vancomycin Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 2807 1404-90-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vancomycin
  • diatracin
  • vancocin
  • vancocine
  • vancoled
  • vancomycin hydrochloride
  • vancomycin HCl
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
  • Molecular weight: 1449.27
  • Formula: C66H75Cl2N9O24
  • CLOGP: -1.14
  • LIPINSKI: 3
  • HAC: 33
  • HDO: 19
  • TPSA: 530.49
  • ALOGS: -3.81
  • ROTB: 13

Drug dosage:

DoseUnitRoute
2 g O
2 g P

Approvals:

DateAgencyCompanyOrphan
Nov. 6, 1964 FDA

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 5206.53 45.26 1720 12287 68711 4556274
Drug reaction with eosinophilia and systemic symptoms 4424.46 45.26 1035 12972 10678 4614307
Drug hypersensitivity 2761.76 45.26 1074 12933 67326 4557659
Red man syndrome 2283.46 45.26 362 13645 159 4624826
Linear IgA disease 2186.45 45.26 369 13638 410 4624575
Rash 1935.92 45.26 960 13047 107428 4517557
Pyrexia 1750.24 45.26 894 13113 106250 4518735
Nephropathy toxic 1596.90 45.26 374 13633 3778 4621207
Drug ineffective 1595.81 45.26 1018 12989 185043 4439942
Renal tubular necrosis 1466.74 45.26 347 13660 3671 4621314
Tubulointerstitial nephritis 1103.61 45.26 301 13706 5818 4619167
Pruritus 1082.99 45.26 572 13435 72000 4552985
Toxic epidermal necrolysis 1081.48 45.26 297 13710 5895 4619090
Blood creatinine increased 1054.04 45.26 416 13591 26484 4598501
Thrombocytopenia 1031.25 45.26 484 13523 47189 4577796
Eosinophilia 1023.16 45.26 292 13715 6701 4618284
Septic shock 973.09 45.26 346 13661 16420 4608565
Retinal vasculitis 945.76 45.26 157 13850 141 4624844
Multiple organ dysfunction syndrome 902.11 45.26 337 13670 18419 4606566
Renal impairment 875.04 45.26 358 13649 24980 4600005
Renal failure 838.64 45.26 402 13605 40967 4584018
Rash maculo-papular 838.38 45.26 262 13745 8267 4616718
Drug level increased 801.67 45.26 236 13771 6050 4618935
Erythema 791.11 45.26 388 13619 41552 4583433
Clostridium difficile infection 741.54 45.26 213 13794 4991 4619994
Acute generalised exanthematous pustulosis 726.93 45.26 187 13820 2843 4622142
Sepsis 718.37 45.26 366 13641 42473 4582512
Drug resistance 708.70 45.26 228 13779 7908 4617077
Hypotension 687.92 45.26 415 13592 66985 4558000
Staphylococcal infection 663.03 45.26 232 13775 10456 4614529
Rash erythematous 643.78 45.26 226 13781 10283 4614702
Pathogen resistance 584.77 45.26 155 13852 2661 4622324
Stevens-Johnson syndrome 537.46 45.26 188 13819 8451 4616534
Neutropenia 534.80 45.26 313 13694 47637 4577348
Leukopenia 528.69 45.26 240 13767 21496 4603489
Anaphylactic reaction 516.84 45.26 223 13784 17687 4607298
Condition aggravated 442.61 45.26 298 13709 57873 4567112
Toxic skin eruption 440.23 45.26 137 13870 4243 4620742
Urticaria 432.17 45.26 255 13752 39318 4585667
Drug eruption 419.46 45.26 146 13861 6457 4618528
Pancytopenia 408.93 45.26 210 13797 24643 4600342
Respiratory failure 405.18 45.26 223 13784 30103 4594882
Enterococcal infection 387.45 45.26 102 13905 1700 4623285
Antibiotic level above therapeutic 379.75 45.26 62 13945 44 4624941
Clostridium difficile colitis 378.55 45.26 120 13887 3950 4621035
Treatment failure 365.31 45.26 163 13844 13984 4611001
Retinal vascular occlusion 319.87 45.26 59 13948 145 4624840
Dyspnoea 316.41 45.26 357 13650 138628 4486357
Haemophagocytic lymphohistiocytosis 313.98 45.26 98 13909 3061 4621924
Systemic candida 308.91 45.26 73 13934 760 4624225
Agranulocytosis 306.54 45.26 120 13887 7397 4617588
Tachycardia 304.31 45.26 187 13820 30958 4594027
Rash morbilliform 302.99 45.26 75 13932 963 4624022
Hypersensitivity 299.38 45.26 200 13807 38221 4586764
Dermatitis exfoliative 297.09 45.26 93 13914 2933 4622052
Haemodialysis 287.13 45.26 102 13905 4785 4620200
Infusion related reaction 286.71 45.26 150 13857 18252 4606733
