valethamate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2800	16376-74-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

valethamate bromide
valethamate

Molecular weight: 306.47
Formula: C19H32NO2
CLOGP: 0.98
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 26.30
ALOGS: -6.72
ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A03AX14	ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Other drugs for functional gastrointestinal disorders

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	6.70		CHEMBL
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	8.56		CHEMBL
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	7.72		CHEMBL
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	8.25		CHEMBL
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	8.44		CHEMBL
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	7.62		CHEMBL
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6.60		CHEMBL

External reference:

ID	Source
D01538	KEGG_DRUG
90-22-2	SECONDARY_CAS_RN
C0077981	UMLSCUI
CHEBI:32288	CHEBI
CHEMBL2111176	ChEMBL_ID
CHEMBL2107687	ChEMBL_ID
DB13497	DRUGBANK_ID
C004904	MESH_SUPPLEMENTAL_RECORD_UI
5648	PUBCHEM_CID
D64S64QVX7	UNII
001745	NDDF
1172831004	SNOMEDCT_US
4814001	SNOMEDCT_US
708134005	SNOMEDCT_US

Pharmaceutical products:

None