Nuclear receptor subfamily 2 group C member 2	Nuclear other	P49116	NR2C2_HUMAN	AGONIST	EC50	4.71	IUPHAR
Alpha-synuclein	Transporter	P37840	SYUA_HUMAN		IC50	6.72	CHEMBL
Beta-lactoglobulin	Unclassified		LACB_BOVIN		Kd	7.44	CHEMBL

External reference:

ID	Source
4021164	VUID
N0000148615	NUI
D06543	KEGG_DRUG
11103-57-4	SECONDARY_CAS_RN
4017648	VANDF
4021164	VANDF
4021715	VANDF
C0042839	UMLSCUI
CHEBI:50211	CHEBI
RTL	PDB_CHEM_ID
CHEMBL986	ChEMBL_ID
CHEMBL1675	ChEMBL_ID
DB00162	DRUGBANK_ID
D014801	MESH_DESCRIPTOR_UI
445354	PUBCHEM_CID
4053	IUPHAR_LIGAND_ID
2243	INN_ID
G2SH0XKK91	UNII
11246	RXNORM
232172	MMSL
5678	MMSL
975	MMSL
d00402	MMSL
001000	NDDF
82156005	SNOMEDCT_US
82622003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
VitafolOne	HUMAN PRESCRIPTION DRUG LABEL	16	0642-0070	CAPSULE, GELATIN COATED	330 ug	ORAL	unapproved drug other	14 sections
Vitafol Caplet	HUMAN PRESCRIPTION DRUG LABEL	12	0642-0072	CAPSULE	6000 [iU]	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol OB Caplet	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0079	TABLET	2700 [iU]	ORAL	Unapproved drug other	14 sections
Vitafol OB Caplet	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0079	TABLET	2700 [iU]	ORAL	Unapproved drug other	14 sections
Vitafol Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0092	CAPSULE, LIQUID FILLED	1100 [iU]	ORAL	UNAPPROVED DRUG OTHER	13 sections
Strovite Forte Caplet	HUMAN PRESCRIPTION DRUG LABEL	19	0642-0204	TABLET, COATED	4000 [iU]	ORAL	UNAPPROVED DRUG OTHER	15 sections
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	900 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	900 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
Reaphirm Plant Source DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0642-3010	CAPSULE, GELATIN COATED	1100 [iU]	ORAL	unapproved drug other	7 sections
O-Cal Prenatal Vitamin	HUMAN PRESCRIPTION DRUG LABEL	16	0813-0202	TABLET	2500 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Budpak Vitamin A and D	HUMAN OTC DRUG LABEL	2	27293-036	CREAM	181.80 [iU]	TOPICAL	OTC monograph not final	11 sections
Multivitamin with fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	50090-0356	TABLET, CHEWABLE	2500 [iU]	ORAL	UNAPPROVED DRUG OTHER	8 sections
Multivitamin with fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	50090-0435	TABLET, CHEWABLE	2500 [iU]	ORAL	UNAPPROVED DRUG OTHER	8 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	12	50090-4475	TABLET, CHEWABLE	750 ug	ORAL	unapproved drug other	10 sections
Multi Vitamin and Mineralvitamin	HUMAN OTC DRUG LABEL	11	51220-2001	TABLET, CHEWABLE	3.50 mg	ORAL	unapproved drug other	16 sections
Vitamin A and D	HUMAN OTC DRUG LABEL	2	52000-026	CREAM	181.80 [iU]	TOPICAL	OTC monograph not final	11 sections
Kimchi Vitaminchewable multivitamin	HUMAN OTC DRUG LABEL	11	52102-1001	TABLET, CHEWABLE	0.68 mg	ORAL	unapproved drug other	4 sections
Multi-Vitamin Fluoride Drops	HUMAN PRESCRIPTION DRUG LABEL	10	52959-593	SOLUTION	1500 [iU]	ORAL	Unapproved drug other	11 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-163	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-163	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-164	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-164	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-165	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-165	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
M-Natal Plus	HUMAN PRESCRIPTION DRUG LABEL	14	58657-170	TABLET	4000 [iU]	ORAL	unapproved drug other	7 sections
M-Natal Plus	HUMAN PRESCRIPTION DRUG LABEL	14	58657-170	TABLET	4000 [iU]	ORAL	unapproved drug other	7 sections
Tri-Vite Drops with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	4	58657-323	SOLUTION	1500 [iU]	ORAL	unapproved drug other	9 sections
Tri-Vite Drops with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	4	58657-323	SOLUTION	1500 [iU]	ORAL	unapproved drug other	9 sections
Tri-Vite Drops with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	4	58657-324	SOLUTION	1500 [iU]	ORAL	unapproved drug other	9 sections
Tri-Vite Drops with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	4	58657-324	SOLUTION	1500 [iU]	ORAL	unapproved drug other	9 sections