Leukocytosis 283.81 45.26 114 13893 7520 4617465
Skin exfoliation 273.18 45.26 123 13884 10764 4614221
Blister 266.64 45.26 123 13884 11386 4613599
Rash pruritic 251.03 45.26 121 13886 12362 4612623
Candida infection 249.99 45.26 94 13913 5187 4619798
Pseudomembranous colitis 246.11 45.26 65 13942 1096 4623889
Diarrhoea 243.05 45.26 325 13682 149860 4475125
Hepatic function abnormal 240.14 45.26 123 13884 14313 4610672
Anaemia 232.91 45.26 223 13784 71337 4553648
Chills 231.46 45.26 153 13854 28686 4596299
Pneumonia 229.90 45.26 262 13745 102553 4522432
Bacteraemia 227.75 45.26 82 13925 3998 4620987
Haemodynamic instability 226.96 45.26 74 13933 2665 4622320
Oliguria 226.22 45.26 74 13933 2693 4622292
Disseminated intravascular coagulation 221.67 45.26 95 13912 7378 4617607
Dialysis 220.31 45.26 84 13923 4815 4620170
Drug interaction 219.36 45.26 206 13801 64302 4560683
Toxicity to various agents 211.09 45.26 212 13795 71828 4553157
Blood urea increased 210.43 45.26 96 13911 8654 4616331
Respiratory distress 209.21 45.26 103 13904 11013 4613972
Device related infection 206.99 45.26 85 13922 5930 4619055
C-reactive protein increased 203.95 45.26 106 13901 12706 4612279
Face oedema 201.57 45.26 86 13921 6604 4618381
Metabolic acidosis 198.24 45.26 103 13904 12337 4612648
Cholestasis 193.94 45.26 88 13919 7832 4617153
Haemorrhagic vasculitis 191.46 45.26 32 13975 31 4624954
Alanine aminotransferase increased 190.83 45.26 135 13872 28238 4596747
Erythema multiforme 184.82 45.26 71 13936 4152 4620833
Pleural effusion 182.64 45.26 124 13883 24274 4600711
Hypoxia 181.88 45.26 99 13908 13022 4611963
Generalised oedema 181.20 45.26 71 13936 4380 4620605
Endocarditis 179.75 45.26 57 13950 1874 4623111
Klebsiella infection 179.58 45.26 56 13951 1741 4623244
Dermatitis bullous 178.74 45.26 63 13944 2884 4622101
Transaminases increased 174.78 45.26 87 13920 9519 4615466
Megacolon 173.27 45.26 44 13963 630 4624355
Pseudomonas infection 172.52 45.26 60 13947 2639 4622346
Staphylococcal bacteraemia 171.97 45.26 52 13955 1455 4623530
Flushing 170.72 45.26 109 13898 19243 4605742
Acute respiratory distress syndrome 169.92 45.26 79 13928 7434 4617551
Rash macular 167.12 45.26 72 13935 5660 4619325
General physical health deterioration 166.44 45.26 125 13882 28653 4596332
Hepatitis 166.14 45.26 91 13916 12114 4612871
Ototoxicity 163.15 45.26 42 13965 637 4624348
Cardiac arrest 162.63 45.26 132 13875 33875 4591110
Encephalopathy 159.99 45.26 83 13924 9904 4615081
Anuria 156.26 45.26 62 13945 3953 4621032
Purpura 156.16 45.26 61 13946 3731 4621254
Febrile neutropenia 153.73 45.26 115 13892 26197 4598788
White blood cell count decreased 151.09 45.26 125 13882 32940 4592045
Hypersensitivity vasculitis 150.14 45.26 54 13953 2622 4622363
White blood cell count increased 147.21 45.26 91 13916 15176 4609809
Stenotrophomonas infection 146.15 45.26 35 13972 387 4624598
Multiple-drug resistance 144.45 45.26 38 13969 630 4624355
Petechiae 140.17 45.26 57 13950 3874 4621111
Infection 137.42 45.26 123 13884 36019 4588966
Therapeutic product cross-reactivity 137.42 45.26 38 13969 767 4624218
Shock 136.81 45.26 72 13935 8844 4616141
Glomerular filtration rate decreased 135.18 45.26 53 13954 3273 4621712
Aspartate aminotransferase increased 134.65 45.26 104 13903 24834 4600151
Lymphadenopathy 134.61 45.26 75 13932 10317 4614668
Blood alkaline phosphatase increased 132.00 45.26 79 13928 12428 4612557
Unresponsive to stimuli 131.16 45.26 73 13934 10020 4614965
Device related sepsis 129.90 45.26 37 13970 835 4624150
Drug level above therapeutic 127.83 45.26 39 13968 1125 4623860
Platelet count decreased 126.93 45.26 116 13891 34886 4590099
Type IV hypersensitivity reaction 123.92 45.26 37 13970 990 4623995
Vomiting 123.02 45.26 210 13797 119489 4505496
