bacitracin indications/contra

Stem definitionDrug idCAS RN
281 1405-87-4

Description:

MoleculeDescription

Synonyms:

  • bacitracin
  • baciguent
  • bacillichin
  • bacilliquin
  • bacitracin zinc
A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140)
  • Molecular weight: 5648.77
  • Formula: C261H406N68O64S4
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 530.87
  • ALOGS:
  • ROTB: None

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
July 29, 1948 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1054.24 46.16 212 244 35468 3349935
Toxic anterior segment syndrome 154.09 46.16 23 433 510 3384893
Rash 128.48 46.16 49 407 70772 3314631
Anaphylactic reaction 85.32 46.16 24 432 13030 3372373
Dermatitis contact 52.85 46.16 11 445 1667 3383736

Pharmacologic Action:

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SourceCodeDescription
ATC D06AX05 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Other antibiotics for topical use
ATC J01XX10 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Other antibacterials
ATC R02AB04 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antibiotics
FDA PE N0000008479 Decreased Cell Wall Synthesis & Repair
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Keratitis indication 5888003 DOID:4677
Blepharoconjunctivitis indication 68659002 DOID:2456
Corneal abrasion indication 85848002
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Superficial Ocular Infection indication
Minor Bacterial Skin Infections indication
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Bacterial septicemia contraindication 10001005
Shock contraindication 27942005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Tuberculosis of eye contraindication 49107007
Diabetes mellitus contraindication 73211009 DOID:9351
Third degree burn injury contraindication 80247002
Decreased respiratory function contraindication 80954004
Oliguria contraindication 83128009
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Kidney disease contraindication 90708001 DOID:2527
Myasthenia gravis contraindication 91637004 DOID:437
Open wound contraindication 125643001
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002 DOID:1826
Bacterial infection of eye contraindication 128984004
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Telangiectasia disorder contraindication 247479008 DOID:1272
Injury of eye region contraindication 282752000
Pregnancy, function contraindication 289908002
Viral eye infection contraindication 312132001
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Vaccinia keratitis contraindication 397552005
Atrophoderma contraindication 399979006 DOID:2733
Peripheral vascular disease contraindication 400047006
Denuded skin contraindication 418242004
Dacryocystitis off-label use 85777005 DOID:9938
Corneal ulcer off-label use 91514001 DOID:8463
Bacterial conjunctivitis off-label use 128350005 DOID:9700
Meibomianitis off-label use 309779001

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Epidermal growth factor receptor Kinase IC50 5.27 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 5.72 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 5.87 DRUG MATRIX

External reference:

