balofloxacin indications/contra

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 283 127294-70-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • balofloxacin hydrate
  • balofloxacin
  • Q-Roxin
showed potent bactericidal activity & inhibited the supercoiling activity of DNA gyrase of S. aureus, E. coli, & P aeruginosa; structure given in first source
  • Molecular weight: 389.43
  • Formula: C20H24FN3O4
  • CLOGP: -0.36
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 82.11
  • ALOGS: -3.09
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 2001 Korean Food and Drug Administration (KFDA) CHOONGWAE

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.23 acidic
pKa2 8.47 Basic
pKa3 2.92 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
D02463 KEGG_DRUG
010872 NDDF
65958 PUBCHEM_CID
CHEMBL1210954 ChEMBL_ID
C077155 MESH_SUPPLEMENTAL_RECORD_UI
Q022B63JPM UNII
7236 INN_ID
CHEBI:34553 CHEBI

Pharmaceutical products:

None