Hepatocellular injury 121.78 45.26 64 13943 7836 4617149
Renal injury 121.32 45.26 46 13961 2593 4622392
Clostridium test positive 121.07 45.26 33 13974 630 4624355
Serotonin syndrome 119.03 45.26 61 13946 7091 4617894
Cellulitis 117.97 45.26 82 13925 16650 4608335
Therapy non-responder 116.64 45.26 80 13927 15897 4609088
Bone marrow failure 115.41 45.26 73 13934 12665 4612320
Dysbiosis 112.01 45.26 23 13984 115 4624870
Oedema peripheral 110.91 45.26 117 13890 41855 4583130
Disease progression 109.58 45.26 115 13892 40896 4584089
Fungaemia 109.27 45.26 30 13977 589 4624396
Venoocclusive liver disease 108.89 45.26 40 13967 2063 4622922
Mental status changes 107.34 45.26 69 13938 12307 4612678
Aspergillus infection 105.48 45.26 42 13965 2701 4622284
Systemic inflammatory response syndrome 105.44 45.26 38 13969 1855 4623130
Haemorrhage 105.14 45.26 91 13916 25471 4599514
Renal tubular disorder 105.07 45.26 36 13971 1512 4623473
Graft versus host disease 104.13 45.26 44 13963 3294 4621691
Hypokalaemia 102.91 45.26 79 13928 18681 4606304
Glaucoma 101.59 45.26 44 13963 3500 4621485
Inflammation 101.52 45.26 62 13945 10109 4614876
Skin necrosis 100.81 45.26 38 13969 2107 4622878
Type III immune complex mediated reaction 99.62 45.26 23 13984 214 4624771
Blood pressure decreased 99.55 45.26 76 13931 17824 4607161
Herpes simplex oesophagitis 98.83 45.26 18 13989 40 4624945
Clostridial infection 98.63 45.26 35 13972 1633 4623352
Vasculitis 96.62 45.26 45 13962 4246 4620739
Skin lesion 96.54 45.26 54 13953 7479 4617506
Eosinophil count increased 95.79 45.26 39 13968 2657 4622328
Abscess 95.74 45.26 46 13961 4654 4620331
Hepatotoxicity 94.31 45.26 55 13952 8244 4616741
Product use in unapproved indication 94.02 45.26 85 13922 25188 4599797
Nausea 93.13 45.26 236 13771 177097 4447888
Haemorrhagic disorder 92.91 45.26 24 13983 369 4624616
Body temperature increased 92.43 45.26 49 13958 6103 4618882
Rash pustular 92.42 45.26 39 13968 2910 4622075
Confusional state 91.56 45.26 114 13893 48720 4576265
Nephritis 91.29 45.26 29 13978 958 4624027
Acinetobacter infection 91.16 45.26 24 13983 399 4624586
Retinal haemorrhage 91.11 45.26 38 13969 2753 4622232
Gamma-glutamyltransferase increased 90.87 45.26 60 13947 11194 4613791
Incorrect drug administration rate 89.32 45.26 27 13980 754 4624231
Enterococcus test positive 89.16 45.26 22 13985 278 4624707
Disease recurrence 89.04 45.26 51 13956 7390 4617595
Cardio-respiratory arrest 88.53 45.26 74 13933 19748 4605237
Immune thrombocytopenic purpura 88.51 45.26 39 13968 3233 4621752
Hepatic failure 87.00 45.26 62 13945 13087 4611898
Pulmonary interstitial emphysema syndrome 86.81 45.26 16 13991 39 4624946
Eosinophilic pneumonia 86.16 45.26 29 13978 1153 4623832
Myeloma cast nephropathy 85.69 45.26 16 13991 43 4624942
Staphylococcal sepsis 85.50 45.26 35 13972 2418 4622567
Endocarditis candida 85.19 45.26 15 13992 25 4624960
Nervous system disorder 84.86 45.26 47 13960 6384 4618601
Drug-induced liver injury 84.79 45.26 52 13955 8539 4616446
Abdominal pain 84.75 45.26 122 13885 59902 4565083
Swelling face 84.70 45.26 64 13943 14776 4610209
Liver injury 84.34 45.26 43 13964 4942 4620043
Hypoalbuminaemia 83.23 45.26 37 13970 3133 4621852
Haematuria 83.16 45.26 60 13947 12910 4612075
Toxic anterior segment syndrome 82.38 45.26 24 13983 588 4624397
Tachypnoea 82.04 45.26 42 13965 4869 4620116
Oedema 81.67 45.26 69 13938 18682 4606303
Noninfectious peritonitis 81.65 45.26 16 13991 60 4624925
Diffuse alveolar damage 81.55 45.26 23 13984 500 4624485
Bacterial infection 81.32 45.26 41 13966 4602 4620383
Fungal infection 80.61 45.26 49 13958 7920 4617065
Human herpesvirus 6 infection 80.14 45.26 26 13981 920 4624065
Endophthalmitis 79.72 45.26 32 13975 2101 4622884
Alveolar lung disease 79.67 45.26 16 13991 70 4624915
