vinburnine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
vinca alkaloids	2824	4880-88-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

vinburnine
vincamone
(-)-Vincamone
(-)-cis-Eburnamonine
l-Eburnamonine

Molecular weight: 294.40
Formula: C19H22N2O
CLOGP: 3.70
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 25.24
ALOGS: -3.23
ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C04AX17	CARDIOVASCULAR SYSTEM PERIPHERAL VASODILATORS PERIPHERAL VASODILATORS Other peripheral vasodilators
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D014665	Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.88	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN	ALLOSTERIC MODULATOR	Kd	5.10		IUPHAR
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN	ALLOSTERIC MODULATOR	Kd	4.20		IUPHAR
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN	ALLOSTERIC MODULATOR	Kd	5.20		IUPHAR
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN	ALLOSTERIC MODULATOR	Kd	4.60		IUPHAR

External reference:

ID	Source
D08676	KEGG_DRUG
C0148398	UMLSCUI
CHEBI:4740	CHEBI
CHEMBL1892145	ChEMBL_ID
DB13793	DRUGBANK_ID
C016422	MESH_SUPPLEMENTAL_RECORD_UI
71203	PUBCHEM_CID
345	IUPHAR_LIGAND_ID
4976	INN_ID
G54D0HMY25	UNII
57954	RXNORM
005681	NDDF
698873005	SNOMEDCT_US

Pharmaceutical products:

None