vancomycin indications/contra

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 2807 1404-90-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vancomycin
  • diatracin
  • vancocin
  • vancocine
  • vancoled
  • vancomycin hydrochloride
  • vancomycin HCl
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
  • Molecular weight: 1449.27
  • Formula: C66H75Cl2N9O24
  • CLOGP: -1.14
  • LIPINSKI: 3
  • HAC: 33
  • HDO: 19
  • TPSA: 530.49
  • ALOGS: -3.81
  • ROTB: 13

Drug dosage:

DoseUnitRoute
2 g O
2 g P

Approvals:

DateAgencyCompanyOrphan
Nov. 6, 1964 FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 3307.25 43.65 1069 7756 48614 3328420
Drug reaction with eosinophilia and systemic symptoms 2579.01 43.65 598 8227 7297 3369737
Red man syndrome 1645.74 43.65 253 8572 111 3376923
Drug hypersensitivity 1486.49 43.65 545 8280 35135 3341899
Pyrexia 1285.20 43.65 622 8203 80493 3296541
Nephropathy toxic 1279.92 43.65 285 8540 2804 3374230
Rash 1187.02 43.65 565 8260 70256 3306778
Linear IgA disease 1177.75 43.65 193 8632 221 3376813
Renal tubular necrosis 1114.96 43.65 255 8570 2853 3374181
Blood creatinine increased 915.21 43.65 336 8489 21482 3355552
Pruritus 878.61 43.65 405 8420 46428 3330606
Toxic epidermal necrolysis 807.44 43.65 212 8613 4333 3372701
Tubulointerstitial nephritis 790.75 43.65 207 8618 4179 3372855
Retinal vasculitis 752.50 43.65 121 8704 109 3376925
Eosinophilia 750.31 43.65 203 8622 4670 3372364
Thrombocytopenia 739.51 43.65 330 8495 34938 3342096
Drug ineffective 677.78 43.65 466 8359 115624 3261410
Renal failure 670.41 43.65 302 8523 32638 3344396
Septic shock 659.21 43.65 227 8598 11957 3365077
Multiple organ dysfunction syndrome 644.42 43.65 233 8592 14177 3362857
Renal impairment 640.37 43.65 247 8578 18014 3359020
Hypotension 627.13 43.65 328 8497 49186 3327848
Rash maculo-papular 562.66 43.65 169 8656 5698 3371336
Drug level increased 537.29 43.65 154 8671 4391 3372643
Acute generalised exanthematous pustulosis 526.04 43.65 129 8696 1970 3375064
Rash erythematous 523.94 43.65 172 8653 7790 3369244
Erythema 522.38 43.65 244 8581 28566 3348468
Sepsis 474.44 43.65 237 8588 32136 3344898
Stevens-Johnson syndrome 452.32 43.65 148 8677 6624 3370410
Staphylococcal infection 418.01 43.65 148 8677 8431 3368603

Pharmacologic Action:

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SourceCodeDescription
ATC A07AA09 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC J01XA01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Glycopeptide antibacterials
FDA EPC N0000175491 Glycopeptide Antibacterial
FDA Chemical/Ingredient N0000007889 Glycopeptides
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Bacterial septicemia indication 10001005
Staphylococcal pneumonia indication 22754005
Staphylococcal enterocolitis indication 32527003
Staphylococcal infectious disease indication 56038003
Staphylococcal endocarditis indication 73028002
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Sepsis of the newborn indication 206376005
Neonatal pneumonia indication 233619008
Bacterial endocarditis indication 301183007
Infectious disorder of joint indication 363162000 DOID:381
Pseudomembranous enterocolitis indication 397683000 DOID:0060185
Infection due to Staphylococcus aureus indication 406602003
Osteomyelitis due to Staphylococcus aureus indication 428783003
Prosthetic Heart Valve Endocarditis indication
Staphylococcus Epidermidis Skin and Skin Structure Infection indication
Streptococcal Endocarditis indication
Neonatal Group B Streptococcal Septicemia indication
Staphylococcal Prosthetic Heart Valve Endocarditis indication
Diphtheroid Prosthetic Heart Valve Endocarditis indication
Acute nephropathy contraindication 58574008
Kidney disease contraindication 90708001 DOID:2527
Hearing disorder contraindication 128540005
Vancomycin poisoning contraindication 291518001
Neutropenic disorder contraindication 303011007 DOID:1227
Streptococcal meningitis off-label use 4510004 DOID:11574
Pyrexia of unknown origin off-label use 7520000
Inhalational anthrax off-label use 11389007
Staphylococcal meningitis off-label use 12166008
Diphtheritic myocarditis off-label use 26117009
Erysipelas off-label use 44653001 DOID:11330
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Neonatal meningitis off-label use 276674008
Anthrax off-label use 409498004 DOID:7427
Abscess of brain off-label use 441806004
Prevention of Perioperative Infection off-label use
Listeria Monocytogenes Septicemia off-label use
Diabetic Foot Infection Due to Gram-Positive Bacteria off-label use
Perioperative Infection off-label use

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2A adrenergic receptor GPCR Ki 7.30 CHEMBL
D-alanyl-D-alanine dipeptidase Unclassified Ki 4.21 CHEMBL
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Unclassified IC50 5 CHEMBL

External reference:

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IDSource
DB00512 DRUGBANK_ID
4019967 VUID
N0000148052 NUI
C0042313 UMLSCUI
D00212 KEGG_DRUG
6Q205EH1VU UNII
680 INN_ID
1404-93-9 SECONDARY_CAS_RN
CHEMBL262777 ChEMBL_ID
4019967 VANDF
N0000148052 NDFRT
N0000006271 NDFRT
11124 RXNORM
372735009 SNOMEDCT_US
42082003 SNOMEDCT_US
d00125 MMSL
004866 NDDF
CHEMBL1200628 ChEMBL_ID
14969 PUBCHEM_CID
D014640 MESH_DESCRIPTOR_UI
CHEBI:76842 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-2587 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-2589 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 14 sections
STERILE VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0069-2590 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 g INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-2599 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 g INTRAVENOUS ANDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0069-2601 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 g INTRAVENOUS ANDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3551 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3552 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3580 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3581 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3582 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3583 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-4332 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6509 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6510 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6531 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 750 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6533 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6534 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 15 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-6535 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 15 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-3187 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-3188 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 14 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-741 CAPSULE 125 mg ORAL ANDA 17 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-742 CAPSULE 250 mg ORAL ANDA 17 sections
Sterile Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-424 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 13 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 23155-218 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 14 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 23155-219 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 g INTRAVENOUS ANDA 14 sections
VANCOMYCIN HYDROCLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 23155-220 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 g INTRAVENOUS ANDA 14 sections
Vancomycin HUMAN PRESCRIPTION DRUG LABEL 1 25021-157 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 5 g INTRAVENOUS ANDA 13 sections
Vancomycin HUMAN PRESCRIPTION DRUG LABEL 1 25021-158 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 g INTRAVENOUS ANDA 13 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 45932-0028 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 13 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 45932-0029 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 13 sections