Dermatitis 79.41 45.26 40 13967 4481 4620504
Haemoglobin decreased 78.86 45.26 93 13914 37564 4587421
Liver disorder 78.11 45.26 58 13949 13040 4611945
Hepatic enzyme increased 77.93 45.26 66 13941 17925 4607060
Product contamination 77.42 45.26 22 13985 492 4624493
Premature baby 74.93 45.26 51 13956 10000 4614985
Cardiac failure 73.70 45.26 77 13930 27211 4597774
Exfoliative rash 73.16 45.26 24 13983 880 4624105
Maternal exposure during pregnancy 72.59 45.26 62 13945 17031 4607954
Meningitis 71.12 45.26 30 13977 2235 4622750
Blood culture positive 70.79 45.26 27 13980 1546 4623439
Suspected transmission of an infectious agent via product 70.72 45.26 18 13989 260 4624725
Pulse absent 70.47 45.26 29 13978 2030 4622955
Inflammatory marker increased 70.17 45.26 24 13983 1002 4623983
Osteomyelitis 70.15 45.26 41 13966 6167 4618818
Lip swelling 69.43 45.26 45 13962 8134 4616851
Cardiac valve vegetation 69.03 45.26 17 13990 213 4624772
Deafness 68.47 45.26 38 13969 5181 4619804
Trichosporon infection 67.90 45.26 16 13991 164 4624821
Urine output decreased 67.85 45.26 32 13975 3105 4621880
Wheezing 67.80 45.26 50 13957 11124 4613861
Blood lactate dehydrogenase increased 67.42 45.26 43 13964 7560 4617425
Hypoacusis 66.93 45.26 40 13967 6269 4618716
Blood bilirubin increased 66.58 45.26 52 13955 12600 4612385
Hyperkalaemia 66.35 45.26 57 13950 15780 4609205
Oxygen saturation decreased 65.71 45.26 54 13953 14067 4610918
Enterococcal bacteraemia 64.77 45.26 18 13989 370 4624615
Drug ineffective for unapproved indication 64.67 45.26 38 13969 5773 4619212
Renal disorder 63.76 45.26 45 13962 9351 4615634
Exposure during pregnancy 63.41 45.26 78 13929 32893 4592092
Bronchospasm 63.28 45.26 37 13970 5569 4619416
Swelling 62.41 45.26 67 13940 24415 4600570
Haemolytic anaemia 61.98 45.26 33 13974 4145 4620840
Product preparation error 61.76 45.26 25 13982 1677 4623308
Enterocolitis haemorrhagic 61.74 45.26 20 13987 704 4624281
Angioedema 61.08 45.26 60 13947 19705 4605280
Henoch-Schonlein purpura 60.53 45.26 20 13987 750 4624235
Kounis syndrome 60.40 45.26 20 13987 755 4624230
Bronchopulmonary aspergillosis 60.06 45.26 29 13978 2965 4622020
Staphylococcus test positive 59.68 45.26 21 13986 955 4624030
Circulatory collapse 59.21 45.26 40 13967 7745 4617240
Fungal sepsis 58.68 45.26 17 13990 408 4624577
Jaundice 58.66 45.26 48 13959 12426 4612559
Escherichia infection 58.62 45.26 27 13980 2482 4622503
Retinal ischaemia 57.98 45.26 15 13992 232 4624753
Nephropathy 57.68 45.26 25 13982 1991 4622994
Blindness 57.02 45.26 38 13969 7194 4617791
Mucormycosis 56.97 45.26 22 13985 1303 4623682
Hepatomegaly 56.96 45.26 30 13977 3685 4621300
Meningitis candida 56.67 45.26 10 13997 17 4624968
Lethargy 56.40 45.26 54 13953 17187 4607798
Septic embolus 55.92 45.26 16 13991 367 4624618
Endocarditis staphylococcal 54.76 45.26 14 13993 206 4624779
Sepsis neonatal 54.65 45.26 15 13992 294 4624691
Depressed level of consciousness 54.44 45.26 50 13957 15104 4609881
Loss of consciousness 53.97 45.26 75 13932 35607 4589378
Peritonitis 52.74 45.26 33 13974 5612 4619373
Product use issue 52.67 45.26 62 13945 24974 4600011
Poor quality product administered 52.64 45.26 22 13985 1601 4623384
Post procedural complication 52.07 45.26 33 13974 5738 4619247
Organ failure 52.01 45.26 19 13988 964 4624021
Metastases to bone marrow 51.92 45.26 13 13994 175 4624810
Drug level below therapeutic 51.25 45.26 20 13987 1218 4623767
Anaphylactoid reaction 51.08 45.26 22 13985 1725 4623260
Acidosis 50.79 45.26 27 13980 3379 4621606
Laryngeal stenosis 50.41 45.26 12 13995 129 4624856
Dysphagia 50.05 45.26 61 13946 25470 4599515
Metastases to retroperitoneum 49.57 45.26 10 13997 45 4624940
Arthritis bacterial 49.39 45.26 21 13986 1595 4623390