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IDSource
4017493 VUID
N0000145879 NUI
C0004599 UMLSCUI
D00128 KEGG_DRUG
58H6RWO52I UNII
1167 INN_ID
DB00626 DRUGBANK_ID
4017493 VANDF
N0000145879 NDFRT
N0000006608 NDFRT
002798 NDDF
4917 MMSL
1291 RXNORM
5220000 SNOMEDCT_US
4241 MMSL
d01115 MMSL
370330005 SNOMEDCT_US
1405-89-6 SECONDARY_CAS_RN
CHEMBL1200558 ChEMBL_ID
CHEMBL2096639 ChEMBL_ID
10909430 PUBCHEM_CID
D001414 MESH_DESCRIPTOR_UI
CHEBI:28669 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Bacitracin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0233 INJECTION, POWDER, FOR SOLUTION 5000 [USP'U] INTRAMUSCULAR ANDA 11 sections
Bacitracin HUMAN PRESCRIPTION DRUG LABEL 1 0009-0234 INJECTION, POWDER, FOR SOLUTION 5000 [USP'U] INTRAMUSCULAR ANDA 11 sections
Good Sense HUMAN OTC DRUG LABEL 3 0113-0067 OINTMENT 400 [USP'U] TOPICAL OTC monograph final 9 sections
Good Sense First Aid Antibiotic HUMAN OTC DRUG LABEL 3 0113-0084 OINTMENT 400 [USP'U] TOPICAL OTC monograph final 9 sections
Good Sense Triple Antibiotic HUMAN OTC DRUG LABEL 4 0113-0679 OINTMENT 500 [USP'U] TOPICAL OTC monograph final 9 sections
basic care first aid antibiotic HUMAN OTC DRUG LABEL 3 0113-0701 OINTMENT 400 [USP'U] TOPICAL OTC monograph final 9 sections
Bacitracin Zinc HUMAN OTC DRUG LABEL 1 0168-0011 OINTMENT 500 [USP'U] TOPICAL OTC monograph final 9 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0168-0012 OINTMENT 400 [USP'U] TOPICAL OTC monograph final 6 sections
Double Antibiotic HUMAN OTC DRUG LABEL 2 0168-0021 OINTMENT 500 [USP'U] TOPICAL OTC monograph final 5 sections
Bacitracin Zinc HUMAN OTC DRUG LABEL 1 0168-0111 OINTMENT 500 [USP'U] TOPICAL OTC monograph final 9 sections
Bacitracin Zinc and Polymyxin B Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0168-0273 OINTMENT 500 1 OPHTHALMIC ANDA 11 sections
KAISER PERMANENTE HUMAN OTC DRUG LABEL 1 0179-8012 OINTMENT 500 [iU] TOPICAL OTC MONOGRAPH FINAL 10 sections
Kaiser Permanente HUMAN OTC DRUG LABEL 2 0179-8707 OINTMENT 500 [USP'U] TOPICAL OTC MONOGRAPH FINAL 9 sections
Bacitracin HUMAN OTC DRUG LABEL 1 0295-1223 OINTMENT 500 [USP'U] TOPICAL OTC MONOGRAPH FINAL 7 sections
Antibiotic HUMAN OTC DRUG LABEL 3 0363-0018 OINTMENT 500 [iU] TOPICAL OTC MONOGRAPH FINAL 9 sections
Bacitracin HUMAN OTC DRUG LABEL 1 0363-0075 OINTMENT 500 [USP'U] TOPICAL OTC monograph final 9 sections
Triple Antibiotic with Pain Relief HUMAN OTC DRUG LABEL 4 0363-0123 OINTMENT 500 [USP'U] TOPICAL OTC MONOGRAPH FINAL 9 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-0179 OINTMENT 400 [iU] TOPICAL OTC MONOGRAPH FINAL 9 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0363-0539 OINTMENT 400 [USP'U] TOPICAL OTC monograph final 9 sections
Triple Antibiotic with Pain Relief HUMAN OTC DRUG LABEL 4 0363-0823 OINTMENT 500 [USP'U] TOPICAL OTC MONOGRAPH FINAL 10 sections
First Aid Antibiotic HUMAN OTC DRUG LABEL 4 0363-0841 OINTMENT 500 [USP'U] TOPICAL OTC monograph final 13 sections
Bacitracin Zinc HUMAN OTC DRUG LABEL 1 0363-1105 OINTMENT 500 [USP'U] TOPICAL OTC MONOGRAPH FINAL 14 sections
Walgreens HUMAN OTC DRUG LABEL 3 0363-2016 OINTMENT 400 [iU] TOPICAL OTC MONOGRAPH FINAL 9 sections
Walgreens HUMAN OTC DRUG LABEL 1 0363-2075 OINTMENT 500 [USP'U] TOPICAL OTC MONOGRAPH FINAL 10 sections
Wal-Sporin HUMAN OTC DRUG LABEL 2 0363-3000 OINTMENT 500 [USP'U] TOPICAL OTC MONOGRAPH FINAL 10 sections
Walgreens Maximum Strength Triple Antibiotic With Pain Relief HUMAN OTC DRUG LABEL 4 0363-7872 OINTMENT 500 [USP'U] TOPICAL OTC monograph final 11 sections
Walgreens Wal-Sporin First Aid Antibiotic HUMAN OTC DRUG LABEL 2 0363-8821 OINTMENT 500 [USP'U] TOPICAL OTC monograph final 11 sections
Schein Triple Antibiotic HUMAN OTC DRUG LABEL 3 0404-0360 OINTMENT 400 [iU] TOPICAL OTC monograph final 7 sections
Schein Bacitracin HUMAN OTC DRUG LABEL 1 0404-0400 OINTMENT 500 [iU] TOPICAL OTC monograph final 7 sections
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc HUMAN PRESCRIPTION DRUG LABEL 3 0404-7194 OINTMENT 400 [USP'U] OPHTHALMIC ANDA 11 sections