Malaise 49.26 45.26 122 13885 90035 4534950
Hypertension 49.23 45.26 87 13920 50711 4574274
Vestibular disorder 49.21 45.26 15 13992 431 4624554
Metastases to muscle 48.86 45.26 10 13997 49 4624936
Liver abscess 48.44 45.26 19 13988 1173 4623812
Dehydration 48.38 45.26 78 13929 42212 4582773
Central nervous system injury 48.25 45.26 8 13999 7 4624978
Umbilical erythema 48.25 45.26 8 13999 7 4624978
Restlessness 47.83 45.26 38 13969 9431 4615554
Leuconostoc infection 47.73 45.26 8 13999 8 4624977
Bradycardia 47.65 45.26 56 13951 22513 4602472
Factor V inhibition 47.48 45.26 11 13996 104 4624881
Anaphylactic shock 47.30 45.26 35 13972 7822 4617163
Deafness neurosensory 47.07 45.26 19 13988 1265 4623720
Hyperammonaemia 46.91 45.26 22 13985 2107 4622878
Haematochezia 46.70 45.26 40 13967 11024 4613961
Eczema 46.41 45.26 31 13976 5890 4619095
Status epilepticus 46.33 45.26 29 13978 4934 4620051
Respiratory acidosis 46.04 45.26 20 13987 1601 4623384
Arthritis infective 45.83 45.26 18 13989 1115 4623870
Rash papular 45.72 45.26 28 13979 4583 4620402
Fluid overload 45.67 45.26 29 13978 5059 4619926
Papule 45.60 45.26 20 13987 1639 4623346
Haemolysis 45.52 45.26 23 13984 2592 4622393

Pharmacologic Action:

SourceCodeDescription
ATC A07AA09 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC J01XA01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Glycopeptide antibacterials
ATC S01AA28 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
FDA EPC N0000175491 Glycopeptide Antibacterial
FDA Chemical/Ingredient N0000007889 Glycopeptides
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bacterial septicemia indication 10001005 DOID:0040085
Staphylococcal pneumonia indication 22754005
Staphylococcal enterocolitis indication 32527003
Staphylococcal infectious disease indication 56038003
Staphylococcal endocarditis indication 73028002
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Sepsis of the newborn indication 206376005
Neonatal pneumonia indication 233619008
Bacterial endocarditis indication 301183007
Infectious disorder of joint indication 363162000
Pseudomembranous enterocolitis indication 397683000
Infection due to Staphylococcus aureus indication 406602003
Osteomyelitis due to Staphylococcus aureus indication 428783003
Prosthetic Heart Valve Endocarditis indication
Diphtheroid Prosthetic Heart Valve Endocarditis indication
Streptococcal Endocarditis indication
Staphylococcus Epidermidis Skin and Skin Structure Infection indication
Staphylococcal Prosthetic Heart Valve Endocarditis indication
Neonatal Group B Streptococcal Septicemia indication
Streptococcal meningitis off-label use 4510004 DOID:11574
Pyrexia of unknown origin off-label use 7520000
Inhalational anthrax off-label use 11389007
Staphylococcal meningitis off-label use 12166008
Diphtheritic myocarditis off-label use 26117009
Erysipelas off-label use 44653001 DOID:11330
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Neonatal meningitis off-label use 276674008
Anthrax off-label use 409498004 DOID:7427
Abscess of brain off-label use 441806004
Listeria Monocytogenes Septicemia off-label use
Diabetic Foot Infection Due to Gram-Positive Bacteria off-label use
Perioperative Infection off-label use
Prevention of Perioperative Infection off-label use
Acute nephropathy contraindication 58574008
Kidney disease contraindication 90708001 DOID:557
Hearing disorder contraindication 128540005
Vancomycin poisoning contraindication 291518001
Neutropenic disorder contraindication 303011007 DOID:1227

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.55 acidic
pKa2 7.69 acidic
pKa3 10.72 acidic
pKa4 11.48 acidic
pKa5 11.49 acidic
pKa6 12.17 acidic
pKa7 12.41 acidic
pKa8 12.78 acidic
pKa9 13.04 acidic
pKa10 13.2 acidic
pKa11 13.59 acidic
pKa12 8.96 Basic
pKa13 8.3 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 1.5GM BASE/300ML VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.5GM BASE/300ML VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1GM BASE/200ML VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1GM BASE/200ML VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 2GM BASE/400ML VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 2GM BASE/400ML VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 500MG BASE/100ML VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 500MG BASE/100ML VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2A adrenergic receptor GPCR Ki 7.30 CHEMBL
D-alanyl-D-alanine dipeptidase Unclassified Ki 4.21 CHEMBL
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Unclassified IC50 5 CHEMBL

External reference:

IDSource
4019967 VUID
N0000148052 NUI
C0042313 UMLSCUI
D00212 KEGG_DRUG
6Q205EH1VU UNII
680 INN_ID
1404-93-9 SECONDARY_CAS_RN
42082003 SNOMEDCT_US
253520 MMSL
4019967 VANDF
11124 RXNORM
372735009 SNOMEDCT_US
d00125 MMSL
004866 NDDF
CHEMBL262777 ChEMBL_ID
DB00512 DRUGBANK_ID
CHEMBL1200628 ChEMBL_ID
CHEBI:76842 CHEBI
D014640 MESH_DESCRIPTOR_UI
14969 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0867 CAPSULE 125 mg ORAL ANDA 16 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0890 CAPSULE 250 mg ORAL ANDA 16 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9355 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 750 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9358 INJECTION, POWDER, FOR SOLUTION 5 g INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9359 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3551 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3552 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3580 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3581 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3582 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3583 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-4332 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6509 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6510 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6531 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 750 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6533 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6534 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 15 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6535 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 15 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-3187 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-3188 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-741 CAPSULE 125 mg ORAL ANDA 17 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-742 CAPSULE 250 mg ORAL ANDA 17 sections
Sterile Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-424 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 13 sections
Vancomycin HUMAN PRESCRIPTION DRUG LABEL 1 25021-157 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 g INTRAVENOUS ANDA 13 sections
Vancomycin HUMAN PRESCRIPTION DRUG LABEL 1 25021-158 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 g INTRAVENOUS ANDA 13 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 45932-0028 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 13 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 45932-0029 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 13 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 45932-0031 INJECTION 5 g INTRAVENOUS ANDA 13 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 45932-0032 INJECTION 10 g INTRAVENOUS ANDA 13 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 47781-597 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 14 sections